推荐产品
生物来源
Artemisia annua
质量水平
表单
crystalline powder
颜色
white to off-white
溶解性
acetone: 33.4 mg/mL
抗生素抗菌谱
neoplastics
parasites
作用机制
protein synthesis | interferes
储存温度
room temp
SMILES字符串
O1OC2(O[C@H]3O[C@@H]([C@@H]([C@H]4[C@]31[C@H]([C@@H](CC4)C)CC2)C)OC(=O)CCC(=O)O)C
InChI
1S/C19H28O8/c1-10-4-5-13-11(2)16(23-15(22)7-6-14(20)21)24-17-19(13)12(10)8-9-18(3,25-17)26-27-19/h10-13,16-17H,4-9H2,1-3H3,(H,20,21)/t10-,11-,12+,13+,16+,17-,18?,19-/m1/s1
InChI key
FIHJKUPKCHIPAT-JQXDXKTESA-N
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相关类别
一般描述
青蒿琥酯是青蒿素的半合成衍生物，用于治疗疟疾。 它还经证对其他寄生虫如肝吸虫有效。 青蒿琥酯对不同肿瘤类型的癌细胞也具有细胞毒性作用。
应用
- 揭示青蒿酯在小鼠模型中对新出现的人畜共患微小巴贝虫感染的治疗潜力。: 本研究探讨了青蒿酯治疗小鼠微小巴贝虫感染（一种人畜共患疾病）的功效。研究结果表明，青蒿琥显著降低了寄生虫血症，表明其作为人畜共患感染治疗剂的潜力（Fazilani et al., 2024）。
- 青蒿酯通过细胞周期检查点控制对人食管鳞状细胞癌细胞的抗肿瘤作用。: 该研究考察了青蒿酯在食管鳞状癌细胞中的抗肿瘤特性，强调了其调节细胞周期检查点（checkpoint）和抑制癌症细胞增殖的能力。这些发现强调了青蒿酯在癌症治疗中的潜力(Mao et al., 2024）。
- 用于青蒿酯脉冲释放的多单元胃滞留片的3D打印。: 本研究提出了一种新的药物递送方法，使用3D打印的胃滞留片进行青蒿酯的脉冲式释放。该技术有望提高青蒿酯的生物利用度和治疗各种疾病的疗效（Yan et al., 2024）。
生化/生理作用
青蒿琥酯可作用于电子传递链，产生局部活性氧，引起线粒体膜的去极化 。它可通过抑制人类风湿关节炎成纤维样滑膜细胞中的NF-κB和 PI3 激酶/Akt信号通路，抑制TNF诱导的促炎细胞因子的产生。
其他说明
将容器紧紧地封闭在干燥通风良好的地方。保存在干燥的地方。
警示用语：
Warning
危险分类
Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral
储存分类代码
13 - Non Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
dust mask type N95 (US), Eyeshields, Gloves
历史批次信息供参考:
分析证书(COA)
Lot/Batch Number
Shunyang Fan et al.
Annals of translational medicine, 8(20), 1291-1291 (2020-11-20)
The various anti-inflammatory, anti-apoptotic, and antioxidant effects of Artesunate (Art) have been explored in numerous studies. This study aimed to evaluate the function of Art on myocardial necrosis in apoptotic cardiomyocytes in vivo and in vitro. Sprague Dawley (SD) rats
Wei Li et al.
PLoS genetics, 1(3), e36-e36 (2005-09-20)
Artemisinins, derived from the wormwood herb Artemisia annua, are the most potent antimalarial drugs currently available. Despite extensive research, the exact mode of action of artemisinins has not been established. Here we use yeast, Saccharamyces cerevisiae, to probe the core
H Xu et al.
Rheumatology (Oxford, England), 46(6), 920-926 (2007-02-23)
Recent studies indicate that the anti-malarial agent artemisinin and its derivatives may exert an anti-inflammatory effect. In this study, we explored the effect of artesunate, an artemisinin derivative, on tumour necrosis factor (TNF)-alpha-induced production of interleukins, IL-1beta, IL-6 and IL-8
Weiyu Zhang et al.
Annals of translational medicine, 8(14), 858-858 (2020-08-15)
Prolactinoma is the most common hormone-secreting pituitary adenoma. Dopamine receptor agonists (DAs) are effective in reducing prolactin levels and tumor mass, but some prolactinoma patients are resistant to DAs. Treating patients with DA-resistant prolactinoma is challenging. In this study, we
Erica L L Warkus et al.
Toxicological sciences : an official journal of the Society of Toxicology, 157(1), 235-245 (2017-02-12)
Establishment of effective non-animal alternatives for developmental toxicity screening assays is desirable to ensure maternal and fetal health outcomes. Validation of such assays requires a comparison between the in vitro responses to chemical exposures and the in vivo impacts of
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