A5602
AMD3100 八盐酸盐 水合物
≥97% (NMR), solid, CXCR4 antagonist
别名:
1,1′-[1,4-亚苯基双（亚甲基）]双-1,4,8,11-四氮杂 八盐酸盐, JM3100, SID791, 普乐沙福
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关于此项目
经验公式（希尔记法）:
C28H54N8 · 8HCl · xH2O
化学文摘社编号:
分子量:
794.47 (anhydrous basis)
MDL number:
UNSPSC Code:
51111800
PubChem Substance ID:
NACRES:
NA.77
产品名称
AMD3100 八盐酸盐 水合物, ≥97% (NMR), solid
Quality Level
assay
≥97% (NMR)
form
solid
storage condition
desiccated
solubility
H2O: ≥10 mg/mL, clear
originator
Sanofi Aventis
storage temp.
−20°C
SMILES string
Cl[H].Cl[H].Cl[H].Cl[H].Cl[H].Cl[H].Cl[H].Cl[H].[H]O[H].C1CNCCNCCCN(CCNC1)Cc2ccc(CN3CCCNCCNCCCNCC3)cc2
InChI
1S/C28H54N8.8ClH.H2O/c1-9-29-15-17-31-13-3-21-35(23-19-33-11-1)25-27-5-7-28(8-6-27)26-36-22-4-14-32-18-16-30-10-2-12-34-20-24-36;;;;;;;;;/h5-8,29-34H,1-4,9-26H2;8*1H;1H2
InChI key
GKFHDCZYJHUPEN-UHFFFAOYSA-N
Application
AMD3100是一种高度特异性的趋化因子受体CXCR4的拮抗剂。 AMD3100已被用于一项研究，以确定其对口腔鳞状细胞癌中CXCR4的阻断和对淋巴结转移的抑制。
Biochem/physiol Actions
AMD3100是一种高度特异性的趋化因子受体CXCR4的拮抗剂。
Features and Benefits
该化合物是由 Sanofi Aventis开发。浏览其他医药开发的化合物和已批准的药物/候选药物清单，请点击这里。
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
相关内容
Product Information Sheet
Kelli P A MacDonald et al.
Journal of immunology (Baltimore, Md. : 1950), 192(7), 3180-3189 (2014-03-04)
The majority of allogeneic stem cell transplants are currently undertaken using G-CSF mobilized peripheral blood stem cells. G-CSF has diverse biological effects on a broad range of cells and IL-10 is a key regulator of many of these effects. Using
Christine Feig et al.
Proceedings of the National Academy of Sciences of the United States of America, 110(50), 20212-20217 (2013-11-28)
An autochthonous model of pancreatic ductal adenocarcinoma (PDA) permitted the analysis of why immunotherapy is ineffective in this human disease. Despite finding that PDA-bearing mice had cancer cell-specific CD8(+) T cells, the mice, like human patients with PDA, did not
Sapna Devi et al.
The Journal of experimental medicine, 210(11), 2321-2336 (2013-10-02)
Blood neutrophil homeostasis is essential for successful host defense against invading pathogens. Circulating neutrophil counts are positively regulated by CXCR2 signaling and negatively regulated by the CXCR4-CXCL12 axis. In particular, G-CSF, a known CXCR2 signaler, and plerixafor, a CXCR4 antagonist
全球贸易项目编号
| 货号 | GTIN |
|---|---|
| A5602-5MG | 04061833376096 |