A4669
阿昔洛韦
≥99% (HPLC), DNA polymerase inhibitor, powder
别名:
9-[(2-羟基乙氧基)甲基]鸟嘌呤, 阿苷洛韦
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关于此项目
经验公式（希尔记法）:
C8H11N5O3
化学文摘社编号:
分子量:
225.20
EC 号:
MDL编号:
UNSPSC代码:
12352200
PubChem化学物质编号:
NACRES:
NA.77
产品名称
阿昔洛韦, ≥99% (HPLC), powder
质量水平
方案
≥99% (HPLC)
表单
powder
颜色
white
溶解性
H2O: 0.7 mg/mL
1 M HCl: 50 mg/mL
DMSO: 7 mg/mL
ε (消光系数)
11.8 at 256 nm at 1 mM
抗生素抗菌谱
viruses
作用机制
DNA synthesis | interferes
创始人
GlaxoSmithKline
SMILES字符串
NC1=Nc2c(ncn2COCCO)C(=O)N1
InChI
1S/C8H11N5O3/c9-8-11-6-5(7(15)12-8)10-3-13(6)4-16-2-1-14/h3,14H,1-2,4H2,(H3,9,11,12,15)
InChI key
MKUXAQIIEYXACX-UHFFFAOYSA-N
基因信息
human ... HV1S(3365), NP(4860)
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相关类别
一般描述
无环鸟苷或阿昔洛韦是一种鸟苷类似物。
应用
阿昔洛韦作为I型单纯疱疹病毒抑制剂的应用实例：
- 作为阳性对照，通过Vero细胞毒性检测法比较蘑菇提取物的抗病毒活性
- 在感染研究中，检测其对人背根神经节来源神经元(HD10.6)细胞的电压门控钠离子通道(VGSC)的影响
- 检测其对人包皮成纤维细胞的干扰素刺激基因(ISG)表达诱导（Mx1和ISG15）的影响
生化/生理作用
阿昔洛韦是一种抗病毒药，在单纯疱疹病毒胸苷激酶(HSV-TK)的作用下变成三磷酸阿昔洛韦。它竞争性地抑制病毒DNA聚合酶。它对巨细胞病毒和EB(Epstein-Barr)病毒的疗效相对较弱。阿昔洛韦已被用来研究单纯疱疹病毒的潜伏机制。它也具有抗人免疫缺陷型病毒1(HIV-1)活性。
特点和优势
该化合物由GlaxoSmithKline开发。要浏览其他药物开发化合物和批准的药物/候选药物列表，单击此处。
这种化合物是ADME毒性研究的特色产品。点击此处发现更多特色ADME毒性产品。在sigma.com/discover-bsm可了解更多关于生物活性小分子的其他研究领域。
储存分类代码
11 - Combustible Solids
WGK
WGK 2
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, type N95 (US)
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