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Merck
CN

A4941

Sigma-Aldrich

激活素 A 人

≥95% (SDS-PAGE), recombinant, expressed in baculovirus infected insect cells, lyophilized powder, suitable for cell culture

别名:

Activin A Protein, Growth Factor, Human Growth Factor

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About This Item

EC 号:
MDL编号:
UNSPSC代码:
12352202
NACRES:
NA.32

生物来源

human

质量水平

重组

expressed in baculovirus infected insect cells

检测方案

≥95% (SDS-PAGE)

形式

lyophilized powder

效能

1-10 ng/mL ED50

分子量

dimer 26 kDa (containing 116 amino acid residues βA subunits)

包装

pkg of 10 μg
pkg of 5 μg

技术

cell culture | mammalian: suitable

杂质

endotoxin, tested

UniProt登记号

储存温度

−20°C

基因信息

human ... INHBA(3624)

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一般描述

带有两个外显子的激活素A基因位于人染色体2q35上。激活素A也称为抑制素α-亚基,属于蛋白质的TGF-β(转化生长因子β)超家族,其表达仅限于性腺、胎盘和肾上腺皮质。

应用

人激活素A已被用作 modified barth′s saline 的成分,用于体外诱导前肾。它还被用作罗斯威尔公园纪念研究所(RPMI)培养基的成分,用于在体外诱导多能真皮成纤维细胞的胰腺分化。

生化/生理作用

激活素在激素生成、细胞稳态和分化程序的调节中起着至关重要的作用。激活素A和B的表达升高会导致肌肉质量下降。激活素A和B都有望用作慢性疲劳综合征/肌痛性脑脊髓炎(CFS / ME)的血清标志物。

外形

0.2μ 冻干10 mM 柠檬酸钠 (pH 3.0) 滤过溶液。

分析说明

其生物活性由其抑制小鼠 MPC-11 细胞增殖的能力决定。

象形图

Exclamation mark

警示用语:

Warning

危险声明

危险分类

Eye Irrit. 2 - STOT SE 3

靶器官

Respiratory system

WGK

WGK 1

闪点(°F)

Not applicable

闪点(°C)

Not applicable

法规信息

监管及禁止进口产品

分析证书(COA)

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Differentiation of human multipotent dermal fibroblasts into islet-like cell clusters
Bi D, et al.
BMC Cell Biology, 11, 1-7 (2010)
Inhibin Alpha-Subunit (INHA) Expression in Adrenocortical Cancer Is Linked to Genetic and Epigenetic INHA Promoter Variation
Hofland J, et al.
PLoS ONE, 9, e104944-e104944 (2014)
Activin B is a novel biomarker for chronic fatigue syndrome/myalgic encephalomyelitis (CFS/ME) diagnosis: a cross sectional study
Lidbury BA, et al.
Journal of Translational Medicine, 15 (2017)
T K Woodruff
Biochemical pharmacology, 55(7), 953-963 (1998-05-30)
Activin is an important molecule that regulates hormonogenesis, cellular homeostasis (divide or die pathways), and differentiation programs (developmentally and in adult cells). The cellular mechanisms that integrate an activin signal into a physiological response include a binary receptor complex and
Valérie Bello et al.
Developmental biology, 317(1), 106-120 (2008-04-02)
Dystroglycan (Dg) is a laminin receptor that is expressed at the interface between the basement membrane and the cell membrane. Dg has been reported to play a role in skeletal muscle cell stability, morphogenesis of neuroepithelial tissues, and in regulating

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