A2201
淀粉样β-蛋白片段35-25
≥95% (HPLC)
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关于此项目
经验公式（希尔记法）:
C45H81N13O14S
化学文摘社编号:
分子量:
1060.27
NACRES:
NA.32
PubChem Substance ID:
UNSPSC Code:
51111800
MDL number:
产品名称
淀粉样β-蛋白片段35-25, ≥95% (HPLC)
InChI key
IDGOADDOQWKZOX-UHFFFAOYSA-N
SMILES string
CCC(C)C(NC(=O)CNC(=O)C(CC(C)C)NC(=O)C(N)CCSC)C(=O)NC(C(C)CC)C(=O)NC(C)C(=O)NCC(=O)NC(CCCCN)C(=O)NC(CC(N)=O)C(=O)NC(CO)C(=O)NCC(O)=O
InChI
1S/C45H81N13O14S/c1-9-24(5)36(57-34(62)20-50-40(67)29(17-23(3)4)54-39(66)27(47)14-16-73-8)45(72)58-37(25(6)10-2)44(71)52-26(7)38(65)49-19-33(61)53-28(13-11-12-15-46)42(69)55-30(18-32(48)60)43(70)56-31(22-59)41(68)51-21-35(63)64/h23-31,36-37,59H,9-22,46-47H2,1-8H3,(H2,48,60)(H,49,65)(H,50,67)(H,51,68)(H,52,71)(H,53,61)(H,54,66)(H,55,69)(H,56,70)(H,57,62)(H,58,72)(H,63,64)
assay
≥95% (HPLC)
form
powder
UniProt accession no.
storage temp.
−20°C
Quality Level
Gene Information
human ... APP(351)
Application
β淀粉样蛋白片段35-25可作为对照肽，用于Aβ诱导的细胞凋亡，研究铁调素过表达对小鼠β淀粉样蛋白诱导的大脑损伤的影响。
Biochem/physiol Actions
β淀粉样前体蛋白(APP)经水解形成β淀粉样蛋白(Aβ)，沉积为阿尔茨海默病的主要生物标志物——大脑淀粉样斑块。APP参与神经发生、突触形成、轴突运输、神经元迁移和神经突生长。还参与线粒体相关内质网膜(MAM)活动、抗菌保护作用、胆固醇和铁稳态过程。β淀粉样蛋白片段35-25是失活对照。
General description
β淀粉样前体蛋白(APP)属于Ⅰ型跨膜蛋白。APP广泛表达，主要存在于突触与神经元中。APP基因位于人染色体 21q21.3。
Other Notes
片段 25-35的N—C反向序列
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
法规信息
常规特殊物品
此项目有
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