A3650
阿米卡星 水合物
aminoglycoside antibiotic
别名:
N 1 - [(S)-4-氨基-2-羟基丁酰基] 卡那霉素 A
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关于此项目
经验公式（希尔记法）:
C22H43N5O13 · xH2O
化学文摘社编号:
分子量:
585.60 (anhydrous basis)
Beilstein:
1445422
EC 号:
MDL编号:
UNSPSC代码:
51281632
PubChem化学物质编号:
NACRES:
NA.85
生物来源
synthetic
质量水平
表单
powder
颜色
white to almost white
抗生素抗菌谱
Gram-negative bacteria
mycobacteria
作用机制
protein synthesis | interferes
储存温度
2-8°C
SMILES字符串
O.NCC[C@H](O)C(=O)N[C@@H]1C[C@H](N)[C@@H](O[C@H]2O[C@H](CN)[C@@H](O)[C@H](O)[C@H]2O)[C@H](O)[C@H]1O[C@H]3O[C@H](CO)[C@@H](O)[C@H](N)[C@H]3O
InChI
1S/C22H43N5O13.H2O/c23-2-1-8(29)20(36)27-7-3-6(25)18(39-22-16(34)15(33)13(31)9(4-24)37-22)17(35)19(7)40-21-14(32)11(26)12(30)10(5-28)38-21;/h6-19,21-22,28-35H,1-5,23-26H2,(H,27,36);1H2/t6-,7+,8-,9+,10+,11-,12+,13+,14+,15-,16+,17-,18+,19-,21+,22+;/m0./s1
InChI key
DTSOZYYWEZJFSS-XTHCGPPUSA-N
一般描述
化学结构：氨基糖苷类
应用
阿米卡星水合物用于对诸如 结核分枝杆菌 和 嗜艾利希体 等微生物的抗菌敏感性研究。
生化/生理作用
阿米卡星通过与 30S 核糖体亚基结合，诱导 mRNA 误读，从而抑制细菌蛋白质合成。干扰 tRNA 从 A 位点到 P 位点的移位。
包装
5G
其他说明
保存于密闭容器内，置于干燥通风处。
储存分类代码
11 - Combustible Solids
WGK
WGK 2
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, type N95 (US)
法规信息
涉药品监管产品
此项目有
G J Alangaden et al.
Antimicrobial agents and chemotherapy, 42(5), 1295-1297 (1998-05-21)
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H W Horowitz et al.
Antimicrobial agents and chemotherapy, 45(3), 786-788 (2001-02-22)
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The purpose of this study was to establish a standardized protocol for second-line antimicrobial susceptibility testing of Mycobacterium tuberculosis using the Bactec MGIT 960 system in Canadian laboratories. Four Canadian public health laboratories compared the susceptibility testing results of 9
Sophia B Georghiou et al.
PloS one, 7(3), e33275-e33275 (2012-04-06)
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