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Merck
CN
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文件

安全信息

A2221

Sigma-Aldrich

抗凝血酶 III 来源于人类血浆

lyophilized powder, ≥95% (SDS-PAGE)

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别名:
因子 Xa 抑制剂, 肝素辅因子
CAS号:
90170-80-2
EC 号:
290-516-4
MDL编号:
MFCD00166632
UNSPSC代码:
12352202
NACRES:
NA.32

生物来源

human plasma

质量水平

200

检测方案

≥95% (SDS-PAGE)

形式

lyophilized powder

UniProt登记号

P01008

储存温度

−20°C

基因信息

human ... SERPINC1(462)

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生化/生理作用

丝氨酸蛋白酶抑制剂；凝血酶和活化因子 X (Xa) 抑制剂。有效浓度与蛋白酶等摩尔。

联系

不要与凝血酶抗血清混淆。

单位定义

在 25 摄氏度下，在肝素存在的情况下培养 5 分钟，一个单位将形成一个复合物并抑制一个单位的牛凝血酶。

外形

从 20 mM Tris (pH 8.0) 冻干

免责声明

仅供研究使用。在法国，在用于科研目的时（包括进口和出口活动（《公共健康法》第L 1211-1条，第2节））该产品为管制品。购买者（即最终用户）需要获得《公共健康法》法第L 1211-1条规定的法国研究部的进口授权。订购本产品即表明您确认已经获得合适的进口授权。

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

法规信息

常规特殊物品

分析证书(COA)

输入产品批号来搜索 分析证书(COA) 。批号可以在产品标签上"批“ （Lot或Batch）字后找到。

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  1. Which document(s) contains shelf-life or expiration date information for a given product?

    If available for a given product, the recommended re-test date or the expiration date can be found on the Certificate of Analysis.

  2. How do I get lot-specific information or a Certificate of Analysis?

    The lot specific COA document can be found by entering the lot number above under the "Documents" section.

  3. What is the specific activity of Antithrombin III from human plasma?

    We do not have strict specifications for the specific activity of the A2221. It is typically in the range of 40-80 units per mg protein. The value is reported on the certificate of analysis for each lot.

  4. What is the molecular weight for Antithrombin III from human plasma. Product A2221?

    The molecular weight of Antithrombin III from human plasma is approximately 53 kDa.

  5. What is Antithrombin III from human plasma, Product A2221, soluble in?

    The manufacturer has found it to be soluble in 50 mM Tris buffer with 150 mM sodium chloride.  (No specific pH or concentration was provided.)

  6. The Antithrombin III from human plasma, Product A2221, vial appears to be empty. What should I do?

    What you are observing is normal for this product. Each vial has sub-milligram amounts in it (either 25 or 125 micrograms), which may not be visible. One should reconstitute the vial, and measure the absorbance at 280 nm to show that it does have protein present.

  7. How do I find price and availability?

    There are several ways to find pricing and availability for our products. Once you log onto our website, you will find the price and availability displayed on the product detail page. You can contact any of our Customer Sales and Service offices to receive a quote.  USA customers:  1-800-325-3010 or view local office numbers.

  8. What is the Department of Transportation shipping information for this product?

    Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product. 

  9. My question is not addressed here, how can I contact Technical Service for assistance?

    Ask a Scientist here.

Alejandro Gugliucci
Life sciences, 82(7-8), 413-418 (2008-01-22)
Conditions in which serum or tissue acrolein levels are high (e.g.: renal failure, heavy smoking, oxidative stress) are also associated with increased thrombogenicity. Another emerging cardiovascular risk factor is homocysteine, and its derivative, homocysteine thiolactone. Antithrombin is one of the
Yu-Fang Hsieh et al.
Biomedical materials (Bristol, England), 12(6), 065004-065004 (2017-10-06)
Biodegradable polymers have potential as a scaffold material for making small diameter artery bypass grafts. To resist thrombosis, maintain biocompatibility and enhance the remodeling of the grafts, it is crucial to modify polymer scaffolds so that the grafts have antithrombogenic
Xiaopeng Tang et al.
Cell research, 30(2), 119-132 (2019-12-08)
Coagulation balance is maintained through fine-tuned interactions among clotting factors, whose physiological concentrations vary substantially. In particular, the concentrations of coagulation proteases (pM to nM) are much lower than their natural inactivator antithrombin (AT, ~ 3 μM), suggesting the existence of other coordinators.
Hao Zhang et al.
Frontiers in cellular and infection microbiology, 11, 677902-677902 (2021-08-03)
Patients with sepsis may progress to acute respiratory distress syndrome (ARDS). Evidence of neutrophil extracellular traps (NETs) in sepsis-induced lung injury has been reported. However, the role of circulating NETs in the progression and thrombotic tendency of sepsis-induced lung injury

实验方案

Thrombin from Bovine Plasma

Thrombin is an endolytic serine protease that selectively cleaves the Arg–Gly bonds of fibrinogen to form fibrin and release fibrinopeptides A and B.

牛血浆凝血酶

凝血酶是一种内溶性丝氨酸蛋白酶，可选择性裂解纤维蛋白原的精氨酸-甘氨酸键，从而形成纤维蛋白并释放纤维蛋白肽A和B。

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