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安全信息

A211050

Sigma-Aldrich

DMT-2′O-TBDMS-rA (bz) 亚磷酰胺

configured for (ÄKTA® and OligoPilot®)

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别名:
DMT-2'O-TBDMS-rA(bz)酰胺, N-苯甲酰-5′-O- [双（4-甲氧苯基）苯甲基]-2′-O- [（1,1-二甲基乙基）二甲基硅基]-腺苷，3′-[2-氰乙基 N,N-双（1-甲基乙基）亚磷酰胺]
经验公式（希尔记法）:
C53H66N7O8PSi
CAS号:
104992-55-4
分子量:
988.19
MDL编号:
MFCD00080297
UNSPSC代码:
12352200
PubChem化学物质编号:
329770736
NACRES:
NA.51

生物来源

non-animal source (no BSE/TSE risk)

质量水平

300

产品线

Proligo Reagents

检测方案

≥99% (31P-NMR)
≥99.0% (reversed phase HPLC)

形式

powder

技术

oligo synthesis: suitable

杂质

≤0.3% water content (Karl Fischer)
≤0.5% P(III) Impurities 100-169ppm (31P-NMR)
≤0.5% single Impurity (reversed phase HPLC)
≤3% residual Solvent content

颜色

white to off-white

λ

conforms (UV/VIS Identity)

适用性

conforms to structure for H-NMR
conforms to structure for LC-MS

相容性

configured for (ÄKTA® and OligoPilot®)

核苷分析

base: adenosine
base protecting group: benzoyl
2' protecting group: TBDMS
5' protecting group: DMT
deprotection: standard

储存温度

−20°C

SMILES字符串

COc1ccc(cc1)C(OC[C@H]2O[C@H]([C@H](O[Si](C)(C)C(C)(C)C)[C@@H]2OP(OCCC#N)N(C(C)C)C(C)C)n3cnc4c(NC(=O)c5ccccc5)ncnc34)(c6ccccc6)c7ccc(OC)cc7

InChI

1S/C53H66N7O8PSi/c1-36(2)60(37(3)4)69(65-32-18-31-54)67-46-44(33-64-53(39-21-16-13-17-22-39,40-23-27-42(62-8)28-24-40)41-25-29-43(63-9)30-26-41)66-51(47(46)68-70(10,11)52(5,6)7)59-35-57-45-48(55-34-56-49(45)59)58-50(61)38-19-14-12-15-20-38/h12-17,19-30,34-37,44,46-47,51H,18,32-33H2,1-11H3,(H,55,56,58,61)/t44-,46-,47-,51-,69?/m1/s1

InChI key

FFXHNCNNHASXCT-RFMFGJHUSA-N

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相关类别

一般描述

RNA phosphoramidites, along with RNA CPG, and analogous to DNA synthesis support the synthesis of sequence-specific RNA oligonucleotides for RNA interference (RNAi) and can be used in target validation and other drug development techniques. Modern phosphoramidite-mediated synthesis has enabled routine high-yielding preparations of RNA oligonucleotides. High-quality RNA phosphoramidites are key to low failure rates, the high biological activity of synthesis products, and cost-effectiveness.

Key Features

  • Industry-standard 2′O-TBDMS protective group
  • Consistent lot-to-lot purity and performance
  • Compatible with deprotection methods based on methylamine or AMA
  • Standard RNA phosphoramidites provide excellent coupling results when used with ETT or BTT as an activator; best results are obtained with activator 42
  • Capping with standard acetic anhydride capping reagent rather than with fast Deprotection Cap A
  • Manufactured under a certified ISO 9001 quality system
DMT-2′O-TBDMS-rA(bz) Phosphoramidite is configured for ÄKTA and OligoPilot Synthesizers.

法律信息

OligoPilot is a registered trademark of Cytiva
ÄKTA is a registered trademark of Cytiva

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

法规信息

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