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Merck
CN

A5602

AMD3100 八盐酸盐 水合物

≥97% (NMR), solid, CXCR4 antagonist

别名:

1,1′-[1,4-亚苯基双（亚甲基）]双-1,4,8,11-四氮杂 八盐酸盐, JM3100, SID791, 普乐沙福

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关于此项目

经验公式（希尔记法）:
C28H54N8 · 8HCl · xH2O
化学文摘社编号:
155148-31-5
分子量:
794.47 (anhydrous basis)
MDL number:
MFCD29072959
UNSPSC Code:
51111800
PubChem Substance ID:
24724394
NACRES:
NA.77

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产品名称

AMD3100 八盐酸盐 水合物, ≥97% (NMR), solid

SMILES string

Cl[H].Cl[H].Cl[H].Cl[H].Cl[H].Cl[H].Cl[H].Cl[H].[H]O[H].C1CNCCNCCCN(CCNC1)Cc2ccc(CN3CCCNCCNCCCNCC3)cc2

InChI

1S/C28H54N8.8ClH.H2O/c1-9-29-15-17-31-13-3-21-35(23-19-33-11-1)25-27-5-7-28(8-6-27)26-36-22-4-14-32-18-16-30-10-2-12-34-20-24-36;;;;;;;;;/h5-8,29-34H,1-4,9-26H2;8*1H;1H2

InChI key

GKFHDCZYJHUPEN-UHFFFAOYSA-N

assay

≥97% (NMR)

form

solid

storage condition

desiccated

solubility

H2O: ≥10 mg/mL, clear

originator

Sanofi Aventis

storage temp.

−20°C

Quality Level

100

相关类别

Application

AMD3100是一种高度特异性的趋化因子受体CXCR4的拮抗剂。 AMD3100已被用于一项研究，以确定其对口腔鳞状细胞癌中CXCR4的阻断和对淋巴结转移的抑制。

Biochem/physiol Actions

AMD3100是一种高度特异性的趋化因子受体CXCR4的拮抗剂。

Features and Benefits

该化合物是由 Sanofi Aventis开发。浏览其他医药开发的化合物和已批准的药物/候选药物清单，请点击这里。

存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
0000479917
0000479917
0000428487
0000428487
0000222070

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  1. Which document(s) contains shelf-life or expiration date information for a given product?

    If available for a given product, the recommended re-test date or the expiration date can be found on the Certificate of Analysis.

  2. How do I get lot-specific information or a Certificate of Analysis?

    The lot specific COA document can be found by entering the lot number above under the "Documents" section.

  3. What is the solubility of Product A5602, AMD3100 octahydrochloride hydrate?

    AMD3100 octahydrochloride hydrate is soluble in water at 22 mg/ml.

  4. Can solutions of Product A5602, AMD3100 octahydrochloride hydrate, be stored?

    Sigma-Aldrich has not evaluated the solution stability of A5602.  If no information on the solution stability is found from a literature search, we would recommend that that you prepare solutions fresh.

  5. What biological effects has been reported for Product A5602, AMD3100 octahydrochloride hydrate?

    This is a highly specific chemokine receptor CXCR4 antagonist. CXCR4 has been implicated in inflammation, cancer, and HIV infection.

  6. How do I find price and availability?

    There are several ways to find pricing and availability for our products. Once you log onto our website, you will find the price and availability displayed on the product detail page. You can contact any of our Customer Sales and Service offices to receive a quote.  USA customers:  1-800-325-3010 or view local office numbers.

  7. What is the Department of Transportation shipping information for this product?

    Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product. 

  8. My question is not addressed here, how can I contact Technical Service for assistance?

    Ask a Scientist here.

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The hypoxic state of the brain tissue surrounding craniocerebral injury induces an increase in the secretion of HIF‑1α during the healing process. HIF‑1α can promote mesenchymal stem cell (MSC) migration to ischemic and hypoxic sites by regulating the expression levels
Imadeldin Yahya et al.
Scientific reports, 10(1), 5049-5049 (2020-03-21)
The present study shows that the CXCR4/SDF-1 axis regulates the migration of second branchial arch-derived muscles as well as non-somitic neck muscles. Cxcr4 is expressed by skeletal muscle progenitor cells in the second branchial arch (BA2). Muscles derived from the
David H McDermott et al.
Blood, 123(15), 2308-2316 (2014-02-14)
Warts, hypogammaglobulinemia, infections, and myelokathexis (WHIM) syndrome is a rare immunodeficiency disorder caused by gain-of-function mutations in the G protein-coupled chemokine receptor CXCR4. The CXCR4 antagonist plerixafor, which is approved by the US Food and Drug Administration (FDA) for stem
Christine Feig et al.
Proceedings of the National Academy of Sciences of the United States of America, 110(50), 20212-20217 (2013-11-28)
An autochthonous model of pancreatic ductal adenocarcinoma (PDA) permitted the analysis of why immunotherapy is ineffective in this human disease. Despite finding that PDA-bearing mice had cancer cell-specific CD8(+) T cells, the mice, like human patients with PDA, did not
Sapna Devi et al.
The Journal of experimental medicine, 210(11), 2321-2336 (2013-10-02)
Blood neutrophil homeostasis is essential for successful host defense against invading pathogens. Circulating neutrophil counts are positively regulated by CXCR2 signaling and negatively regulated by the CXCR4-CXCL12 axis. In particular, G-CSF, a known CXCR2 signaler, and plerixafor, a CXCR4 antagonist
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Product Information Sheet - A5602

Product Information Sheet

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