A1895
金精三羧酸
≥85% purity (titration), practical grade, powder
别名:
ATA
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关于此项目
经验公式（希尔记法）:
C22H14O9
化学文摘社编号:
分子量:
422.34
NACRES:
NA.47
PubChem Substance ID:
UNSPSC Code:
12171500
EC Number:
224-628-1
MDL number:
产品名称
金精三羧酸, practical grade, ≥85% (titration), powder
InChI key
GIXWDMTZECRIJT-UHFFFAOYSA-N
InChI
1S/C22H14O9/c23-16-4-1-10(7-13(16)20(26)27)19(11-2-5-17(24)14(8-11)21(28)29)12-3-6-18(25)15(9-12)22(30)31/h1-9,23-24H,(H,26,27)(H,28,29)(H,30,31)
SMILES string
OC(=O)c1cc(ccc1O)C(\c2ccc(O)c(c2)C(O)=O)=C3\C=CC(=O)C(=C3)C(O)=O
grade
practical grade
assay
≥85% (titration)
form
powder
technique(s)
titration: suitable
color
red to very dark red, and Red-Brown andBrown-Red
mp
300 °C (lit.)
solubility
1 M NH4OH: 10 mg/mL
application(s)
diagnostic assay manufacturing
hematology
histology
storage temp.
room temp
Quality Level
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Application
- 金合欢酸已用于显示出对微小隐孢子虫的抗隐孢子虫活性。
- 已用作供测试品鉴别抗冠状病毒 N7-MTase（鸟嘌呤-N7-甲基转移酶）的抑制剂。
- 曾被用作核糖核酸酶抑制剂。
Biochem/physiol Actions
易于在水溶液中聚合，形成可抑制蛋白质-核酸相互作用的稳定自由基。它是核糖核酸酶和拓扑异构酶 II 的强效抑制剂，作用机理是阻止核酸与酶的结合。其可促进酪氨酸磷酸化过程，包括 NB2 淋巴瘤细胞中的 Jak2/STAT5 通路，神经母细胞瘤细胞中的 ErbB4，以及 PC12 细胞中的 MAP 激酶、Shc 蛋白、磷脂酰肌醇 3-激酶和磷脂酶 Cγ。抑制细胞凋亡。它可阻止对 Ca2+ 不通透的 GluR2 受体的下调并抑制钙蛋白酶，这是一种在细胞凋亡过程中被活化的 Ca2+ -激活蛋白酶。
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
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