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A5602

Sigma-Aldrich

AMD3100 八盐酸盐 水合物

≥97% (NMR), solid, CXCR4 antagonist

别名:

1,1′-[1,4-亚苯基双（亚甲基）]双-1,4,8,11-四氮杂 八盐酸盐, JM3100, SID791, 普乐沙福

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About This Item

经验公式（希尔记法）:
C28H54N8 · 8HCl · xH2O
CAS号:
155148-31-5
分子量:
794.47 (anhydrous basis)
MDL编号:
MFCD29072959
UNSPSC代码:
51111800
PubChem化学物质编号:
24724394
NACRES:
NA.77

产品名称

AMD3100 八盐酸盐 水合物, ≥97% (NMR), solid

质量水平

100

方案

≥97% (NMR)

表单

solid

储存条件

desiccated

溶解性

H2O: ≥10 mg/mL, clear

创始人

Sanofi Aventis

储存温度

−20°C

SMILES字符串

Cl[H].Cl[H].Cl[H].Cl[H].Cl[H].Cl[H].Cl[H].Cl[H].[H]O[H].C1CNCCNCCCN(CCNC1)Cc2ccc(CN3CCCNCCNCCCNCC3)cc2

InChI

1S/C28H54N8.8ClH.H2O/c1-9-29-15-17-31-13-3-21-35(23-19-33-11-1)25-27-5-7-28(8-6-27)26-36-22-4-14-32-18-16-30-10-2-12-34-20-24-36;;;;;;;;;/h5-8,29-34H,1-4,9-26H2;8*1H;1H2

InChI key

GKFHDCZYJHUPEN-UHFFFAOYSA-N

应用

AMD3100是一种高度特异性的趋化因子受体CXCR4的拮抗剂。 AMD3100已被用于一项研究，以确定其对口腔鳞状细胞癌中CXCR4的阻断和对淋巴结转移的抑制。

生化/生理作用

AMD3100是一种高度特异性的趋化因子受体CXCR4的拮抗剂。

特点和优势

该化合物是由 Sanofi Aventis开发。浏览其他医药开发的化合物和已批准的药物/候选药物清单，请点击这里。

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

Eyeshields, Gloves, type N95 (US)

从最新的版本中选择一种：

分析证书(COA)

Lot/Batch Number
0000222070
0000406714
0000368675
0000367174
0000311272

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  1. Which document(s) contains shelf-life or expiration date information for a given product?

    If available for a given product, the recommended re-test date or the expiration date can be found on the Certificate of Analysis.

  2. How do I get lot-specific information or a Certificate of Analysis?

    The lot specific COA document can be found by entering the lot number above under the "Documents" section.

  3. What is the solubility of Product A5602, AMD3100 octahydrochloride hydrate?

    AMD3100 octahydrochloride hydrate is soluble in water at 22 mg/ml.

  4. Can solutions of Product A5602, AMD3100 octahydrochloride hydrate, be stored?

    Sigma-Aldrich has not evaluated the solution stability of A5602.  If no information on the solution stability is found from a literature search, we would recommend that that you prepare solutions fresh.

  5. What biological effects has been reported for Product A5602, AMD3100 octahydrochloride hydrate?

    This is a highly specific chemokine receptor CXCR4 antagonist. CXCR4 has been implicated in inflammation, cancer, and HIV infection.

  6. How do I find price and availability?

    There are several ways to find pricing and availability for our products. Once you log onto our website, you will find the price and availability displayed on the product detail page. You can contact any of our Customer Sales and Service offices to receive a quote.  USA customers:  1-800-325-3010 or view local office numbers.

  7. What is the Department of Transportation shipping information for this product?

    Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product. 

  8. My question is not addressed here, how can I contact Technical Service for assistance?

    Ask a Scientist here.

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An autochthonous model of pancreatic ductal adenocarcinoma (PDA) permitted the analysis of why immunotherapy is ineffective in this human disease. Despite finding that PDA-bearing mice had cancer cell-specific CD8(+) T cells, the mice, like human patients with PDA, did not
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