推荐产品
生物来源
synthetic
质量水平
检测方案
≥99%
形式
powder
pKa
7.2
mp
258-259 °C
溶解性
1 M NH4OH: 50 mg/mL
DMSO: soluble
methanol and ethanol: slightly soluble
SMILES字符串
CC(=O)Nc1nnc(s1)S(N)(=O)=O
InChI
1S/C4H6N4O3S2/c1-2(9)6-3-7-8-4(12-3)13(5,10)11/h1H3,(H2,5,10,11)(H,6,7,9)
InChI key
BZKPWHYZMXOIDC-UHFFFAOYSA-N
基因信息
human ... CA1(759) , CA12(771) , CA14(23632) , CA2(760) , CA3(761) , CA4(762) , CA5A(763) , CA5B(11238) , CA9(768)
mouse ... Car13(71934) , Car5a(12352)
rat ... Car2(54231) , Car4(29242)
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应用
乙酰唑胺已被用于：
- 研究其对脂肪变性肝移植物抗冷缺血再灌注损伤的保护作用{49）
- 通过盒式给药和快速平衡透析插入物，对其结合分离的猪视网膜色素上皮（RPE）黑色素的能力进行测定
- 验证用于发育毒性筛选测定的P19C5干细胞的体外成胃模型
- 通过酶动力学、体外、体内和计算机分析，研究在斑马鱼和A375人黑素瘤细胞中其对黑素生成的抑制作用
碳酸酐酶抑制剂；增加脑血流量。
生化/生理作用
乙酰唑胺是磺酰胺药物家族的成员之一。它具有抑制碳酸酐酶活性的能力。它能够迅速增加脑血流量（CBF），并作为一种研究工具用于CBF研究中。乙酰唑胺可作为癫痫、 青光眼和假瘤脑的治疗剂。
通过与水通道蛋白相互作用抑制膜的水渗透性
警示用语：
Warning
危险声明
危险分类
Eye Irrit. 2 - Skin Irrit. 2
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
dust mask type N95 (US), Eyeshields, Gloves
法规信息
监管及禁止进口产品
Effect of acetazolamide on cerebral blood flow and cerebral metabolic rate for oxygen.
Vorstrup S, et al.
The Journal of Clinical Investigation, 74(5), 1634-1639 (1984)
Acetazolamide inhibits the level of tyrosinase and melanin: an enzyme kinetic, in vitro, in vivo, and in silico studies
Abbas Q, et al.
Chemistry and Biodiversity, 14(9), e1700117-e1700117 (2017)
Lorenzo Biancalana et al.
Dalton transactions (Cambridge, England : 2003), 47(28), 9367-9384 (2018-06-29)
The carbonic anhydrase inhibitor acetazolamide (AcmH2) reacted with [(η6-p-cymene)RuCl(μ-Cl)]2 to afford [(η6-p-cymene)RuCl2(κN-AcmH2)], 1A, in near-quantitative yield. In methanol, 1A exists in equilibrium with 1B, being probably a coordination isomer, as established by VT 1H-EXSY NMR spectroscopy. DFT calculations pointed to
Maria Skytte Torring et al.
Investigative ophthalmology & visual science, 50(1), 345-351 (2008-09-02)
Carbonic anhydrase inhibitors reduce intraocular pressure, which may protect the optic nerve from ischemia. However, carbonic anhydrase inhibitors have also been shown to dilate the blood vessels in the retina and the optic nerve head. The purpose of the present
Gianfranco Bazzu et al.
Analytical chemistry, 81(6), 2235-2241 (2009-02-19)
A miniaturized biotelemetric device for the amperometric detection of brain tissue oxygen is presented. The new system, derived from a previous design, has been coupled with a carbon microsensor for the real-time detection of dissolved O(2) in the striatum of
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