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类型
Grade I
质量水平
表单
lyophilized powder
比活
≥1500 units/mg protein
组成
Protein, ≥60%
UniProt登记号
储存温度
−20°C
基因信息
pig ... ACY1(396930)
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应用
猪肾中的酰化酶 I 已被用于研究各种 S-烷基-N-乙酰基-L-半胱氨酸及其碳、氧类似物的酰化酶 I 催化的脱乙酰作用 。酰化酶 I 可能有助于催化 N-乙酰氨基酸生成对映体纯的 L-氨基酸 。
生化/生理作用
酰化酶 I 催化 N-乙酰基-L-半胱氨酸和 S-烷基-N-乙酰基-L-半胱氨酸的脱乙酰化。正丁基丙二酸是酰化酶 Ⅰ 的抑制剂。S-烷基-N-乙酰基-L-半胱氨酸与短 (C0-C3) 和不分枝 S-烷基取代已被发现是良好的酰化酶 I 底物。
单位定义
一个单元将在pH 7.0 和 25°C 条件下每小时水解 1.0μmol N-乙酰- L -蛋氨酸。
分析说明
缩二脲法测定蛋白
警示用语：
Danger
危险分类
Eye Irrit. 2 - Resp. Sens. 1 - Skin Irrit. 2 - STOT SE 3
靶器官
Respiratory system
储存分类代码
11 - Combustible Solids
WGK
WGK 1
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, type N95 (US)
法规信息
动植物源性产品
历史批次信息供参考:
分析证书(COA)
Lot/Batch Number
Debby Ngo et al.
JCI insight, 6(5) (2021-02-17)
Recent advances in proteomic technologies have made high-throughput profiling of low-abundance proteins in large epidemiological cohorts increasingly feasible. We investigated whether aptamer-based proteomic profiling could identify biomarkers associated with future development of type 2 diabetes (T2DM) beyond known risk factors.
Jinit Masania et al.
Oxidative medicine and cellular longevity, 2019, 4851323-4851323 (2019-12-13)
Glycation, oxidation, nitration, and crosslinking of proteins are implicated in the pathogenic mechanisms of type 2 diabetes, cardiovascular disease, and chronic kidney disease. Related modified amino acids formed by proteolysis are excreted in urine. We quantified urinary levels of these
K Kubo et al.
The Journal of antibiotics, 33(6), 556-565 (1980-06-01)
L-Amino acid acylase and D-amino acid acylase were stable below 50 degrees C, although the D-enzyme was more thermostable than the L-enzyme at higher temperatures. At 30 degrees C they showed the highest reaction velocity in phosphate buffer of pH
Y Fukagawa et al.
The Journal of antibiotics, 33(6), 543-549 (1980-06-01)
PS-5 was deacetylated to NS-5 (deacetylated PS-5) by l-amino acid acylase from porcine kidney and D-amino acid acylase from Streptomyces olivaceus but not by l-amino acid acylase from Aspergillus sp. Using PS-5, N-chloroacetyl-l-phenylalanine and N-chloroacetyl-D-valine as substrates, acylase producers were
Safiye Selen Özcan et al.
Journal of industrial microbiology & biotechnology, 46(8), 1103-1111 (2019-04-26)
Microbial contamination in metalworking systems is a critical problem. This study determined the microbial communities in metalworking fluids (MWFs) from two machining shops and investigated the effect of quorum sensing inhibition (QSI) on biofilm growth. In both operations, biofilm-associated and
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