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Merck
CN
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安全信息

A211150

Sigma-Aldrich

DMT-2′O-Methyl-rA(bz) 磷酰胺

configured for (ÄKTA® and OligoPilot®), configured for ABI

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别名:
DMT-2′-O-甲基-rA(bz)酰胺, N-苯甲酰-5′-O- [双（4-甲氧苯基）苯甲基]-2′-O-甲基-腺苷，3′-[2-氰乙基 N,N-双（1-甲基乙基）亚磷酰胺]
经验公式（希尔记法）:
C48H54N7O8P
CAS号:
110782-31-5
分子量:
887.96
MDL编号:
MFCD00792622
UNSPSC代码:
12352200
PubChem化学物质编号:
329770744
NACRES:
NA.51

生物来源

non-animal source (no BSE/TSE risk)

质量水平

300

产品线

Proligo Reagents

检测方案

≥99% (31P-NMR)
≥99.0% (reversed phase HPLC)

形式

powder

技术

oligo synthesis: suitable

杂质

≤0.1% single unspecified Impurity (reversed phase HPLC)
≤0.3% mA2 (reversed phase HPLC, Hydrolysate)
≤0.3% mA3 (reversed phase HPLC, DMT-rA(bz)me)
≤0.3% water content (Karl Fischer)
≤0.5% P(III) Impurities 100-169ppm (31P-NMR)
≤1.0% mA1 (reversed phase HPLC, DMT-rA(bz)me-DMT)
≤3% residual Solvent content

颜色

white to off-white

λ

conforms (UV/VIS Identity)

适用性

conforms to structure for H-NMR
conforms to structure for LC-MS

相容性

configured for (ÄKTA® and OligoPilot®)
configured for ABI

核苷分析

base: adenosine
base protecting group: benzoyl
2' protecting group: methyl
5' protecting group: DMT
deprotection: standard

储存温度

2-8°C

SMILES字符串

CO[C@@H]1[C@H](OP(OCCC#N)N(C(C)C)C(C)C)[C@@H](COC(c2ccccc2)(c3ccc(OC)cc3)c4ccc(OC)cc4)O[C@H]1n5cnc6c(NC(=O)c7ccccc7)ncnc56

InChI

1S/C48H54N7O8P/c1-32(2)55(33(3)4)64(61-28-14-27-49)63-42-40(62-47(43(42)59-7)54-31-52-41-44(50-30-51-45(41)54)53-46(56)34-15-10-8-11-16-34)29-60-48(35-17-12-9-13-18-35,36-19-23-38(57-5)24-20-36)37-21-25-39(58-6)26-22-37/h8-13,15-26,30-33,40,42-43,47H,14,28-29H2,1-7H3,(H,50,51,53,56)/t40-,42-,43-,47-,64?/m1/s1

InChI key

AZCGOTUYEPXHMJ-PSVHYZMASA-N

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相关类别

一般描述

DMT-2′O-Methyl-rA(bz) Phosphoramidite is a 2′O-Methyl RNA monomer that is compatible with fast deprotection schemes that are based on the application of aliphatic amines, such as methylamine. Modern phosphoramidite-mediated synthesis has enabled routine high-yielding preparations of 2′O-Methyl RNA oligonucleotides. High-quality RNA phosphoramidites are key to low failure rates, the high biological activity of synthesis products, and cost-effectiveness. 2′O-Methyl RNA is a nucleic acid analog that is characterized by the exceptional hybridization properties that it imparts with complementary DNA or RNA, as well as increased stability against enzymatic degradation compared to natural nucleic acids.

应用

2′O-Methyl RNA nucleoside including DMT-2′O-Methyl-rA(bz) Phosphoramidite can be advantageously incorporated in nucleic acid probes with RNA or DNA for in-vivo or in-vitro applications to convey nuclease resistance.The unique combination of properties of 2′O-Methyl RNA had found widespread use in the fields of:
  • Diagnostic probes
  • Aptamer and ribozyme development
  • Mixed 2′O-Methyl-RNA/DNA antisense molecules (a)

法律信息

OligoPilot is a registered trademark of Cytiva
ÄKTA is a registered trademark of Cytiva

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

法规信息

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