A4941
激活素 A 人
≥95% (SDS-PAGE), recombinant, expressed in baculovirus infected insect cells, lyophilized powder, suitable for cell culture
别名:
人生长因子, 激活素A蛋白, 生长因子
产品名称
激活素 A 人, ≥95% (SDS-PAGE), recombinant, expressed in baculovirus infected insect cells, lyophilized powder, suitable for cell culture
biological source
human
recombinant
expressed in baculovirus infected insect cells
assay
≥95% (SDS-PAGE)
form
lyophilized powder
potency
1-10 ng/mL ED50
mol wt
dimer 26 kDa (containing 116 amino acid residues βA subunits)
packaging
pkg of 10 μg
pkg of 5 μg
technique(s)
cell culture | mammalian: suitable
impurities
endotoxin, tested
UniProt accession no.
storage temp.
−20°C
Quality Level
Gene Information
human ... INHBA(3624)
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Analysis Note
其生物活性由其抑制小鼠 MPC-11 细胞增殖的能力决定。
Application
人激活素A已被用作 modified barth′s saline 的成分，用于体外诱导前肾。它还被用作罗斯威尔公园纪念研究所（RPMI）培养基的成分，用于在体外诱导多能真皮成纤维细胞的胰腺分化。
Biochem/physiol Actions
激活素在激素生成、细胞稳态和分化程序的调节中起着至关重要的作用。激活素A和B的表达升高会导致肌肉质量下降。激活素A和B都有望用作慢性疲劳综合征/肌痛性脑脊髓炎（CFS / ME）的血清标志物。
General description
带有两个外显子的激活素A基因位于人染色体2q35上。激活素A也称为抑制素α-亚基，属于蛋白质的TGF-β（转化生长因子β）超家族，其表达仅限于性腺、胎盘和肾上腺皮质。
Physical form
0.2μ 冻干10 mM 柠檬酸钠 (pH 3.0) 滤过溶液。
signalword
Warning
hcodes
Hazard Classifications
Eye Irrit. 2 - STOT SE 3
target_organs
Respiratory system
存储类别
11 - Combustible Solids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
涉药品监管产品
此项目有
Activin B is a novel biomarker for chronic fatigue syndrome/myalgic encephalomyelitis (CFS/ME) diagnosis: a cross sectional study
Lidbury BA, et al.
Journal of Translational Medicine, 15 (2017)
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Hofland J, et al.
PLoS ONE, 9, e104944-e104944 (2014)
Differentiation of human multipotent dermal fibroblasts into islet-like cell clusters
Bi D, et al.
BMC Cell Biology, 11, 1-7 (2010)
T K Woodruff
Biochemical pharmacology, 55(7), 953-963 (1998-05-30)
Activin is an important molecule that regulates hormonogenesis, cellular homeostasis (divide or die pathways), and differentiation programs (developmentally and in adult cells). The cellular mechanisms that integrate an activin signal into a physiological response include a binary receptor complex and
Valérie Bello et al.
Developmental biology, 317(1), 106-120 (2008-04-02)
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商品
Naive pluripotent stem cells cultured in vitro using specialized media and inhibitors mimic "ground-state" cells from blastocysts.
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