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Merck
CN

A5095

Sigma-Aldrich

N-Acetyl-Val-Glu-Ile-Asp-7-amido-4-trifluoromethylcoumarin

≥97% (HPLC), powder

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别名:
Ac-VEID-AFC
线性分子式:
C32H40N5O11F3
分子量:
727.68
MDL编号:
UNSPSC代码:
12352209
PubChem化学物质编号:
NACRES:
NA.32

质量水平

检测方案

≥97% (HPLC)

形式

powder

溶解性

DMSO/DMF: 20 mM

储存温度

−20°C

SMILES字符串

CC[C@H](C)[C@H](NC(=O)[C@H](CCC(O)=O)NC(=O)[C@@H](NC(=O)OCc1ccccc1)C(C)C)C(=O)N[C@@H](CC(O)=O)C(=O)Nc2ccc3c(OC(=O)C=C3C(F)(F)F)c2

InChI

1S/C38H44F3N5O12/c1-5-20(4)32(36(55)44-26(17-29(49)50)34(53)42-22-11-12-23-24(38(39,40)41)16-30(51)58-27(23)15-22)45-33(52)25(13-14-28(47)48)43-35(54)31(19(2)3)46-37(56)57-18-21-9-7-6-8-10-21/h6-12,15-16,19-20,25-26,31-32H,5,13-14,17-18H2,1-4H3,(H,42,53)(H,43,54)(H,44,55)(H,45,52)(H,46,56)(H,47,48)(H,49,50)/t20-,25-,26-,31-,32-/m0/s1

InChI key

OEVAAZFKVRJQQH-UXAYAQJLSA-N

基因信息

human ... CASP6(839)

Amino Acid Sequence

NAc-Val-Glu-Ile-Asp-AFC

生化/生理作用

Fluorogenic substrate for caspase 6 (Mch-2α).

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

Eyeshields, Gloves, type N95 (US)

法规信息

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A Takahashi et al.
Proceedings of the National Academy of Sciences of the United States of America, 93(16), 8395-8400 (1996-08-06)
Although proteases related to the interleukin 1 beta-converting enzyme (ICE) are known to be essential for apoptotic execution, the number of enzymes involved, their substrate specificities, and their specific roles in the characteristic biochemical and morphological changes of apoptosis are
R V Talanian et al.
The Journal of biological chemistry, 272(15), 9677-9682 (1997-04-11)
The caspase family represents a new class of intracellular cysteine proteases with known or suspected roles in cytokine maturation and apoptosis. These enzymes display a preference for Asp in the P1 position of substrates. To clarify differences in the biological
Ilona Domracheva et al.
Life sciences, 186, 92-101 (2017-08-16)
This study was designed to investigate the mechanism underlying cancer cell apoptosis caused by selenophenoquinolinones and coumarins. Twelve derivatives were studied according to their ability to suppress the proliferation of cancer cells in vitro (i.e., HepG2, MH-22A, MCF-7), induce cell

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