推荐产品
应用
αα2-氨基嘌呤已被用于抑制骨关节炎(OA)软骨细胞的真核起始因子2(eIF2)-磷酸化。
2-氨基嘌呤(2-AP)可用于双链RNA依赖性蛋白激酶、蛋白激酶R(PKR)的特异性抑制。
生化/生理作用
2-氨基嘌呤(2AP)是一种鸟苷和腺苷的类似物,可以与胞嘧啶和胸腺嘧啶碱基配对。它可用作核酸结构和动力学分析的荧光探针。2-氨基嘌呤(2-AP)可抑制双链RNA依赖性蛋白激酶蛋白激酶R(PKR)。
警示用语:
Warning
危险声明
危险分类
Acute Tox. 4 Oral
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
dust mask type N95 (US), Eyeshields, Gloves
历史批次信息供参考:
分析证书(COA)
Lot/Batch Number
Endoplasmic reticulum stress induces the expression of COX-2 through activation of eIF2alpha, p38-MAPK and NF-kappaB in advanced glycation end products stimulated human chondrocytes
Rasheed Z and HaqqiTM
Biochimica et Biophysica Acta - Molecular Cell Research, 1823(12), 2179-2189 (2012)
2-Aminopurine.
A Ronen
Mutation research, 75(1), 1-47 (1980-01-01)
Julien Godet et al.
Nucleic acids research, 41(9), 5036-5048 (2013-03-21)
The HIV-1 nucleocapsid protein (NCp7) is a nucleic acid chaperone required during reverse transcription. During the first strand transfer, NCp7 is thought to destabilize cTAR, the (-)DNA copy of the TAR RNA hairpin, and subsequently direct the TAR/cTAR annealing through
Double-Stranded RNA-Dependent Protein Kinase Is Involved in 2-Methoxyestradiol?Mediated Cell Death of Osteosarcoma Cells
Shogren KL, et al.
Journal of Bone and Mineral Research, 22(1), 29-36 (2007)
2-Aminopurine fluorescence quenching and lifetimes: role of base stacking
Jean JM and Hall KB
Proceedings of the National Academy of Sciences of the USA, 98(1), 37-41 (2001)
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