product name
ARL 67156 三钠盐 水合物, ≥98% (HPLC), solid
质量水平
检测方案
≥98% (HPLC)
形式
solid
颜色
white to off-white
溶解性
H2O: >20 mg/mL
DMSO: insoluble
储存温度
−20°C
SMILES字符串
O.[Na+].[Na+].[Na+].CCN(CC)c1ncnc2n(cnc12)[C@@H]3O[C@H](COP(O)(=O)OP([O-])(=O)C(Br)(Br)P([O-])([O-])=O)[C@@H](O)[C@H]3O
InChI
1S/C15H24Br2N5O12P3.3Na.H2O/c1-3-21(4-2)12-9-13(19-6-18-12)22(7-20-9)14-11(24)10(23)8(33-14)5-32-37(30,31)34-36(28,29)15(16,17)35(25,26)27;;;;/h6-8,10-11,14,23-24H,3-5H2,1-2H3,(H,28,29)(H,30,31)(H2,25,26,27);;;;1H2/q;3*+1;/p-3/t8-,10-,11-,14-;;;;/m1..../s1
InChI key
UWMONIJVKGTUGE-OPKBHZIBSA-K
基因信息
human ... ENTPD2(954)
一般描述
ARL 67156，一种核苷酸/ATP类似物，CD39的竞争性抑制剂。这种胞外ATP酶抑制剂含有β,γ-二溴亚甲基桥，推测其在生物学研究中具有代谢稳定性。
ARL-67156优先抑制鼠结肠中ADP 的分解，而不是抑制ATP的分解。它常被用于抑制组织制备液中的ATP水解。
应用
ARL 67156三钠盐水合物可用于：
- 在脑脊液提取时抑制ATP降解
- 在细胞质和线粒体ATP定量实验中，作为ATP酶抑制剂防止ATP降解
- 在ATP释放试验中，作为胞外ATP酶抑制剂处理癌细胞
生化/生理作用
胞外ATPase抑制剂；防止2嘌呤受体激动剂的代谢。
WGK
WGK 3
B E Crack et al.
British journal of pharmacology, 114(2), 475-481 (1995-01-01)
1. FPL 67156 (6-N,N-diethyl-beta, gamma-dibromomethylene-D-ATP), is a newly synthesized analogue of ATP. 2. In a rabbit isolated tracheal epithelium preparation, measuring P2U-purinoceptor-dependent chloride secretion, FPL 67156 was discovered to potentiate the responses to UTP but not those to ATP-gamma-S. UTP
Charlie H T Kwok et al.
Frontiers in immunology, 12, 626884-626884 (2021-04-27)
Increased afferent input resulting from painful injury augments the activity of central nociceptive circuits via both neuron-neuron and neuron-glia interactions. Microglia, resident immune cells of the central nervous system (CNS), play a crucial role in the pathogenesis of chronic pain.
T D Westfall et al.
European journal of pharmacology, 329(2-3), 169-173 (1997-06-25)
The influence of enzymatic degradation on the neurotransmitter actions of ATP was studied using the ecto-ATPase inhibitor 6-N,N-diethyl-D-beta,gamma-dibromomethyleneATP (ARL 67156). Field stimulation of the parasympathetic nerves innervating guinea-pig urinary bladder muscle strips (1-8 Hz for 20 s) produced characteristic biphasic
T D Westfall et al.
British journal of pharmacology, 117(5), 867-872 (1996-03-01)
1. Field stimulation of the sympathetic nerves of the guinea-pig isolated vas deferens with trains of pulses of 20 s at 1-8 Hz produced characteristic biphasic contractions. The effect of the novel ecto-ATPase inhibitor, 6-N,N-diethyl-D-beta, gamma-dibromomethyleneATP (ARL 67156, formerly known
S A Lévesque et al.
British journal of pharmacology, 152(1), 141-150 (2007-07-03)
ARL 67156, 6-N,N-Diethyl-D-beta-gamma-dibromomethylene adenosine triphosphate, originally named FPL 67156, is the only commercially available inhibitor of ecto-ATPases. Since the first report on this molecule, various ectonucleotidases responsible for the hydrolysis of ATP at the cell surface have been cloned and
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