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Merck
CN
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文件

安全信息

A2275

Sigma-Aldrich

[Sar1, Val5, Ala8]-血管紧张素 II 乙酸盐 水合物

≥97% (HPLC), powder

别名:

沙拉新

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About This Item

经验公式（希尔记法）:
C42H65N13O10 · xC2H4O2 · yH2O
CAS号:
39698-78-7
分子量:
912.05 (anhydrous free base basis)
MDL编号:
MFCD01939339
UNSPSC代码:
12352202
PubChem化学物质编号:
24890641

检测方案

≥97% (HPLC)

形式

powder

储存温度

−20°C

SMILES字符串

O.CC(O)=O.CNCC(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](Cc2c[nH]cn2)C(=O)N3CCC[C@H]3C(=O)N[C@@H](C)C(O)=O

InChI

1S/C42H65N13O10.C2H4O2.H2O/c1-22(2)33(53-35(58)28(50-32(57)20-45-6)9-7-15-47-42(43)44)38(61)51-29(17-25-11-13-27(56)14-12-25)36(59)54-34(23(3)4)39(62)52-30(18-26-19-46-21-48-26)40(63)55-16-8-10-31(55)37(60)49-24(5)41(64)65;1-2(3)4;/h11-14,19,21-24,28-31,33-34,45,56H,7-10,15-18,20H2,1-6H3,(H,46,48)(H,49,60)(H,50,57)(H,51,61)(H,52,62)(H,53,58)(H,54,59)(H,64,65)(H4,43,44,47);1H3,(H,3,4);1H2/t24-,28-,29-,30-,31-,33-,34-;;/m0../s1

InChI key

YBZYNINTWCLDQA-UHKVWXOHSA-N

基因信息

human ... AGTR1(185)
rat ... Agtr1(24180)

Amino Acid Sequence

Sar-Arg-Val-Tyr-Val-His-Pro-Ala

生化/生理作用

竞争性血管紧张素 II 拮抗剂，抑制大鼠体内的血管紧张素 II 的升压效应，降低人体内血压。

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

Eyeshields, Gloves, type N95 (US)

法规信息

监管及禁止进口产品

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L A de Arruda Camargo et al.
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P B Timmermans et al.
Cardiologia (Rome, Italy), 39(12 Suppl 1), 397-400 (1994-12-01)
Angiotensin II (Ang II) is the primary mediator of the renin-angiotensin system (RAS). Inappropriate control of the RAS is critically involved in the development and maintenance of hypertension and congestive heart failure. The actions of Ang II are thought to
Renee C Gaspar et al.
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S Matsubara et al.
Biological & pharmaceutical bulletin, 23(10), 1185-1188 (2000-10-21)
We have characterized angiotensin II (Ang II) receptor subtypes on rat submandibular gland membranes using a radioligand binding assay. [3H]Ang II binding to the membrane fractions exhibited both high (Kd =0.08 nm, Bmax =2.19 fmol/mg protein) and low (Kd =4.19
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