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Merck
CN

A5095

N-Acetyl-Val-Glu-Ile-Asp-7-amido-4-trifluoromethylcoumarin

≥97% (HPLC), powder

别名:

Ac-VEID-AFC

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关于此项目

线性分子式:
C32H40N5O11F3
分子量:
727.68
NACRES:
NA.32
PubChem Substance ID:
UNSPSC Code:
12352209
MDL number:
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产品名称

N-Acetyl-Val-Glu-Ile-Asp-7-amido-4-trifluoromethylcoumarin, ≥97% (HPLC), powder

InChI

1S/C38H44F3N5O12/c1-5-20(4)32(36(55)44-26(17-29(49)50)34(53)42-22-11-12-23-24(38(39,40)41)16-30(51)58-27(23)15-22)45-33(52)25(13-14-28(47)48)43-35(54)31(19(2)3)46-37(56)57-18-21-9-7-6-8-10-21/h6-12,15-16,19-20,25-26,31-32H,5,13-14,17-18H2,1-4H3,(H,42,53)(H,43,54)(H,44,55)(H,45,52)(H,46,56)(H,47,48)(H,49,50)/t20-,25-,26-,31-,32-/m0/s1

SMILES string

CC[C@H](C)[C@H](NC(=O)[C@H](CCC(O)=O)NC(=O)[C@@H](NC(=O)OCc1ccccc1)C(C)C)C(=O)N[C@@H](CC(O)=O)C(=O)Nc2ccc3c(OC(=O)C=C3C(F)(F)F)c2

InChI key

OEVAAZFKVRJQQH-UXAYAQJLSA-N

assay

≥97% (HPLC)

form

powder

solubility

DMSO/DMF: 20 mM

storage temp.

−20°C

Quality Level

Gene Information

human ... CASP6(839)

Biochem/physiol Actions

Fluorogenic substrate for caspase 6 (Mch-2α).

存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

法规信息

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历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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A Takahashi et al.
Proceedings of the National Academy of Sciences of the United States of America, 93(16), 8395-8400 (1996-08-06)
Although proteases related to the interleukin 1 beta-converting enzyme (ICE) are known to be essential for apoptotic execution, the number of enzymes involved, their substrate specificities, and their specific roles in the characteristic biochemical and morphological changes of apoptosis are
R V Talanian et al.
The Journal of biological chemistry, 272(15), 9677-9682 (1997-04-11)
The caspase family represents a new class of intracellular cysteine proteases with known or suspected roles in cytokine maturation and apoptosis. These enzymes display a preference for Asp in the P1 position of substrates. To clarify differences in the biological
Ilona Domracheva et al.
Life sciences, 186, 92-101 (2017-08-16)
This study was designed to investigate the mechanism underlying cancer cell apoptosis caused by selenophenoquinolinones and coumarins. Twelve derivatives were studied according to their ability to suppress the proliferation of cancer cells in vitro (i.e., HepG2, MH-22A, MCF-7), induce cell

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