A4330
4′-氨甲基三氧沙林 盐酸盐
DNA and RNA virus inactivator, powder
别名:
4＆＃8242;氨基甲基-4,5-＆＃8242;，8三甲基补骨脂 盐酸盐
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关于此项目
经验公式（希尔记法）:
C15H15NO3 · HCl
化学文摘社编号:
分子量:
293.75
UNSPSC Code:
12352200
PubChem Substance ID:
NACRES:
NA.77
MDL number:
Application
4'-盐酸氨甲基三氧沙林可灭活 DNA 和 RNA 病毒，包括 HIV-1。4'-盐酸氨甲基三氧沙林在紫外光照射下可与核酸共价结合。
Biochem/physiol Actions
4'-盐酸氨甲基三氧沙林用于通过核酸交联和紫外线照射灭活 DNA 和 RNA 病毒，包括 HIV-1。
Features and Benefits
这种化合物是细胞凋亡研究的特色产品。 点击此处 ，发现更多特色细胞凋亡产品。访问sigma.com/discover-bsm了解更多关于其他研究领域的生物活性小分子的信息。
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Danger
Hazard Classifications
Acute Tox. 4 Oral - Carc. 2 - Skin Corr. 1B
存储类别
8A - Combustible corrosive hazardous materials
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges
Ryan C Maves et al.
Vaccine, 29(15), 2691-2696 (2011-02-10)
Psoralens are photoreactive compounds that cross-link pyrimidines after exposure to UVA radiation. In this experiment, we tested the protective efficacy of a psoralen-inactivated dengue vaccine candidate in non-human primates. Two groups of 7 Aotus nancymaae monkeys received either 10ng per
A A Oroskar et al.
Free radical biology & medicine, 20(5), 751-756 (1996-01-01)
The ability of scavengers of hydroxyl radical (OH radical) to modulate the photosensitized relaxation (induction of the first single-strand break) of supercoiled plasmid DNA with UVA photoactivated 4'-aminomethyl-4,5',8-trimethylpsoralen was examined by comparing the dose reduction factor (DRF: the ratio of
M A Reynolds et al.
Bioconjugate chemistry, 3(5), 366-374 (1992-09-11)
A method is reported for conjugating an analog of 4'-(aminomethyl)-4,5',8- trimethylpsoralen to methylphophonate oligonucleotides. This method enables the psoralen moiety to be coupled to the phosphonate backbone between any two desired bases in a sequence. When hybridized to a target
W S Groene et al.
Journal of virological methods, 38(1), 93-102 (1992-07-01)
The use of the synthetic psoralen 4'-aminomethyl-4,5',8-trimethylpsoralen hydrochloride (AMT) is described for the inactivation of infectious rotavirus, a member of the viral family Reoviradae with a double-stranded RNA genome. This method not only provides complete inactivation of the virus but
M Beltrame et al.
The EMBO journal, 11(4), 1531-1542 (1992-04-01)
It has long been known that U3 can be isolated hydrogen bonded to pre-ribosomal RNAs, but the sites of interaction are poorly characterized. Here we show that yeast U3 can be cross-linked to 35S pre-rRNA both in deproteinized extracts and
商品
DNA damage and repair mechanism is vital for maintaining DNA integrity. Damage to cellular DNA is involved in mutagenesis, the development of cancer among others.
Cell cycle phases (G1, S, G2, M) regulate cell growth, DNA replication, and division in proliferating cells.
Apoptosis regulation involves multiple pathways and molecules for cellular homeostasis.
DNA损伤和修复机制对于维持DNA完整性至关重要。细胞DNA的损伤与突变、癌症发展等有关。
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