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检测方案
≥90% (HPLC)
形式
powder
颜色
yellow
mp
269-270 °C
溶解性
DMSO: soluble
ethanol: soluble
储存温度
2-8°C
SMILES字符串
COc1cccc2c1cc([N+]([O-])=O)c3c(cc4OCOc4c23)C(O)=O
InChI
1S/C17H11NO7/c1-23-12-4-2-3-8-9(12)5-11(18(21)22)14-10(17(19)20)6-13-16(15(8)14)25-7-24-13/h2-6H,7H2,1H3,(H,19,20)
InChI key
BBFQZRXNYIEMAW-UHFFFAOYSA-N
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一般描述
马兜铃酸是一种天然植物代谢物，存在于马兜铃属、Bragantia属或细辛属植物中。它包括硝基菲羧酸（如马兜铃酸I和II）的混合物。
应用
马兜铃酸I 已用于：
- 作为标准品，通过高效液相色谱法分析云杉马兜铃粗提物
- 研究对组蛋白去乙酰化酶3（HDAC3）畸变和肾纤维化的影响
- 诱导急性马兜铃酸肾病，研究对小鼠miRNA和mRNA表达的影响
生化/生理作用
马兜铃酸是蛇毒中磷脂酶A2（PLA2）、透明质酸酶和乙酰胆碱酯酶血浆蛋白酶的有效抑制剂。马兜铃酸被认为是一种草药，对产科、蛇咬伤、痛风和风湿病有治疗作用。它具有抗炎和抗疟疾的特性。此外，它还被认为是一种基因毒性诱变原，可引起马兜铃酸肾病（AAN），特征为间质纤维化和尿路上皮癌。
有效的磷脂酶A2 抑制剂，包括钙离子载体诱导的嗜中性粒细胞磷脂酶A2 活性。实验动物模型的肾肿瘤引发剂。
警示用语：
Danger
危险声明
危险分类
Acute Tox. 3 Oral - Carc. 1A - Muta. 1B
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges
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