推荐产品
生物来源
Artemisia annua
质量水平
表单
crystalline powder
颜色
white to off-white
溶解性
acetone: 33.4 mg/mL
抗生素抗菌谱
neoplastics
parasites
作用机制
protein synthesis | interferes
储存温度
room temp
SMILES字符串
O1OC2(O[C@H]3O[C@@H]([C@@H]([C@H]4[C@]31[C@H]([C@@H](CC4)C)CC2)C)OC(=O)CCC(=O)O)C
InChI
1S/C19H28O8/c1-10-4-5-13-11(2)16(23-15(22)7-6-14(20)21)24-17-19(13)12(10)8-9-18(3,25-17)26-27-19/h10-13,16-17H,4-9H2,1-3H3,(H,20,21)/t10-,11-,12+,13+,16+,17-,18?,19-/m1/s1
InChI key
FIHJKUPKCHIPAT-JQXDXKTESA-N
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相关类别
一般描述
青蒿琥酯是青蒿素的半合成衍生物，用于治疗疟疾。 它还经证对其他寄生虫如肝吸虫有效。 青蒿琥酯对不同肿瘤类型的癌细胞也具有细胞毒性作用。
应用
- Unrevealing the therapeutic potential of artesunate against emerging zoonotic Babesia microti infection in the murine model.: This study explores the efficacy of artesunate in treating Babesia microti infection, a zoonotic disease, in mice. The findings suggest that artesunate significantly reduces parasitemia, indicating its potential as a therapeutic agent for zoonotic infections (Fazilani et al., 2024).
- Antitumour effects of artesunate via cell cycle checkpoint controls in human oesophageal squamous carcinoma cells.: The study investigates artesunate′s antitumor properties in oesophageal squamous carcinoma cells, highlighting its ability to regulate cell cycle checkpoints and inhibit cancer cell proliferation. These findings underscore artesunate′s potential in cancer therapy (Mao et al., 2024).
- 3D printing of multi-unit gastro-retentive tablets for the pulsatile release of artesunate.: This study presents a novel approach to drug delivery using 3D-printed gastro-retentive tablets for the pulsatile release of artesunate. The technology promises improved bioavailability and therapeutic efficacy of artesunate for various medical conditions (Yan et al., 2024).
生化/生理作用
青蒿琥酯可作用于电子传递链，产生局部活性氧，引起线粒体膜的去极化 。它可通过抑制人类风湿关节炎成纤维样滑膜细胞中的NF-κB和 PI3 激酶/Akt信号通路，抑制TNF诱导的促炎细胞因子的产生。
其他说明
将容器紧紧地封闭在干燥通风良好的地方。保存在干燥的地方。
警示用语：
Warning
危险分类
Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral
储存分类代码
13 - Non Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
dust mask type N95 (US), Eyeshields, Gloves
从最新的版本中选择一种：
分析证书(COA)
Lot/Batch Number
Wei Li et al.
PLoS genetics, 1(3), e36-e36 (2005-09-20)
Artemisinins, derived from the wormwood herb Artemisia annua, are the most potent antimalarial drugs currently available. Despite extensive research, the exact mode of action of artemisinins has not been established. Here we use yeast, Saccharamyces cerevisiae, to probe the core
H Xu et al.
Rheumatology (Oxford, England), 46(6), 920-926 (2007-02-23)
Recent studies indicate that the anti-malarial agent artemisinin and its derivatives may exert an anti-inflammatory effect. In this study, we explored the effect of artesunate, an artemisinin derivative, on tumour necrosis factor (TNF)-alpha-induced production of interleukins, IL-1beta, IL-6 and IL-8
Shunyang Fan et al.
Annals of translational medicine, 8(20), 1291-1291 (2020-11-20)
The various anti-inflammatory, anti-apoptotic, and antioxidant effects of Artesunate (Art) have been explored in numerous studies. This study aimed to evaluate the function of Art on myocardial necrosis in apoptotic cardiomyocytes in vivo and in vitro. Sprague Dawley (SD) rats
Weiyu Zhang et al.
Annals of translational medicine, 8(14), 858-858 (2020-08-15)
Prolactinoma is the most common hormone-secreting pituitary adenoma. Dopamine receptor agonists (DAs) are effective in reducing prolactin levels and tumor mass, but some prolactinoma patients are resistant to DAs. Treating patients with DA-resistant prolactinoma is challenging. In this study, we
Lisa Evans DeWald et al.
Scientific reports, 9(1), 20199-20199 (2019-12-29)
During the Ebola virus disease (EVD) epidemic in Western Africa (2013‒2016), antimalarial treatment was administered to EVD patients due to the high coexisting malaria burden in accordance with World Health Organization guidelines. In an Ebola treatment center in Liberia, EVD patients
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