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Merck
CN

A2612

Sigma-Aldrich

亚细亚酸

≥98% (HPLC), from Centella asiatica

别名:

2α, 23-二羟基熊果酸, NSC 166063, 达玛醇酸

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About This Item

经验公式(希尔记法):
C30H48O5
CAS号:
分子量:
488.70
EC 号:
MDL编号:
UNSPSC代码:
12352212
PubChem化学物质编号:
NACRES:
NA.25

生物来源

Centella asiatica

质量水平

方案

≥98% (HPLC)

表单

powder

储存条件

protect from light

颜色

white

mp

325-330 °C (lit.)

溶解性

methanol: 1 mg/mL, clear, colorless

应用

metabolomics
vitamins, nutraceuticals, and natural products

储存温度

2-8°C

SMILES字符串

C[C@@H]1CC[C@@]2(CC[C@]3(C)C(=CC[C@@H]4[C@@]5(C)C[C@@H](O)[C@H](O)[C@@](C)(CO)[C@@H]5CC[C@@]34C)[C@@H]2[C@H]1C)C(O)=O

InChI

1S/C30H48O5/c1-17-9-12-30(25(34)35)14-13-28(5)19(23(30)18(17)2)7-8-22-26(3)15-20(32)24(33)27(4,16-31)21(26)10-11-29(22,28)6/h7,17-18,20-24,31-33H,8-16H2,1-6H3,(H,34,35)/t17-,18+,20-,21-,22-,23+,24+,26+,27+,28-,29-,30+/m1/s1

InChI key

JXSVIVRDWWRQRT-UYDOISQJSA-N

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一般描述

积雪草酸是一种天然存在的五环三萜,来源于积雪草

应用

积雪草酸已被用于考察其在胶质母细胞瘤细胞中细胞毒性潜力的 体外研究。 它也被用于积雪草中积雪草酸的体外定量分析以及以有机刺激剂增加积雪草酸产量的 体外研究。
积雪草酸衍生物合成的起始物料:
  • 抗癌药
  • 糖原磷酸化酶抑制剂
  • 肝保护剂

生化/生理作用

据报道积雪草酸对胶质母细胞瘤、乳腺、肝脏、黑素瘤和结肠癌有毒害作用,并具有抗血管生成活性。此外,它可穿过血脑屏障,并导致人恶性胶质瘤和肝细胞瘤的细胞凋亡。积雪草酸也有效抑制紫外线A调节的信号转导通路,因此可用于防止紫外线A诱导的皮肤光老化。它具有抗伤痛和抗炎特性,对于β-淀粉样蛋白和谷氨酸酯诱导的神经毒性有抑制作用。
积雪草酸常用于伤口愈合。积雪草酸具有抗氧化、抗炎和神经保护属性

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable


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分析证书(COA)

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Byung Chul Park et al.
Cancer letters, 218(1), 81-90 (2005-01-11)
Asiatic acid (AA) is a pentacyclic triterpene found in Centella asiatica. In the present study, the mechanism of anticancer effect of AA on skin cancer was investigated. AA decreased viability and induced apoptosis in human melanoma SK-MEL-2 cells in a
Quantification of asiatic acid from plant parts of Centella asiatica L. and enhancement of its synthesis through organic elicitors in in vitro
Mohammadparast B, et al.,
Horticulture, Environment, and Biotechnology, 55(6), 578-582 (2014)
Yong Soo Lee et al.
European journal of pharmacology, 476(3), 173-178 (2003-09-13)
Premature aging of the skin (photoaging) is a well-documented consequence of exposure to ultraviolet-A (UVA). Enhanced generation of reactive oxygen species and induction of matrix metalloproteinases (MMPs) appear to be the most important components of UVA-modulated signal transduction pathways, ultimately
Flourina Kumar Thakor et al.
Molecular and cellular biochemistry, 430(1-2), 179-190 (2017-02-17)
Glioblastoma multiforme is the most common and malignant primary brain tumor in adults. Despite current treatment options including surgery followed by radiation and chemotherapy with temozolomide and cisplatin, the median survival rate remains low (<16 months). Combined with increasing drug
Sreenath Nandakumar Nair et al.
Rapid communications in mass spectrometry : RCM, 26(17), 1899-1908 (2012-08-01)
Asiatic acid (AA), a pentacyclic triterpene from Centella asiatica (L.) Urban, has shown numerous therapeutic activities. However, none of the published works to date has used high-performance liquid chromatography/tandem mass spectrometry (HPLC/MS/MS) for determination of AA from biological fluids. Therefore

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