推荐产品
生物来源
Centella asiatica
质量水平
方案
≥98% (HPLC)
表单
powder
储存条件
protect from light
颜色
white
mp
325-330 °C (lit.)
溶解性
methanol: 1 mg/mL, clear, colorless
应用
metabolomics
vitamins, nutraceuticals, and natural products
储存温度
2-8°C
SMILES字符串
C[C@@H]1CC[C@@]2(CC[C@]3(C)C(=CC[C@@H]4[C@@]5(C)C[C@@H](O)[C@H](O)[C@@](C)(CO)[C@@H]5CC[C@@]34C)[C@@H]2[C@H]1C)C(O)=O
InChI
1S/C30H48O5/c1-17-9-12-30(25(34)35)14-13-28(5)19(23(30)18(17)2)7-8-22-26(3)15-20(32)24(33)27(4,16-31)21(26)10-11-29(22,28)6/h7,17-18,20-24,31-33H,8-16H2,1-6H3,(H,34,35)/t17-,18+,20-,21-,22-,23+,24+,26+,27+,28-,29-,30+/m1/s1
InChI key
JXSVIVRDWWRQRT-UYDOISQJSA-N
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一般描述
积雪草酸是一种天然存在的五环三萜，来源于积雪草。
应用
积雪草酸已被用于考察其在胶质母细胞瘤细胞中细胞毒性潜力的 体外研究。 它也被用于积雪草中积雪草酸的体外定量分析以及以有机刺激剂增加积雪草酸产量的 体外研究。
积雪草酸衍生物合成的起始物料：
- 抗癌药
- 糖原磷酸化酶抑制剂
- 肝保护剂
生化/生理作用
据报道积雪草酸对胶质母细胞瘤、乳腺、肝脏、黑素瘤和结肠癌有毒害作用，并具有抗血管生成活性。此外，它可穿过血脑屏障，并导致人恶性胶质瘤和肝细胞瘤的细胞凋亡。积雪草酸也有效抑制紫外线A调节的信号转导通路，因此可用于防止紫外线A诱导的皮肤光老化。它具有抗伤痛和抗炎特性，对于β-淀粉样蛋白和谷氨酸酯诱导的神经毒性有抑制作用。
积雪草酸常用于伤口愈合。积雪草酸具有抗氧化、抗炎和神经保护属性
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
历史批次信息供参考:
分析证书(COA)
Lot/Batch Number
Quantification of asiatic acid from plant parts of Centella asiatica L. and enhancement of its synthesis through organic elicitors in in vitro
Mohammadparast B, et al.,
Horticulture, Environment, and Biotechnology, 55(6), 578-582 (2014)
Byung Chul Park et al.
Cancer letters, 218(1), 81-90 (2005-01-11)
Asiatic acid (AA) is a pentacyclic triterpene found in Centella asiatica. In the present study, the mechanism of anticancer effect of AA on skin cancer was investigated. AA decreased viability and induced apoptosis in human melanoma SK-MEL-2 cells in a
Sreenath Nandakumar Nair et al.
Rapid communications in mass spectrometry : RCM, 26(17), 1899-1908 (2012-08-01)
Asiatic acid (AA), a pentacyclic triterpene from Centella asiatica (L.) Urban, has shown numerous therapeutic activities. However, none of the published works to date has used high-performance liquid chromatography/tandem mass spectrometry (HPLC/MS/MS) for determination of AA from biological fluids. Therefore
Shyh-Shyun Huang et al.
Evidence-based complementary and alternative medicine : eCAM, 2011, 895857-895857 (2011-05-18)
Asiatic acid (AA), a pentacyclic triterpene compound in the medicinal plant Centella asiatica, was evaluated for antinociceptive and anti-inflammatory effects. Treatment of male ICR mice with AA significantly inhibited the numbers of acetic acid-induced writhing responses and the formalin-induced pain
Vinayagam Ramachandran et al.
Phytomedicine : international journal of phytotherapy and phytopharmacology, 20(3-4), 230-236 (2012-10-30)
Asiatic acid (AA), a triterpenoid derivative of Centella asiatica, has shown significant biological effects of antioxidant and anti-inflammatory activities. Aim of this investigation was to evaluate the antihyperglycemic effect of AA on the activities of hepatic enzymes of carbohydrate metabolism
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