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Merck
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安全信息

A2201

Sigma-Aldrich

淀粉样β-蛋白片段35-25

≥95% (HPLC)

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About This Item

经验公式（希尔记法）:
C45H81N13O14S
CAS号:
147740-73-6
分子量:
1060.27
MDL编号:
MFCD00214225
UNSPSC代码:
51111800
PubChem化学物质编号:
24890634
NACRES:
NA.32
价格与库存信息目前不能提供

质量水平

200

方案

≥95% (HPLC)

表单

powder

UniProt登记号

P05067

储存温度

−20°C

SMILES字符串

CCC(C)C(NC(=O)CNC(=O)C(CC(C)C)NC(=O)C(N)CCSC)C(=O)NC(C(C)CC)C(=O)NC(C)C(=O)NCC(=O)NC(CCCCN)C(=O)NC(CC(N)=O)C(=O)NC(CO)C(=O)NCC(O)=O

InChI

1S/C45H81N13O14S/c1-9-24(5)36(57-34(62)20-50-40(67)29(17-23(3)4)54-39(66)27(47)14-16-73-8)45(72)58-37(25(6)10-2)44(71)52-26(7)38(65)49-19-33(61)53-28(13-11-12-15-46)42(69)55-30(18-32(48)60)43(70)56-31(22-59)41(68)51-21-35(63)64/h23-31,36-37,59H,9-22,46-47H2,1-8H3,(H2,48,60)(H,49,65)(H,50,67)(H,51,68)(H,52,71)(H,53,61)(H,54,66)(H,55,69)(H,56,70)(H,57,62)(H,58,72)(H,63,64)

InChI key

IDGOADDOQWKZOX-UHFFFAOYSA-N

基因信息

human ... APP(351)

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Gene Information

human ... IL10RB(3588)

Gene Information

human ... IL9(3578)

Gene Information

human ... IL11(3589)

Gene Information

human ... IL5RA(3568)

species reactivity

human

species reactivity

human

species reactivity

human

species reactivity

human

assay range

inter-assay cv: <12%
intra-assay cv: <10%
sensitivity: 5 pg/mL
standard curve range: 4.12-3000 pg/mL

assay range

inter-assay cv: <12%
intra-assay cv: <10%
sensitivity: 100 pg/mL
standard curve range: 0.04-30 ng/mL

assay range

inter-assay cv: <12%
intra-assay cv: <10%
sensitivity: 3 pg/mL
standard curve range: 3.29-800 pg/mL

assay range

inter-assay cv: <12%
intra-assay cv: <10%
sensitivity: 150 pg/mL
standard curve range: 0.164-40 ng/mL

input

sample type cell culture supernatant(s)
sample type urine
sample type serum
sample type plasma

input

sample type plasma
sample type cell culture supernatant(s)
sample type urine
sample type serum

input

sample type plasma
sample type cell culture supernatant(s)
sample type serum
sample type urine

input

sample type cell culture supernatant(s)
sample type urine
sample type serum
sample type plasma

technique(s)

ELISA: suitable, capture ELISA: suitable

technique(s)

ELISA: suitable, capture ELISA: suitable

technique(s)

ELISA: suitable, capture ELISA: suitable

technique(s)

ELISA: suitable, capture ELISA: suitable

detection method

colorimetric

detection method

colorimetric

detection method

colorimetric

detection method

colorimetric

Amino Acid Sequence

Met-Leu-Gly-Ile-Ile-Ala-Gly-Lys-Asn-Ser-Gly

一般描述

β淀粉样前体蛋白(APP)属于Ⅰ型跨膜蛋白。[1]APP广泛表达，主要存在于突触与神经元中。[2]APP基因位于人染色体 21q21.3。[3]

应用

β淀粉样蛋白片段35-25可作为对照肽，用于Aβ诱导的细胞凋亡，研究铁调素过表达对小鼠β淀粉样蛋白诱导的大脑损伤的影响。[4]

生化/生理作用

β淀粉样前体蛋白(APP)经水解形成β淀粉样蛋白(Aβ)，沉积为阿尔茨海默病的主要生物标志物——大脑淀粉样斑块[1]。APP参与神经发生、突触形成、轴突运输、神经元迁移和神经突生长。还参与线粒体相关内质网膜(MAM)活动、抗菌保护作用、胆固醇和铁稳态过程。[2][1]β淀粉样蛋白片段35-25是失活对照。

其他说明

片段 25-35的N—C反向序列

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

Eyeshields, Gloves, type N95 (US)

法规信息

常规特殊物品
  • 技术规格说明书

    • 历史批次信息供参考:

    分析证书(COA)

    Lot/Batch Number
    SLCC5834
    SLBV2580
    SLBS1693V
    SLBJ6713V
    071M8711

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    Jasmine Chebli et al.
    Scientific reports, 11(1), 19115-19115 (2021-09-29)
    Amyloid precursor protein (APP) is expressed in many tissues in human, mice and in zebrafish. In zebrafish, there are two orthologues, Appa and Appb. Interestingly, some cellular processes associated with APP overlap with cilia-mediated functions. Whereas the localization of APP
    Anatoliy I Yashin et al.
    Mechanisms of ageing and development, 196, 111477-111477 (2021-04-03)
    Emerging evidence from experimental and clinical research suggests that stress-related genes may play key roles in AD development. The fact that genome-wide association studies were not able to detect a contribution of such genes to AD indicates the possibility that
    Alzheimer's disease: amyloid beta-peptide antibody vaccine as plaque remover.
    A Kumar
    Journal of biosciences, 25(4), 315-316 (2000-12-20)
    Elvis Cuevas et al.
    Metabolic brain disease, 34(5), 1365-1374 (2019-07-04)
    The amyloid β-peptide (Aβ) is transported across the blood-brain barrier (BBB) by binding with the receptor for advanced glycation end products (RAGE). Previously, we demonstrated that the Aβ fraction 25-35 (Aβ25-35) increases RAGE expression in the rat hippocampus, likely contributing
    B A Yankner et al.
    Science (New York, N.Y.), 250(4978), 279-282 (1990-10-12)
    The amyloid beta protein is deposited in the brains of patients with Alzheimer's disease but its pathogenic role is unknown. In culture, the amyloid beta protein was neurotrophic to undifferentiated hippocampal neurons at low concentrations and neurotoxic to mature neurons
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