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A4330

Sigma-Aldrich

4'-氨甲基三氧沙林 盐酸盐

别名:

4＆＃8242;氨基甲基-4,5-＆＃8242;，8三甲基补骨脂 盐酸盐

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About This Item

经验公式（希尔记法）:
C15H15NO3 · HCl
CAS号:
62442-61-9
分子量:
293.75
MDL编号:
MFCD00134837
UNSPSC代码:
12352200
PubChem化学物质编号:
24890846
NACRES:
NA.77

表单

powder

质量水平

200

溶解性

H2O: 1 mg/mL
DMSO: 2 mg/mL

储存温度

2-8°C

SMILES字符串

CC1=CC(=O)Oc2c(C)c3oc(C)c(CN)c3cc12

InChI

1S/C15H15NO3/c1-7-4-13(17)19-14-8(2)15-11(5-10(7)14)12(6-16)9(3)18-15/h4-5H,6,16H2,1-3H3

InChI key

WBIICVGYYRRURR-UHFFFAOYSA-N

应用

4'-盐酸氨甲基三氧沙林可灭活 DNA 和 RNA 病毒，包括 HIV-1。4'-盐酸氨甲基三氧沙林在紫外光照射下可与核酸共价结合。

生化/生理作用

4'-盐酸氨甲基三氧沙林用于通过核酸交联和紫外线照射灭活 DNA 和 RNA 病毒，包括 HIV-1。

特点和优势

这种化合物是细胞凋亡研究的特色产品。 点击此处 ，发现更多特色细胞凋亡产品。访问sigma.com/discover-bsm了解更多关于其他研究领域的生物活性小分子的信息。

警示用语：

Danger

危险分类

Acute Tox. 4 Oral - Carc. 2 - Skin Corr. 1B

储存分类代码

8A - Combustible corrosive hazardous materials

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
0000371450
0000371450
0000303630
0000303630
0000180067

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M N Lubaki et al.
AIDS research and human retroviruses, 10(11), 1427-1431 (1994-11-01)
Studies have shown that cytolytic T lymphocyte (CTL) responses may be critical to the clearance of the early viremia in acute HIV-1 infection. It is likely that these cells play an important role in prolonging the asymptomatic phase of the
W A Saffran et al.
Mutation research, 274(1), 1-9 (1992-06-01)
Photoreaction with psoralen, a DNA-crosslinking reagent, induces mitotic recombination in the yeast Saccharomyces cerevisiae. Psoralen damage-induced recombination was studied with non-replicating plasmids, which transform yeast cells by undergoing recombination events with chromosomal DNA. When plasmid DNA was photoreacted with psoralen
D J Hei et al.
Transfusion, 39(3), 239-248 (1999-04-16)
Cytokines generated in platelet concentrates (PCs) during storage have been implicated as possible mediators of febrile nonhemolytic transfusion reactions. Two potential methods of white cell inactivation were compared for their ability to reduce cytokine synthesis in pooled random-donor PC aliquots:
Ryan C Maves et al.
Vaccine, 29(15), 2691-2696 (2011-02-10)
Psoralens are photoreactive compounds that cross-link pyrimidines after exposure to UVA radiation. In this experiment, we tested the protective efficacy of a psoralen-inactivated dengue vaccine candidate in non-human primates. Two groups of 7 Aotus nancymaae monkeys received either 10ng per
A A Oroskar et al.
Free radical biology & medicine, 20(5), 751-756 (1996-01-01)
The ability of scavengers of hydroxyl radical (OH radical) to modulate the photosensitized relaxation (induction of the first single-strand break) of supercoiled plasmid DNA with UVA photoactivated 4'-aminomethyl-4,5',8-trimethylpsoralen was examined by comparing the dose reduction factor (DRF: the ratio of
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