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Merck
CN

A231

Sigma-Aldrich

花生四烯基三氟甲基酮

oil, ≥97% (NMR)

别名:

1,1,1-三氟甲基-6,9,12,15-heieicosatetraen-2-酮, AACOCF3, Arach-CF3

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About This Item

经验公式(希尔记法):
C21H31F3O
分子量:
356.47
MDL编号:
UNSPSC代码:
51111800
PubChem化学物质编号:
NACRES:
NA.77

质量水平

方案

≥97% (NMR)

表单

oil

储存条件

desiccated
protect from light
under inert gas

颜色

yellow

溶解性

DMSO: >5 mg/mL

储存温度

−20°C

SMILES字符串

CCCCC\C=C/C\C=C/C\C=C/C\C=C/CCCC(=O)C(F)(F)F

InChI

1S/C21H31F3O/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20(25)21(22,23)24/h6-7,9-10,12-13,15-16H,2-5,8,11,14,17-19H2,1H3/b7-6-,10-9-,13-12-,16-15-

InChI key

PLWROONZUDKYKG-DOFZRALJSA-N

基因信息

human ... PLA2G1B(5319)

应用

花生四烯酸三氟甲基酮(AACOCF3)已被用作阿那达胺降解抑制剂,以研究其在原代星形胶质细胞培养物中的作用。

生化/生理作用

花生四烯酸三氟甲基酮(AACOCF3)在抑制血小板产生的12-羟基二十碳四烯酸(12-HETE)和血栓烷B2中起作用。
体外抑制大麻素水解;抑制磷脂酶A2

特点和优势

该化合物在受体分类和信号转导手册的磷脂酶A2 页面上有重点介绍。想要浏览手册的其他页面, 请单击此处

注意

吸湿性、光敏性、空气敏感性

储存分类代码

10 - Combustible liquids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)


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访问文档库

Wen Li et al.
Biochemistry, 47(52), 13997-14008 (2008-12-10)
TCDD (dioxin) induces a rapid inflammatory response from 3T3-L1 adipocytes as judged by prominent induction of the mRNA expression of prostaglandin-endperoxide synthase 2 (Cox-2) along with other inflammation markers within 1 h. This action of TCDD is clearly antagonized by
Gavin Pharaoh et al.
Scientific reports, 10(1), 13968-13968 (2020-08-20)
Defects in neuromuscular innervation contribute significantly to the age-related decline in muscle mass and function (sarcopenia). Our previous studies demonstrated that denervation induces muscle mitochondrial hydroperoxide production (H2O2 and lipid hydroperoxides (LOOHs)). Here we define the relative contribution of mitochondrial
Arachidonyl trifluoromethyl ketone, a potent inhibitor of 85-kDa phospholipase A2, blocks production of arachidonate and 12-hydroxyeicosatetraenoic acid by calcium ionophore-challenged platelets.
Riendeau D, et al.
The Journal of Biological Chemistry, 269(22), 15619-15624 (1994)
The endogenous cannabinoid anandamide potentiates interleukin-6 production by astrocytes infected with Theiler's murine encephalomyelitis virus by a receptor-mediated pathway
Molina H, et al.
Febs Letters, 433(1-2), 139-142 (1998)
B Koutek et al.
The Journal of biological chemistry, 269(37), 22937-22940 (1994-09-16)
Arachidonoyl ethanolamide (anandamide) is a naturally occurring brain constituent that binds to a specific brain cannabinoid receptor (CBR1). An amidase activity (anandamide amidase) in membrane fractions of brain and in cultured neuroblastoma cells rapidly degrades anandamide to arachidonic acid (Deutsch

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