生物来源
goat
偶联物
unconjugated
抗体形式
whole antiserum
抗体产品类型
primary antibodies
克隆
polyclonal
分子量
antigen 40.8 kDa (sedimentation velocity and diffusion studies)
包含
15 mM sodium azide
种属反应性
human
技术
quantitative precipitin assay: 1.5 mg/mL
UniProt登记号
运输
dry ice
储存温度
−20°C
靶向翻译后修饰
unmodified
基因信息
human ... ORM1(5004)
一般描述
α-1 acid glycoprotein is a protein at 43kDa secreted mainly from the liver during acute phase reaction. Its expression is induced by cytokines and corticosteroids.
Alpha-1-acid glycoprotein (AGP) is also known as orosomucoid (ORM). It is a 41-43 kDa glycoprotein. It is one of the important acute phase proteins found in humans, rats, mice and other species. This immunosuppressive glycoprotein is composed of two isoforms, such as ORM1 and ORM2.
Goat Anti-α1-Acid Glycoprotein antibody is immunospecific for human α1-acid glycoprotein by immunoelectrophoresis versus human serum and α1-acid glycoprotein.
免疫原
purified human α1-acid glycoprotein
应用
Goat Anti-α1-Acid Glycoprotein antibody can be used for quantitative precipitin assays at 1.5mg/ml.
生化/生理作用
Abberations of orosomucoid 1 (ORM1) is linked with the pharmacokinetics of telmisartan. This plasma protein participates in the binding and transport of several drugs.
外形
Supplied as a liquid containing 15mM sodium azide as preservative.
免责声明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Effect of alpha-1-acid glycoprotein binding on pharmacokinetics and pharmacodynamics
Huang Z, et al.
Current Drug Metabolism, 14(2), 226-238 (2013)
Polymorphism of ORM1 Is Associated with the Pharmacokinetics of Telmisartan
Chen WQ, et al.
Testing, 8(8) (2013)
Alpha-1-acid glycoprotein
Fournier T, et al.
Biochimica et Biophysica Acta, 1482(1-2), 157-171 (2000)
Elisabetta Razzuoli et al.
Veterinary research communications, 47(3), 1615-1627 (2023-04-11)
Canine Soft Tissue Sarcoma (STS) cell line A-72 has been largely employed for antiviral and antiproliferative studies. However, there are few information on their characteristics. Our aim was to evaluate A-72 expression level of genes and proteins involved in the
Kiwamu Nakamura et al.
Cytokine, 73(1), 8-15 (2015-02-18)
Orosomucoid (ORM, composed of two isoforms, ORM1 and ORM2) has been described as an inducer of M2 macrophages, which are cells that decrease host antibacterial innate immunities. However, it is unknown which phenotypes of M2 macrophages are induced by ORM.
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