推荐产品
生物来源
mouse
偶联物
unconjugated
抗体形式
ascites fluid
抗体产品类型
primary antibodies
克隆
M8-P1-A3, monoclonal
分子量
antigen ~110 kDa
种属反应性
sheep, canine, rat, pig
请勿与下列物质发生反应
chicken, Xenopus
技术
immunohistochemistry (frozen sections): 1:100
western blot: 1:250
同位素/亚型
IgG1
UniProt登记号
运输
dry ice
储存温度
−20°C
基因信息
rat ... Atp1a1(24211)
一般描述
Epitope mapping studies indicates the epitope is between amino acids 496 and 506 of lamb kidney Na+/K+ ATPase. No reactivity is observed in chicken or Xenopus. Staining is consistent with the plasma membrane localization of Na+/K+ ATPase.
Mouse monoclonal anti-Na+/K+ ATPase (α1 subunit) reacts with the α1 subunit of Na+/K+-ATPase in sheep, canine, rat and pig. In rat, the antibody shows no reactivity with the α2 or α3 subunits.
Na+/K+ transporting ATPase subunit α 1 is an ion transport pump critical for maintaining the gradient of Na and K ions across the plasma membrane.
免疫原
lamb kidney α1 subunit of Na+/K+ ATPase.
应用
Mouse monoclonal anti-Na+/K+ ATPase (α1 subunit) has been used for western blot and co-immunoprecipitation assays. The product can also be used for immunohistochemistry applications using frozen sections at a dilution of 1:100.
外形
Solution in phosphate buffered saline containing 0.05% sodium azide.
免责声明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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储存分类代码
10 - Combustible liquids
WGK
WGK 1
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)
法规信息
新产品
The Journal of biological chemistry, 277(23), 20270-20276 (2002-04-04)
The two variants of the gamma subunit of the rat renal sodium pump, gamma(a) and gamma(b), have similar effects on the Na,K-ATPase. Both increase the affinity for ATP due to a shift in the enzyme's E(1) <--> E(2) conformational equilibrium
Biochimica et biophysica acta, 1864(7), 2458-2471 (2018-04-15)
α-Tocopherol (α-Toc) overload increases the risk of dying in humans (E.R. Miller III et al. Meta-analysis: high-dosage vitamin E supplementation may increase all-cause mortality Ann Int Med. 142 (2005) 37-46), and overload during early development leads to elevation of blood
Journal of molecular histology, 51(6), 701-716 (2020-10-19)
The kidney controls body fluids, electrolyte and acid-base balance. Previously, we demonstrated that hyperpolarization-activated and cyclic nucleotide-gated (HCN) cation channels participate in ammonium excretion in the rat kidney. Since acid-base balance is closely linked to potassium metabolism, in the present
American journal of physiology. Renal physiology, 297(5), F1324-F1329 (2009-09-04)
To understand how rapid changes in blood pressure can regulate Na-K-ATPase in the kidney cortex, we tested the hypothesis that a short-term (5 min) decrease in renal perfusion pressure will increase the amount of Na-K-ATPase in the plasma membranes by
Biochimica et biophysica acta, 719(3), 413-423 (1982-12-17)
Four stable hybridoma cell lines secreting antibodies specific to the membrane (Na+ + K+)-dependent ATPase isolated from lamb kidney medulla have been produced by fusing mouse myeloma cells with spleen cells from immunized mice. These cell lines produce IgG gamma
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