生物来源
human
质量水平
重组
expressed in baculovirus infected insect cells
检测方案
≥95% (SDS-PAGE)
形式
lyophilized powder
效能
1-10 ng/mL ED50
分子量
dimer 26 kDa (containing 116 amino acid residues βA subunits)
包装
pkg of 10 μg
pkg of 5 μg
技术
cell culture | mammalian: suitable
杂质
endotoxin, tested
UniProt登记号
储存温度
−20°C
基因信息
human ... INHBA(3624)
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一般描述
带有两个外显子的激活素A基因位于人染色体2q35上。激活素A也称为抑制素α-亚基,属于蛋白质的TGF-β(转化生长因子β)超家族,其表达仅限于性腺、胎盘和肾上腺皮质。
应用
人激活素A已被用作 modified barth′s saline 的成分,用于体外诱导前肾。它还被用作罗斯威尔公园纪念研究所(RPMI)培养基的成分,用于在体外诱导多能真皮成纤维细胞的胰腺分化。
生化/生理作用
激活素在激素生成、细胞稳态和分化程序的调节中起着至关重要的作用。激活素A和B的表达升高会导致肌肉质量下降。激活素A和B都有望用作慢性疲劳综合征/肌痛性脑脊髓炎(CFS / ME)的血清标志物。
外形
0.2μ 冻干10 mM 柠檬酸钠 (pH 3.0) 滤过溶液。
分析说明
其生物活性由其抑制小鼠 MPC-11 细胞增殖的能力决定。
警示用语:
Warning
危险声明
危险分类
Eye Irrit. 2 - STOT SE 3
靶器官
Respiratory system
WGK
WGK 1
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
监管及禁止进口产品
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Naive pluripotent stem cells cultured in vitro using specialized media and inhibitors mimic "ground-state" cells from blastocysts.
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