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A3480

Sigma-Aldrich

阿托西班

≥98% (HPLC)

别名:

1-(3-巯基丙酸)-2-(O-乙基-D-酪氨酸)-4-L-苏氨酸-8-L-鸟氨酸催产素, 1-脱氨基-2-d-酪氨酸-(O-乙基)-4-苏氨酸-8-鸟氨酸催产素, 醋酸阿托西班

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About This Item

经验公式（希尔记法）:
C43H67N11O12S2
CAS号:
90779-69-4
分子量:
994.19
MDL编号:
MFCD00672436
UNSPSC代码:
51111800
PubChem化学物质编号:
24724390
NACRES:
NA.77

质量水平

100

方案

≥98% (HPLC)

表单

lyophilized powder

储存条件

desiccated

颜色

white

溶解性

H2O: ≤100 mg/mL

创始人

Ferring

运输

wet ice

储存温度

−20°C

SMILES字符串

[H][C@]1(NC(=O)[C@@]([H])(NC(=O)[C@@H](Cc2ccc(OCC)cc2)NC(=O)CCSSC[C@H](NC(=O)[C@H](CC(N)=O)NC1=O)C(=O)N3CCC[C@H]3C(=O)N[C@@H](CCCN)C(=O)NCC(N)=O)[C@@H](C)CC)[C@@H](C)O

InChI

1S/C43H67N11O12S2/c1-5-23(3)35-41(63)53-36(24(4)55)42(64)50-29(20-32(45)56)38(60)51-30(43(65)54-17-8-10-31(54)40(62)49-27(9-7-16-44)37(59)47-21-33(46)57)22-68-67-18-15-34(58)48-28(39(61)52-35)19-25-11-13-26(14-12-25)66-6-2/h11-14,23-24,27-31,35-36,55H,5-10,15-22,44H2,1-4H3,(H2,45,56)(H2,46,57)(H,47,59)(H,48,58)(H,49,62)(H,50,64)(H,51,60)(H,52,61)(H,53,63)/t23-,24+,27-,28+,29-,30-,31-,35-,36-/m0/s1

InChI key

VWXRQYYUEIYXCZ-OBIMUBPZSA-N

基因信息

human ... AVPR1A(552) , OXTR(5021)
rat ... Oxtr(25342)

应用

阿托西班已用于：
  • 作为催产素受体拮抗剂
  • 用于子宫肌膜细胞钙离子动员实验的Z-因子测定并作为抑制早产临产的治疗药剂
  • 抑制小鼠臂旁核催产素受体表达神经元(OxtrPBN)的活化

生化/生理作用

阿托西班可高效抑制早产子宫收缩，不会产生任何严重的心血管、肺或中枢神经系统副作用。它可用于治疗早产临产。
阿托西班是一种肽催产素受体拮抗剂。

特点和优势

该化合物由Ferring开发。要浏览其他药物开发化合物和批准的药物/候选药物列表，单击此处。

重悬

在去离子水中以不低于100 μg/mL进行重悬，然后可将其稀释成所选的水相载体。溶液可以在2-8℃下储存最长达七天。如需延长储存时间，可加入0.1％人血清白蛋白或牛血清白蛋白的载体蛋白，并按工作用量分装后冻存在−20 °C。

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
0000191298
0000175443
0000157673
0000157673
0000156160

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Oxytocin antagonists are synthetic analogues that have the nonapeptide structure of oxytocin. They act by competing with oxytocin for receptors in the myometrium. Animal experiments and pilot clinical studies have examined several agents and, of these, atosiban has been the
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