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A231

花生四烯基三氟甲基酮

Name: 花生四烯基三氟甲基酮
Brand: SIGMA

oil, ≥97% (NMR)

别名:

1,1,1-三氟甲基-6,9,12,15-heieicosatetraen-2-酮, AACOCF₃, Arach-CF₃

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关于此项目

经验公式（希尔记法）:

C₂₁H₃₁F₃O

化学文摘社编号:

149301-79-1

分子量:

356.47

NACRES:

NA.77

PubChem Substance ID:

24890647

UNSPSC Code:

51111800

MDL number:

MFCD00236427

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属性

Quality Level

100

assay

≥97% (NMR)

form

oil

storage condition

desiccated, protect from light, under inert gas

color

yellow

solubility

DMSO: >5 mg/mL

storage temp.

−20°C

SMILES string

CCCCC\C=C/C\C=C/C\C=C/C\C=C/CCCC(=O)C(F)(F)F

InChI

1S/C21H31F3O/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20(25)21(22,23)24/h6-7,9-10,12-13,15-16H,2-5,8,11,14,17-19H2,1H3/b7-6-,10-9-,13-12-,16-15-

InChI key

PLWROONZUDKYKG-DOFZRALJSA-N

Gene Information

human ... PLA2G1B(5319)

说明

Application

花生四烯酸三氟甲基酮（AACOCF3）已被用作阿那达胺降解抑制剂，以研究其在原代星形胶质细胞培养物中的作用。

Biochem/physiol Actions

花生四烯酸三氟甲基酮（AACOCF3）在抑制血小板产生的12-羟基二十碳四烯酸（12-HETE）和血栓烷B2中起作用。

体外抑制大麻素水解；抑制磷脂酶A₂。

Features and Benefits

该化合物在受体分类和信号转导手册的磷脂酶A2 页面上有重点介绍。想要浏览手册的其他页面，请单击此处。

Disclaimer

吸湿性、光敏性、空气敏感性

存储类别

10 - Combustible liquids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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Arachidonyl trifluoromethyl ketone ameliorates experimental autoimmune encephalomyelitis via blocking peroxynitrite formation in mouse spinal cord white matter.

Adam C Vana et al.

Experimental neurology, 231(1), 45-55 (2011-06-21)

Inhibition of phospholipase A(2) (PLA(2)) has recently been found to attenuate the pathogenesis of experimental autoimmune encephalomyelitis (EAE), a commonly used animal model of multiple sclerosis (MS). However, the protective mechanisms that underlie PLA(2) inhibition are still not well understood.

Altered spinal arachidonic acid turnover after peripheral nerve injury regulates regional glutamate concentration and neuropathic pain behaviors in rats.

Backil Sung et al.

Pain, 131(1-2), 121-131 (2007-02-03)

Spinal glutamate transporters (GT) have been implicated in the mechanisms of neuropathic pain; however, how spinal GT uptake activity is regulated remains unclear. Here we show that alteration of spinal arachidonic acid (AA) turnover after peripheral nerve injury regulated regional

Inhibitors of arachidonoyl ethanolamide hydrolysis.

B Koutek et al.

The Journal of biological chemistry, 269(37), 22937-22940 (1994-09-16)

Arachidonoyl ethanolamide (anandamide) is a naturally occurring brain constituent that binds to a specific brain cannabinoid receptor (CBR1). An amidase activity (anandamide amidase) in membrane fractions of brain and in cultured neuroblastoma cells rapidly degrades anandamide to arachidonic acid (Deutsch

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全球贸易项目编号

货号	GTIN
A231-5MG	04061832555386