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Merck
CN
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文件

A2408

Sigma-Aldrich

S-(5′-腺苷)-L-甲硫氨酸 对甲苯磺酸盐

≥80% (HPLC), ≥80% (spectrophotometric assay)

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别名:
AdoMet, SAM 对甲苯磺酸盐
经验公式（希尔记法）:
C15H23N6O5S · C7H7O3S · xC7H8O3S
CAS号:
52248-03-0
分子量:
570.64 (free base basis)
UNSPSC代码:
12352209
PubChem化学物质编号:
24890653
NACRES:
NA.32

生物来源

synthetic (Organic)

质量水平

300

检测方案

≥80% (HPLC)
≥80% (spectrophotometric assay)

形式

powder

组成

p-Toluenesulfonate content, 1.6-4.4 mol/mol

颜色

white to off-white

溶解性

H2O: 100 mg/mL

运输

dry ice

储存温度

−20°C

SMILES字符串

O=C(O[H])[C@](N([H])[H])([H])C([H])([H])C([H])([H])[S@+](C([H])([H])[H])C([H])([H])[C@@]([C@](O[H])([H])[C@@]1([H])O[H])([H])O[C@]1([H])N2C3=C(N=C2[H])C(N([H])[H])=NC([H])=N3.O=S(C4=C([H])C([H])=C(C([H])([H])[H])C([H])=C4[H])([O-])=O

InChI

1S/C15H22N6O5S.C7H8O3S/c1-27(3-2-7(16)15(24)25)4-8-10(22)11(23)14(26-8)21-6-20-9-12(17)18-5-19-13(9)21;1-6-2-4-7(5-3-6)11(8,9)10/h5-8,10-11,14,22-23H,2-4,16H2,1H3,(H2-,17,18,19,24,25);2-5H,1H3,(H,8,9,10)/t7-,8+,10+,11+,14+,27?;/m0./s1

InChI key

VHPOFDUCFKOUHV-XKGORWRGSA-N

相关类别

一般描述

S-(5′-腺苷)-L-甲硫氨酸-对甲苯磺酸盐用于治疗抑郁症、肝硬化、胆汁淤积症和退行性关节病变。

应用

S-(5′-腺苷)-L-甲硫氨酸-对甲苯磺酸盐已用于细胞增殖检测。它也用于甲基化检测。

生化/生理作用

甲基供体；酶催化甲基化的辅因子，包括儿茶酚O-甲基转移酶（COMT）和DNA甲基转移酶（DNMT）。 虽然所有细胞中都存在，但在85％甲基化反应发生的肝脏中富集。 它还参与调控肝功能、生长和损伤反应。
S-(5′-腺苷)-L-甲硫氨酸（SAM）在正常肝细胞和正常结肠上皮细胞中抗凋亡，但在人肝细胞癌（HCC）HepG2细胞和结肠癌细胞中促凋亡。

注意

该材料在室温下不稳定。

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

Eyeshields, Gloves, type N95 (US)

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