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A3480

阿托西班

Name: 阿托西班
Brand: SIGMA

≥98% (HPLC), oxytocin receptor antagonist, lyophilized powder

别名:

1-(3-巯基丙酸)-2-(O-乙基-D-酪氨酸)-4-L-苏氨酸-8-L-鸟氨酸催产素, 1-脱氨基-2-d-酪氨酸-(O-乙基)-4-苏氨酸-8-鸟氨酸催产素, 醋酸阿托西班

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关于此项目

经验公式（希尔记法）:

C₄₃H₆₇N₁₁O₁₂S₂

化学文摘社编号:

90779-69-4

分子量:

994.19

UNSPSC Code:

51111800

PubChem Substance ID:

24724390

NACRES:

NA.77

MDL number:

MFCD00672436

Assay:

≥98% (HPLC)

Form:

lyophilized powder

Quality level:

100

Storage condition:

desiccated

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属性

产品名称

阿托西班, ≥98% (HPLC)

Quality Level

100

assay

≥98% (HPLC)

form

lyophilized powder

storage condition

desiccated

color

white

solubility

H₂O: ≤100 mg/mL

originator

Ferring

shipped in

wet ice

storage temp.

−20°C

SMILES string

[H][C@]1(NC(=O)[C@@]([H])(NC(=O)[C@@H](Cc2ccc(OCC)cc2)NC(=O)CCSSC[C@H](NC(=O)[C@H](CC(N)=O)NC1=O)C(=O)N3CCC[C@H]3C(=O)N[C@@H](CCCN)C(=O)NCC(N)=O)[C@@H](C)CC)[C@@H](C)O

InChI

1S/C43H67N11O12S2/c1-5-23(3)35-41(63)53-36(24(4)55)42(64)50-29(20-32(45)56)38(60)51-30(43(65)54-17-8-10-31(54)40(62)49-27(9-7-16-44)37(59)47-21-33(46)57)22-68-67-18-15-34(58)48-28(39(61)52-35)19-25-11-13-26(14-12-25)66-6-2/h11-14,23-24,27-31,35-36,55H,5-10,15-22,44H2,1-4H3,(H2,45,56)(H2,46,57)(H,47,59)(H,48,58)(H,49,62)(H,50,64)(H,51,60)(H,52,61)(H,53,63)/t23-,24+,27-,28+,29-,30-,31-,35-,36-/m0/s1

InChI key

VWXRQYYUEIYXCZ-OBIMUBPZSA-N

Gene Information

human ... AVPR1A(552), OXTR(5021)
rat ... Oxtr(25342)

说明

Application

阿托西班已用于：

作为催产素受体拮抗剂
用于子宫肌膜细胞钙离子动员实验的Z-因子测定并作为抑制早产临产的治疗药剂
抑制小鼠臂旁核催产素受体表达神经元(Oxtr^PBN)的活化

Biochem/physiol Actions

阿托西班可高效抑制早产子宫收缩，不会产生任何严重的心血管、肺或中枢神经系统副作用。它可用于治疗早产临产。

阿托西班是一种肽催产素受体拮抗剂。

Features and Benefits

该化合物由Ferring开发。要浏览其他药物开发化合物和批准的药物/候选药物列表，单击此处。

Preparation Note

在去离子水中以不低于100 μg/mL进行重悬，然后可将其稀释成所选的水相载体。溶液可以在2-8℃下储存最长达七天。如需延长储存时间，可加入0.1％人血清白蛋白或牛血清白蛋白的载体蛋白，并按工作用量分装后冻存在−20 °C。

存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

历史批次信息供参考:

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Oxytocin hyperpolarizes cultured duodenum myenteric intrinsic primary afferent neurons by opening BK(Ca) channels through IP₃ pathway.

Tongtong Che et al.

Journal of neurochemistry, 121(4), 516-525 (2012-02-24)

Oxytocin (OT) is clinically important in gut motility and constitutively reduces duodenum contractility. Intrinsic primary afferent neurons (IPANs), whose physiological classification is as AH cells, are the 1st neurons of the peristaltic reflex pathway. We set out to investigate if

Oxytocin regulates changes of extracellular glutamate and GABA levels induced by methamphetamine in the mouse brain.

Jia Qi et al.

Addiction biology, 17(4), 758-769 (2012-04-18)

Oxytocin (OT), a neurohypophyseal neuropeptide, affects adaptive processes of the central nervous system. In the present study, we investigated the effects of OT on extracellular levels of glutamate (Glu) and γ-aminobutyric acid (GABA) induced by methamphetamine (MAP) in the medial

Atosiban, an oxytocin receptor blocking agent: pharmacokinetics and inhibition of milk ejection in dairy cows.

O Wellnitz et al.

The Journal of dairy research, 66(1), 1-8 (1999-04-07)

Plasma concentrations of the oxytocin receptor blocking agent Atosiban were measured at 2, 4, 10, 15 and 20 min after injection of 5, 10, 20 and 50 micrograms Atosiban/kg body weight in six dairy cows. The half life of Atosiban

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货号	GTIN
A3480-10MG	04061833360958