A4438
p-Acetamidophenyl β-D-glucuronide sodium salt
>98% (TLC)
别名:
Acetaminophen glucuronide, Paracetamol glucuronide
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线性分子式:
C14H16NO8Na
化学文摘社编号:
分子量:
349.27
NACRES:
NA.25
PubChem Substance ID:
UNSPSC Code:
12352201
MDL number:
产品名称
p-Acetamidophenyl β-D-glucuronide sodium salt, >98% (TLC)
InChI
1S/C14H17NO8.Na/c1-6(16)15-7-2-4-8(5-3-7)22-14-11(19)9(17)10(18)12(23-14)13(20)21;/h2-5,9-12,14,17-19H,1H3,(H,15,16)(H,20,21);/q;+1/p-1/t9-,10-,11+,12-,14+;/m0./s1
SMILES string
[Na+].CC(=O)Nc1ccc(O[C@@H]2O[C@@H]([C@@H](O)[C@H](O)[C@H]2O)C([O-])=O)cc1
InChI key
OINXIJJEOMGKPB-CYRSAHDMSA-M
assay
>98% (TLC)
form
powder
impurities
<6% water (Karl Fischer)
color
white to off-white
solubility
water: 25 mg/mL, clear, colorless to light yellow
storage temp.
−20°C
Quality Level
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Application
Acetaminophen glucuronide (AA-Gluc) is used as a reference material in procedures that analyse urine and plasma for acetaminophen metabolites to indicate hepatotoxicity.
Other Notes
To gain a comprehensive understanding of our extensive range of Monosaccharides for your research, we encourage you to visit our Carbohydrates Category page.
wgk
WGK 3
存储类别
11 - Combustible Solids
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
Carol R Gardner et al.
Toxicological sciences : an official journal of the Society of Toxicology, 125(2), 607-612 (2011-11-04)
Fenbendazole is a broad-spectrum anthelmintic drug widely used to prevent or treat nematode infections in laboratory rodent colonies. Potential interactions between fenbendazole and hepatotoxicants such as acetaminophen are unknown, and this was investigated in this study. Mice were fed a
T Andrew Clayton et al.
Proceedings of the National Academy of Sciences of the United States of America, 106(34), 14728-14733 (2009-08-12)
We provide a demonstration in humans of the principle of pharmacometabonomics by showing a clear connection between an individual's metabolic phenotype, in the form of a predose urinary metabolite profile, and the metabolic fate of a standard dose of the
Scott A Reisman et al.
Toxicological sciences : an official journal of the Society of Toxicology, 109(1), 31-40 (2009-02-28)
Acetaminophen (AA) is a widely used antipyretic drug that causes hepatotoxicity at high doses. Nuclear factor erythroid 2-related factor 2 (Nrf2) is a transcription factor that mitigates electrophilic stress from AA by inducing genes, such as NAD(P)H:quinone oxidoreductase 1 (Nqo1)
Mayu Kakehi et al.
Toxicological sciences : an official journal of the Society of Toxicology, 147(2), 360-369 (2015-07-17)
There are various interspecies differences in xenobiotic-metabolizing enzymes. It is known that cats show slow glucuronidation of drugs such as acetaminophen and strong side effects due to the UGT1A6 pseudogene. Recently, the UGT1A6 pseudogene was found in the Northern elephant
Andrew Rowland et al.
Drug metabolism and disposition: the biological fate of chemicals, 43(1), 147-153 (2014-11-09)
This study characterized the kinetics, variability, and factors that affect UDP-glucuronic acid (UDP-GlcUA) uptake by human liver microsomes (HLM). Biphasic kinetics were observed for UDP-GlcUA uptake by HLM. Uptake affinities (assessed as Kd) of the high- and low-affinity components differed
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