所有图片(1)
About This Item
经验公式（希尔记法）:
C19H35N3O4S
CAS号:
分子量:
401.56
Beilstein:
7693643
MDL编号:
UNSPSC代码:
12352200
PubChem化学物质编号:
NACRES:
NA.77
推荐产品
方案
≥95% (HPLC)
质量水平
表单
powder
颜色
white
溶解性
ethanol: 20 mg/mL
储存温度
−20°C
SMILES字符串
[H]C(=O)[C@H](CCSC)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(C)=O
InChI
1S/C19H35N3O4S/c1-12(2)9-16(20-14(5)24)19(26)22-17(10-13(3)4)18(25)21-15(11-23)7-8-27-6/h11-13,15-17H,7-10H2,1-6H3,(H,20,24)(H,21,25)(H,22,26)/t15-,16-,17-/m0/s1
InChI key
RJWLAIMXRBDUMH-ULQDDVLXSA-N
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应用
钙蛋白酶抑制剂 II 已用于蛋白质印迹。此外，它还用于研究Spy1A（一类细胞周期蛋白）在细胞周期中的降解机制。
钙蛋白酶抑制剂II是一种细胞透过性肽，可限制钙蛋白酶、组织蛋白酶 L 和组织蛋白酶 B 的活性。钙蛋白酶抑制剂 II 还可以防止甲基汞诱导的大鼠小脑神经元细胞死亡。
生化/生理作用
钙蛋白酶是在神经系统中表达的半胱氨酸蛋白酶。钙蛋白酶表现出钙依赖性酶活性。在小鼠模型中，抑制钙蛋白酶可防止血管紧张素II诱导的白细胞浸润，并减轻血管周围炎症。
其他说明
以前为 CAS# 136632-32-1
储存分类代码
11 - Combustible Solids
WGK
WGK 1
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, type N95 (US)
历史批次信息供参考:
分析证书(COA)
Lot/Batch Number
Zachary A Gurard-Levin et al.
Antiviral research, 182, 104924-104924 (2020-09-09)
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the cause of the COVID-19 pandemic that began in 2019. The coronavirus 3-chymotrypsin-like cysteine protease (3CLpro) controls replication and is therefore considered a major target for antiviral discovery. This study describes the
J Sebastián Yakisich et al.
Investigational new drugs, 28(3), 242-250 (2009-03-17)
By using mini-units of tissue and protease inhibitors in short term incubation (0-180 min), we studied the role of proteolysis for ongoing DNA replication in the developing rat cerebral cortex. The protease inhibitors TLCK, TPCK, PMSF, MG-132 and PSI markedly
Motoharu Sakaue et al.
Toxicology, 213(1-2), 97-106 (2005-06-29)
Methylmercury, an environmental neurotoxicant, induces the apoptotic death of cerebellar granule cells in vitro at a low concentration. To further understand the mechanism of cell death, we used a rat cerebellar granule cell culture system to investigate whether the calpain/cyclin-dependent
M W Luong et al.
Toxicology and industrial health, 25(3), 169-176 (2009-06-02)
The objective of this study was to examine the potential of arsenate to induce cardiomyocyte cell death and to explore the cellular mechanisms of arsenate toxicity. Isolated cardiomyocytes in culture from embryonic chick hearts were treated with a pentavalent arsenic
Aneurysm: New Insights for the Healthcare Professional, 56-57 (2013)
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