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Merck
CN
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文件

安全信息

A2108

Sigma-Aldrich

AURORA B，活性，GST 标记 人

PRECISIO® Kinase, recombinant, expressed in baculovirus infected Sf9 cells, ≥70% (SDS-PAGE), buffered aqueous glycerol solution

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别名:
AIK2, AIM1, ARK2, AURKB, AurB, IPL1, STK12
UNSPSC代码:
12352200
NACRES:
NA.32

重组

expressed in baculovirus infected Sf9 cells

质量水平

200

产品线

PRECISIO® Kinase

检测方案

≥70% (SDS-PAGE)

形式

buffered aqueous glycerol solution

比活

162-219 nmol/min·mg

分子量

~68 kDa

UniProt登记号

Q96GD4

运输

dry ice

储存温度

−70°C

基因信息

human ... AURKB(9212)

生化/生理作用

AURORA B is a member of the Aurora kinase family that associates with microtubules during chromosome movement and segregation. AURORA B localizes to the microtubules near kinetochores, specifically to the specialized microtubules called K-fibers. AURORA B inhibits the microtubule depolymerizing activity of mitotic centromere-associated kinesin (MCAK) by phosphorylating MCAK on Ser92.This phosphorylation also regulates MCAK translocalization from kinetochores to the centromere. AURORA B has been identified as a target for the development of new anticancer agents since inhibition of AURORA B gives rise to the more pronounced antiproliferative phenotype.

外形

Supplied in 50 mM Tris-HCl, pH 7.5, with 150 mM NaCl, 0.2 5mM DTT, 0.1 mM EGTA, 0.1 mM EDTA, 0.1 mM PMSF, and 25% glycerol.

法律信息

PRECISIO is a registered trademark of Merck KGaA, Darmstadt, Germany

WGK

WGK 1

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)

法规信息

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  1. Which document(s) contains shelf-life or expiration date information for a given product?

    If available for a given product, the recommended re-test date or the expiration date can be found on the Certificate of Analysis.

  2. How do I get lot-specific information or a Certificate of Analysis?

    The lot specific COA document can be found by entering the lot number above under the "Documents" section.

  3. How do I find price and availability?

    There are several ways to find pricing and availability for our products. Once you log onto our website, you will find the price and availability displayed on the product detail page. You can contact any of our Customer Sales and Service offices to receive a quote.  USA customers:  1-800-325-3010 or view local office numbers.

  4. What is the Department of Transportation shipping information for this product?

    Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product. 

  5. What is an appropriate substrate to use as a positive control when testing product A2108, AURORA B, active, GST tagged human? 

    The recommended product to use as a positive control substrate for product A2108, AURORA B, active, GST tagged human, is product SRP5205, MBP, GST tagged human. 

  6. My question is not addressed here, how can I contact Technical Service for assistance?

    Ask a Scientist here.

Paul D Andrews et al.
Developmental cell, 6(2), 253-268 (2004-02-13)
Chromosome orientation and alignment within the mitotic spindle requires the Aurora B protein kinase and the mitotic centromere-associated kinesin (MCAK). Here, we report the regulation of MCAK by Aurora B. Aurora B inhibited MCAK's microtubule depolymerizing activity in vitro, and
Katie B Shannon et al.
Current biology : CB, 12(13), R458-R460 (2002-07-18)
Aurora B family kinases play an essential role in chromosome segregation and cytokinesis. Recent work suggests that the kinase activity is required for bipolar chromosome orientation, kinetochore assembly, spindle checkpoint and microtubule dynamics. Aurora B also has additional functions in

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