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Merck
CN

A5486

Sigma-Aldrich

偶氮甲烷

13.4 M, ≥98%

别名:

AOM

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About This Item

线性分子式:
CH3N=N(→O)CH3
CAS号:
分子量:
74.08
MDL编号:
UNSPSC代码:
12352124
PubChem化学物质编号:
NACRES:
NA.25

质量水平

检测方案

≥98%

形式

liquid

组成

methylene chloride, ≤1% (solvent)

储存条件

(Keep container tightly closed in a dry and well-ventilated place.)

浓度

13.4 M

颜色

colorless

bp

97-99 °C (lit.)

密度

0.991 g/mL at 25 °C (lit.)

应用

genomic analysis

储存温度

−20°C

SMILES字符串

C\N=[N+](/C)[O-]

InChI

1S/C2H6N2O/c1-3-4(2)5/h1-2H3/b4-3+

InChI key

DGAKHGXRMXWHBX-ONEGZZNKSA-N

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一般描述

偶氮甲烷(AOM)是一种功能强大的实验室化学品,用于研究癌症,特别是结肠癌的发生、进展和预防。它可用作引发肿瘤形成的致癌物和导致DNA特异性改变的基因突变剂。

应用

氧化偶氮甲烷(AOM),一种基因突变剂,可与硫酸葡聚糖钠(DSS)一起用于在实验室动物中创建癌症模型,从而用于研究癌症进展和化学预防的机制。

生化/生理作用

诱导DNA中O6-甲基鸟嘌呤加合物的致癌物导致G→A转变。 在实验动物的结肠中诱导肿瘤生成,并用于研究癌症进展和化学预防的机制。

特点和优势

用途广泛,适用于各种实验室和研究应用。

其他说明

为避免实验动物过早死亡,在实验设计中确定合适的氧化偶氮甲烷剂量至关重要。
如需了解生化试剂系列的更多信息,请填写此表

相关产品

产品编号
说明
价格

警示用语:

Danger

危险分类

Acute Tox. 2 Oral - Carc. 1B - Eye Irrit. 2 - Flam. Liq. 3 - Skin Irrit. 2

WGK

WGK 3

闪点(°F)

75.2 °F

闪点(°C)

24 °C

法规信息

危险化学品

分析证书(COA)

输入产品批号来搜索 分析证书(COA) 。批号可以在产品标签上"批“ (Lot或Batch)字后找到。

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  1. How does the storage temperature relate to shipping conditions?

    The storage conditions that a Sigma-Aldrich catalog and label recommend for products are deliberately conservative. For many products, long-term storage at low temperatures will increase the time during which they are expected to remain in specification and therefore are labeled accordingly. Where short-term storage, shipping time frame, or exposure to conditions other than those recommended for long-term storage will not affect product quality, Sigma-Aldrich will ship at ambient temperature. The products sensitive to short-term exposure to conditions other than their recommended long-term storage are shipped on wet or dry ice. Ambient temperature shipping helps to control shipping costs for our customers. At any time, our customers can request wet- or dry-ice shipment, but the special handling is at customer expense if our product history indicates that the product is stable for regular shipment. See Shipping and Storage for more information.

  2. Which document(s) contains shelf-life or expiration date information for a given product?

    If available for a given product, the recommended re-test date or the expiration date can be found on the Certificate of Analysis.

  3. How do I get lot-specific information or a Certificate of Analysis?

    The lot specific COA document can be found by entering the lot number above under the "Documents" section.

  4. How do I find price and availability?

    There are several ways to find pricing and availability for our products. Once you log onto our website, you will find the price and availability displayed on the product detail page. You can contact any of our Customer Sales and Service offices to receive a quote.  USA customers:  1-800-325-3010 or view local office numbers.

  5. What is the Department of Transportation shipping information for this product?

    Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product. 

  6. What solvents can be used to dissolve Azoxymethane?

    Azoxymethane is soluble in water, ether, ethanol, and chloroform. The reported solubility in chlorform is 200 mg/mL, and in water is 100 mg/mL.

  7. How should stock solutions of Azoxymethane be stored, and for how long can they be kept?

    No solution stability studies have been performed by Sigma-Aldrich. Because the solution stability is unknown, solutions should be prepared fresh for use.

  8. How does azoxymethane act to cause cancers?

    Azoxymethane is a methylating agent which forms 6-O-methylguanine in DNA.  Unless this methylated base is repaired by cellular enzymes, it results in a base mismatch that subsequently causes tumors in the tissue.

  9. What are the approximate volumes for the of 25 mg and 100 mg, package sizes of Product No. A5486, Azoxymethane?

    Using the literature value for density of approximately 0.991 g/mL (at 25 °C), the approximate volumes are 25 μL for the 25 mg package size and 100 μl for the 100 mg package size.

  10. My question is not addressed here, how can I contact Technical Service for assistance?

    Ask a Scientist here.

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