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Merck
CN

A2478

Sigma-Aldrich

APHA Compound 8

solid, ≥98% (HPLC)

别名:

3-(1-Methyl-4-phenylacetyl-1H-2-pyrrolyl)-N-hydroxy-2-propenamide

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About This Item

经验公式(希尔记法):
C16H16N2O3
分子量:
284.31
MDL编号:
UNSPSC代码:
12352202
PubChem化学物质编号:
NACRES:
NA.77

产品名称

APHA Compound 8, ≥98% (HPLC), solid

质量水平

方案

≥98% (HPLC)

表单

solid

溶解性

DMSO: >10 mg/mL
H2O: insoluble

储存温度

2-8°C

SMILES字符串

Cn1cc(cc1\C=C\C(=O)NO)C(=O)Cc2ccccc2

InChI

1S/C16H16N2O3/c1-18-11-13(10-14(18)7-8-16(20)17-21)15(19)9-12-5-3-2-4-6-12/h2-8,10-11,21H,9H2,1H3,(H,17,20)/b8-7+

InChI key

UFQOXIMRSMFQRI-BQYQJAHWSA-N

生化/生理作用

HDAC (histone deacetylase) inhibitor.
One of a class of aroyl pyrrole hydroxy amide (APHA) compounds showing histone deacetylase (HDAC) inhibition, Compound 8 is the most potent and HDAC class I-selective.

象形图

CorrosionExclamation mark

警示用语:

Danger

危险声明

危险分类

Acute Tox. 4 Oral - Eye Dam. 1 - Skin Sens. 1

储存分类代码

11 - Combustible Solids

WGK

WGK 2

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

dust mask type N95 (US), Eyeshields, Faceshields, Gloves


历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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Seiji Kuroda et al.
Molecular therapy. Methods & clinical development, 17, 612-621 (2020-04-18)
Non-toxic herpes simplex virus (HSV) vectors can be generated by functional deletion of all immediate-early (IE) genes, providing a benign vehicle with potential for gene therapy. However, deletion of multiple IE genes raises manufacturing concerns and thus limits clinical application

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