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安全信息

A2024

Sigma-Aldrich

阿普拉霉素 硫酸盐

别名:

Nebramycin II

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About This Item

经验公式（希尔记法）:
C21H41N5O11 · xH2SO4
CAS号:
65710-07-8
分子量:
539.58 (free base basis)
EC 号:
265-890-7
MDL编号:
MFCD06200257
UNSPSC代码:
51281633
PubChem化学物质编号:
329770728
NACRES:
NA.85

生物来源

Streptomyces tenebrarius

质量水平

200

表单

powder

颜色

white to brown

抗生素抗菌谱

Gram-negative bacteria

作用机制

protein synthesis | interferes

储存温度

2-8°C

SMILES字符串

OS(O)(=O)=O.CN[C@H]1[C@@H](O)[C@H]2O[C@H](O[C@@H]3[C@@H](N)C[C@@H](N)[C@H](O)[C@H]3O)[C@H](N)C[C@@H]2O[C@@H]1O[C@H]4O[C@H](CO)[C@@H](N)[C@H](O)[C@H]4O

InChI

1S/C21H41N5O11.H2O4S/c1-26-11-14(30)18-8(33-20(11)37-21-16(32)13(29)10(25)9(4-27)34-21)3-7(24)19(36-18)35-17-6(23)2-5(22)12(28)15(17)31;1-5(2,3)4/h5-21,26-32H,2-4,22-25H2,1H3;(H2,1,2,3,4)/t5-,6+,7-,8+,9-,10-,11+,12+,13+,14-,15-,16-,17-,18+,19+,20-,21-;/m1./s1

InChI key

WGLYHYWDYPSNPF-RQFIXDHTSA-N

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一般描述

化学结构：氨基糖苷类

应用

阿霉素用于研究细菌和原核生物的抗生素耐药性以及蛋白质合成易位步骤抑制。

生化/生理作用

阿霉素通过阻断易位抑制蛋白质合成。它还能结合真核解码位点。在低浓度下，它会抑制延伸和诱导mRNA在蛋白质合成的误读。

包装

1G，5G

其他说明

保存于密闭容器内，置于干燥通风处。请存放在干燥处。储存等级（TRGS 510）：不可燃急性毒性3类/有毒有害物质或引起慢性影响的有害物质。

象形图

Health hazard
GHS08

警示用语：

Danger

危险声明

H360FD

危险分类

Repr. 1B

储存分类代码

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges, type P3 (EN 143) respirator cartridges

法规信息

监管及禁止进口产品

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分析证书(COA)

Lot/Batch Number
0000395317
0000356526
0000334301
0000356526
0000380005

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Min-Jung Choi et al.
Foodborne pathogens and disease, 8(1), 119-123 (2011-01-11)
A total of 1921 Escherichia coli isolated from healthy animals (501 from cattle, 832 from pigs, and 588 from chickens) and 237 isolates from diseased pigs were tested to determine the prevalence of apramycin and gentamicin resistance in Korea during
C M Yates et al.
The Journal of antimicrobial chemotherapy, 54(2), 534-537 (2004-07-03)
The aminoglycoside apramycin has been used extensively in animal husbandry in the UK since 1978. This study aimed to determine both whether calves that had never been treated with aminoglycoside antibiotics harboured apramycin-resistant (apr(R)) commensal Escherichia coli, and the mode
Jiro Kondo et al.
Chembiochem : a European journal of chemical biology, 8(14), 1700-1709 (2007-08-21)
The lack of absolute prokaryotic selectivity of natural antibiotics is widespread and is a significant clinical problem. The use of this disadvantage of aminoglycoside antibiotics for the possible treatment of human genetic diseases is extremely challenging. Here, we have used
Serena Bernacchi et al.
Nucleic acids research, 35(21), 7128-7139 (2007-10-19)
Owing to a striking, and most likely fortuitous, structural and sequence similarity with the bacterial 16 S ribosomal A site, the RNA kissing-loop complex formed by the HIV-1 genomic RNA dimerization initiation site (DIS) specifically binds 4,5-disubstituted 2-deoxystreptamine (2-DOS) aminoglycoside
T-W Hahn et al.
Journal of animal science, 84(6), 1422-1428 (2006-05-16)
Two experiments were conducted to evaluate the efficacy of beta-glucan on growth performance, nutrient digestibility, and immunity in weanling pigs. In Exp. 1, 210 weanling pigs (6.38 +/- 0.92 kg of BW) were fed dietary beta-glucan (0, 0.01, 0.02, 0.03
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