A2172
Anti-α-Actin-1 (ACTA1) antibody
mouse monoclonal, 5C5
别名:
小鼠抗肌动蛋白
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选择尺寸
关于此项目
Conjugate:
unconjugated
Clone:
5C5, monoclonal
Application:
immunohistochemistry (formalin-fixed, paraffin-embedded sections)
immunohistochemistry (frozen sections)
indirect ELISA
western blot
immunohistochemistry (frozen sections)
indirect ELISA
western blot
Species reactivity:
rabbit, carp, rat, sheep, guinea pig, human, snake, bovine, frog
Citations:
215
Technique(s):
immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:500 using human skeletal and cardiac muscle
immunohistochemistry (frozen sections): suitable using human skeletal and cardiac muscle
indirect ELISA: suitable
western blot: suitable
immunohistochemistry (frozen sections): suitable using human skeletal and cardiac muscle
indirect ELISA: suitable
western blot: suitable
产品名称
单克隆抗 肌动蛋白（α-肌节） 小鼠抗, clone 5C5, ascites fluid
biological source
mouse
conjugate
unconjugated
antibody form
ascites fluid
antibody product type
primary antibodies
clone
5C5, monoclonal
contains
15 mM sodium azide
species reactivity
rabbit, carp, rat, sheep, guinea pig, human, snake, bovine, frog
technique(s)
immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:500 using human skeletal and cardiac muscle
immunohistochemistry (frozen sections): suitable using human skeletal and cardiac muscle
indirect ELISA: suitable
western blot: suitable
isotype
IgM
shipped in
dry ice
storage temp.
−20°C
target post-translational modification
unmodified
Quality Level
Gene Information
human ... ACTA1(58), ACTC1(70)
mouse ... Rwdd2a(69519)
rat ... Acta1(29437), Actc1(29275)
Application
单克隆鼠抗肌动蛋白抗体作为大鼠背根神经节共培养的免疫沉淀蛋白的免疫印迹分析的负载对照。
大鼠单克隆抗肌动蛋白（心肌肌动蛋白）抗体可用于蛋白印迹和免疫组织化学应用。
大鼠抗肌动蛋白（α-肌动蛋白）单克隆抗体可用于
- 免疫荧光
- 免疫双标
- 双标记末端脱氧核苷酸转移酶dUTP末端标记（TUNEL）免疫荧光染色。
Biochem/physiol Actions
肌动蛋白是一种细胞骨架蛋白，可调节细胞运动、分泌、吞噬作用和胞质分裂。肌动蛋白的NH2-端可起到抗原作用。该末端还可以调节肌动蛋白相互作用，并且可以与肌球蛋白等蛋白质结合。
Disclaimer
除非我们的目录或产品随附的其他公司文件中另有说明，否则我们的产品预期仅供研究使用，不得用于任何其他目的，包括但不限于未经授权的商业用途、体外诊断用途、离体或体内治疗用途或任何类型的消费或人类或动物应用。
General description
单克隆抗-α-肌动蛋白（小鼠IgM同种型）来源于小鼠骨髓瘤细胞与免疫小鼠脾细胞融合产生的杂交瘤。肌动蛋白是最保守的真核细胞蛋白之一，亚型显示>90%的整体序列同源性。在哺乳动物和鸟类中表达为六种亚型。六种异构体中的四种可代表肌肉组织的分化标记物。其他两种几乎存在于所有细胞中。
Immunogen
兔横纹肌肌动蛋白。
Other Notes
视图需查看肌动蛋白抗体选择指南，请访问www.sigmaaldrich.com/actin。
Physical form
本品以腹水形式提供，含有 0.1% 叠氮化钠作为防腐剂。
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存储类别
10 - Combustible liquids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
常规特殊物品
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Claudin-5 is transcriptionally downregulated resulting in dramatically reduced protein levels in human heart failure. Studies in mice have demonstrated that reduced claudin-5 levels occur prior to cardiac damage and far before reduced whole heart function. Therefore, claudin-5 may be a
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Grauss RW, et al.
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Zhao Q, et al.
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