A255
A-77636 hydrochloride hydrate
≥98% (HPLC), solid
别名:
(−)-(1R,3S)-3-Adamantyl-1-(aminomethyl)-3,4-dihydro-5,6-dihydroxy-1H-2-benzopyran hydrochloride hydrate
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所有图片(1)
About This Item
经验公式（希尔记法）:
C20H27NO3 · HCl · xH2O
CAS号:
分子量:
365.89 (anhydrous basis)
UNSPSC代码:
12352200
PubChem化学物质编号:
NACRES:
NA.77
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质量水平
方案
≥98% (HPLC)
表单
solid
储存条件
desiccated
protect from light
颜色
white to off-white
溶解性
H2O: >10 mg/mL
储存温度
−20°C
SMILES字符串
O.Cl.NC[C@@H]1O[C@@H](Cc2c(O)c(O)ccc12)C34CC5CC(CC(C5)C3)C4
InChI
1S/C20H27NO3.ClH.H2O/c21-10-17-14-1-2-16(22)19(23)15(14)6-18(24-17)20-7-11-3-12(8-20)5-13(4-11)9-20;;/h1-2,11-13,17-18,22-23H,3-10,21H2;1H;1H2/t11?,12?,13?,17-,18-,20?;;/m0../s1
InChI key
KNACNUUSUYTFDY-LIWDBWMRSA-N
基因信息
human ... DRD1(1812)
生化/生理作用
Potent, orally active D1 dopamine receptor agonist.
特点和优势
This compound is featured on the Dopamine Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
注意
Hygroscopic, photosensitive, and oxygen-sensitive. Solutions should be freshly prepared.
法律信息
Manufactured and sold under exclusive license from Abbott Laboratories.
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, type N95 (US)
法规信息
新产品
从最新的版本中选择一种：
分析证书(COA)
Lot/Batch Number
Sanjida S Saklayen et al.
The Journal of pharmacology and experimental therapeutics, 311(1), 342-348 (2004-06-04)
The nigrostriatal dopamine system of the mammalian brain is necessary for normal voluntary motor activity. Dopamine exerts its effects by acting on two primary receptor subtypes: D1-like (D1 and D5) and D2-like (D2, D3, and D4) receptors. Previous research has
Vera Bubenikova-Valesova et al.
The international journal of neuropsychopharmacology, 12(7), 873-883 (2009-01-22)
Cognitive impairment has been found across all subtypes of schizophrenia. The location and function of dopamine-1 receptors (D1Rs) make them attractive targets for the treatment of cognitive impairment in schizophrenia. Here we investigate the systemic effect of a D1R agonist
S Ofori et al.
General pharmacology, 26(1), 51-57 (1995-01-01)
1. Homogenates of bovine retinas were used to study the capacities of two new dopamine (DA) receptor agonists, e.g. YM 435 and A 77636, to interact with D1 receptors. 2. Adenylate cyclase experiments. YM 435 and A 77636 enhanced cAMP
Amy F T Arnsten et al.
Biological psychiatry, 57(11), 1377-1384 (2005-06-14)
The prefrontal cortex guides behaviors, thoughts, and feelings using representational knowledge, i.e., working memory. These fundamental cognitive abilities subserve the so-called executive functions: the ability to inhibit inappropriate behaviors and thoughts, regulate our attention, monitor our actions, and plan and
Allison L Chausmer et al.
Psychopharmacology, 159(2), 145-153 (2002-02-28)
Recent data suggest that dopamine (DA) D1-like receptor full agonists may be potential pharmacotherapeutic agents for treating cocaine abuse. The structurally novel isochroman D1-like agonist, A-77636, has not been well characterized and may prove to be useful as such an
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