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A3221

Sigma-Aldrich

碘乙酰胺

Single use vial of 56 mg

别名:

IAA

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10 VIALS
¥1,298.62

¥1,298.62

国内现货，预计发货时间2025年4月11日详情

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10 VIALS
¥1,298.62

About This Item

线性分子式:
ICH2CONH2
CAS号:
144-48-9
分子量:
184.96
Beilstein:
1739080
EC 号:
205-630-1
MDL编号:
MFCD00008028
UNSPSC代码:
12352111
PubChem化学物质编号:
24890731
NACRES:
NA.56

¥1,298.62

国内现货，预计发货时间2025年4月11日详情

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生物来源

synthetic (organic)

方案

≥99% (HPLC)

表单

powder

包装

vial of 56 mg (Single use)

储存条件

(Tightly closed. Dry. Keep in a well-ventilated place. Keep locked up or in an area accessible
only to qualified or authorized persons.)

颜色

white to off-white

mp

92-95 °C (lit.)

溶解性

H2O: soluble 50 mg/mL, clear, colorless to faintly yellow

适用性

suitable for LC-MS

应用

microbiology

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407710I1149I6125
碘乙酰胺 Single use vial of 56 mg

A3221

碘乙酰胺

α-碘乙酰胺 α-Iodoacetamide, CAS 144-48-9, is an irreversible inhibitor of several cysteine proteases.

407710

α-碘乙酰胺

碘乙酰胺 BioUltra

I1149

碘乙酰胺

碘乙酰胺 ≥99% (NMR), crystalline

I6125

碘乙酰胺

biological source

synthetic (organic)

biological source

-

biological source

synthetic (organic)

biological source

synthetic (organic)

Quality Level

200

Quality Level

200

Quality Level

300

Quality Level

300

form

powder

form

crystalline solid

form

powder

form

crystalline

storage temp.

2-8°C

storage temp.

−20°C

storage temp.

2-8°C

storage temp.

2-8°C

solubility

H2O: soluble 50 mg/mL, clear, colorless to faintly yellow

solubility

methanol: 1:20, DMF: soluble, ethanol: soluble, water: soluble

solubility

H2O: 0.5 M, clear, colorless

solubility

H2O: soluble 0.5 M, clear, colorless

一般描述

2-碘乙酰胺是一种巯基-烷基化试剂，常用于生物化学、细胞培养和蛋白质组学研究中的肽图分析。作用方式与碘乙酸类似，主要通过共价结合蛋白质半胱氨酸残基上的巯基，防止二硫键形成。它在多种应用中发挥重要作用，比如在蛋白质二维电泳中，可作为去泛素化酶(DUB)抑制剂和肽酶抑制剂，减少拖尾并提高分辨率。也常用于肽质谱法从头测序中的样品制备。

它会与蛋白质中的半胱氨酸和组氨酸残基发生特定的相互作用，影响各种酶（如，核糖核酸酶）。与组氨酸缓慢反应的抑制特性令其适合蛋白酶研究（如，半胱氨酸蛋白酶）。碘乙酰胺的优势在于不可逆地抑制酶，形成稳定的蛋白衍生物，是蛋白质结构、蛋白行为和酶抑制研究的有用工具。

应用

碘乙酰胺已用于：
  • 防止蛋白质样品发生酶促二硫键还原反应[1]
  • 在细胞生物学研究中抑制甘油醛-3-磷酸脱氢酶，有效阻断ATP生产[1]

生化/生理作用

碘乙酰胺在肽测序中胱氨酸残基的烷基化试剂。它是活性位点上含有胱氨酸的酶的的一种不可逆抑制剂。它与组氨酸残基的反应速度要慢得多，但这种活性是核糖核酸酶抑制的原因。

特点和优势

高品质化合物，适于多个研究领域

包装

密封安瓿包装

其他说明

如需了解生化试剂系列的更多信息，请填写此表。

法律信息

与蛋白质组系统合作开发的技术™
Proteome Systems is a trademark of Proteome Systems Ltd

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象形图

Skull and crossbonesHealth hazard
GHS06,GHS08

警示用语：

Danger

危险分类

Acute Tox. 3 Oral - Aquatic Chronic 4 - Resp. Sens. 1 - Skin Sens. 1

储存分类代码

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges

  • 技术规格说明书

    • 历史批次信息供参考:

    分析证书(COA)

    Lot/Batch Number
    0000412963
    0000412963
    0000411961
    0000411961
    0000360635

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    在文件库中查找您最近购买产品的文档。

    访问文档库

    Kristen L Koterba et al.
    Journal of biotechnology, 157(1), 261-267 (2011-12-06)
    During large-scale manufacturing of an IgG1 monoclonal antibody in Chinese hamster ovary (CHO) cells, reduction of the antibody's disulfide bonds was observed. We present evidence that mammalian thioredoxin 1 (TXN1) is the terminal enzyme responsible for this reduction event. We
    Tanja Scherrer et al.
    Genome biology, 12(1), R3-R3 (2011-01-15)
    Glucose inhibition of gluconeogenic growth suppressor 2 protein (Gis2p) and zinc-finger protein 9 (ZNF9) are conserved yeast and human zinc-finger proteins. The function of yeast Gis2p is unknown, but human ZNF9 has been reported to bind nucleic acids, and mutations
    Mirko Zaffagnini et al.
    Antioxidants & redox signaling, 16(1), 17-32 (2011-06-29)
    Cysteines (Cys) made acidic by the protein environment are generally sensitive to pro-oxidant molecules. Glutathionylation is a post-translational modification that can occur by spontaneous reaction of reduced glutathione (GSH) with oxidized Cys as sulfenic acids (-SOH). The reverse reaction (deglutathionylation)
    Valentina R Minciacchi et al.
    Oncotarget, 6(13), 11327-11341 (2015-04-11)
    Large oncosomes (LO) are atypically large (1-10 µm diameter) cancer-derived extracellular vesicles (EVs), originating from the shedding of membrane blebs and associated with advanced disease. We report that 25% of the proteins, identified by a quantitative proteomics analysis, are differentially
    Elena B Lugli et al.
    Arthritis research & therapy, 17, 9-9 (2015-01-21)
    Smoking is a well-established risk factor for rheumatoid arthritis (RA), and it has been proposed that smoking-induced citrullination renders autoantigens immunogenic. To investigate this mechanism, we examined human lung tissue from 40 subjects with defined smoking status, with or without
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