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检测方案
≥98% (TLC)
形式
powder
颜色
white to off-white
应用
cell analysis
SMILES字符串
[Na].Nc1ccc(cc1)C(=O)NCC(O)=O
InChI
1S/C9H10N2O3.Na.H/c10-7-3-1-6(2-4-7)9(14)11-5-8(12)13;;/h1-4H,5,10H2,(H,11,14)(H,12,13);;
InChI key
IGACXVXMVJUFOL-UHFFFAOYSA-N
生化/生理作用
Para-Aminohippuric acid (PAH), OAT-1 specific, is used to help differentiate and characterized organic anion transporter (OAT) isoforms.
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, type N95 (US)
Advances in pharmacological sciences, 2011, 204501-204501 (2011-07-09)
The characteristics of aristolochic acid nephropathy (AAN) are interstitial fibrosis and atrophy of the proximal tubules, but with no change in glomeruli. To investigate the effects of AA on renal functions and the pharmacokinetics (PKs) of p-aminohippuric acid (PAH) and
Journal of veterinary pharmacology and therapeutics, 35(3), 209-215 (2011-06-01)
Mammary epithelial cells express a diversity of membrane transporters including members of organic cation and organic anion (OAT) transporter subfamilies. Four mammal OAT isoforms have been identified: OAT-1, OAT-2, OAT-3, and OAT-4. The pharmacological significance of OAT isoforms has been
Toxicology, 264(1-2), 74-79 (2009-08-01)
Aristolochic acid (AA), present in Aristolochia species, is the major causative agent in the development of severe renal failure and urothelial cancers in patients with AA nephropathy. It may also be a cause of Balkan endemic nephropathy. Epithelial cells of
Biochemical pharmacology, 81(7), 942-949 (2011-01-20)
Flavonoids are conjugated by phase II enzymes in humans to form glucuronidated and sulfated metabolites that are excreted in urine via the kidney. In this study, we examined the interaction between metabolites of quercetin and isoflavonoids found in vivo with
Critical care (London, England), 18(6), 657-657 (2014-11-30)
The aim of this study was to explore changes in glomerular filtration (GFR) and renal tubular function in critically ill patients at risk of augmented renal clearance (ARC), using exogenous marker compounds. This prospective, observational pharmacokinetic (PK) study was performed
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