推荐产品
生物来源
rabbit
质量水平
偶联物
unconjugated
抗体形式
affinity isolated antibody
抗体产品类型
primary antibodies
克隆
polyclonal
表单
lyophilized powder
种属反应性
human, mouse, rat
技术
flow cytometry: suitable (indirect)
immunocytochemistry: suitable
immunohistochemistry: suitable
western blot: suitable
UniProt登记号
储存温度
−20°C
靶向翻译后修饰
unmodified
基因信息
human ... AQP4(361)
mouse ... Aqp4(11829)
rat ... Aqp4(25293)
一般描述
AQP4是一种调节中枢神经系统水流量的渗透压感受器。它在星形胶质细胞中含量丰富，而在肺、肠、眼和肾组织中含量较少。兔抗水通道蛋白4抗体可识别人、小鼠和大鼠中的水通道蛋白4。
免疫原
对应于与GST融合的大鼠AQP4的残基249-323的重组融合蛋白。
应用
兔抗水通道蛋白4抗体可用于免疫组化。该抗体还可用于免疫细胞化学、蛋白质印迹和流式细胞术应用。
生化/生理作用
使用2μl/mll的兔抗AQP4作为一抗，对使用GFP-AQP4转染的HEK-293细胞进行免疫沉淀和蛋白质印迹分析。
外形
从含有1%牛血清白蛋白和0.05%叠氮化钠的磷酸盐缓冲盐水（pH 7.4）中冻干。
免责声明
除非我们的产品目录或产品附带的其他公司文档另有说明，否则我们的产品仅供研究使用，不得用于任何其他目的，包括但不限于未经授权的商业用途、体外诊断用途、离体或体内治疗用途或任何类型的消费或应用于人类或动物。
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储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
常规特殊物品
Paraneoplastic Neuromyelitis Optica Associated with Lung Adenocarcinoma in a Young Woman.
Kyoung Won Baik et al.
Journal of clinical neurology (Seoul, Korea), 14(2), 246-247 (2018-04-10)
Gry Fluge Vindedal et al.
Molecular and cellular neurosciences, 77, 47-52 (2016-11-05)
There is a constitutive production of water in brain. The efflux routes of this excess water remain to be identified. We used basal brain water content as a proxy for the capacity of water exit routes. Basal brain water content
Michelle Figueroa et al.
JAMA neurology, 71(4), 495-498 (2014-04-16)
Reports of neuromyelitis optica spectrum disorder (NMOSD) occurring in the setting of neoplasia suggest that aquaporin-4 autoimmunity may in some cases have a paraneoplastic basis. In this case report, we describe a patient with NMOSD whose test results were seropositive
Friederike Tuller et al.
Journal of neuroinflammation, 13(1), 176-176 (2016-07-03)
The discovery of a highly specific antibody against the aquaporin-4 (AQP4) water channel (AQP4-IgG) unified the spectrum of neuromyelitis optica spectrum disorders (NMOSD), which are considered to be antibody-mediated autoimmune diseases. The AQP4 water channel is located on astrocytic end-feet
Krysti L Todd et al.
Frontiers in aging neuroscience, 9, 445-445 (2018-01-31)
Ventriculomegaly (expansion of the brain's fluid-filled ventricles), a condition commonly found in the aging brain, results in areas of gliosis where the ependymal cells are replaced with dense astrocytic patches. Loss of ependymal cells would compromise trans-ependymal bulk flow mechanisms
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