product name
金精三羧酸, practical grade, ≥85% (titration), powder
等级
practical grade
质量水平
检测方案
≥85% (titration)
形式
powder
颜色
red to very dark red, and Red-Brown andBrown-Red
mp
300 °C (lit.)
溶解性
1 M NH4OH: 10 mg/mL
应用
diagnostic assay manufacturing
hematology
histology
储存温度
room temp
SMILES字符串
OC(=O)c1cc(ccc1O)C(\c2ccc(O)c(c2)C(O)=O)=C3\C=CC(=O)C(=C3)C(O)=O
InChI
1S/C22H14O9/c23-16-4-1-10(7-13(16)20(26)27)19(11-2-5-17(24)14(8-11)21(28)29)12-3-6-18(25)15(9-12)22(30)31/h1-9,23-24H,(H,26,27)(H,28,29)(H,30,31)
InChI key
GIXWDMTZECRIJT-UHFFFAOYSA-N
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应用
- 金合欢酸已用于显示出对微小隐孢子虫的抗隐孢子虫活性。
- 已用作供测试品鉴别抗冠状病毒 N7-MTase(鸟嘌呤-N7-甲基转移酶)的抑制剂。
- 曾被用作核糖核酸酶抑制剂。
生化/生理作用
易于在水溶液中聚合,形成可抑制蛋白质-核酸相互作用的稳定自由基。它是核糖核酸酶和拓扑异构酶 II 的强效抑制剂,作用机理是阻止核酸与酶的结合。其可促进酪氨酸磷酸化过程,包括 NB2 淋巴瘤细胞中的 Jak2/STAT5 通路,神经母细胞瘤细胞中的 ErbB4,以及 PC12 细胞中的 MAP 激酶、Shc 蛋白、磷脂酰肌醇 3-激酶和磷脂酶 Cγ。抑制细胞凋亡。它可阻止对 Ca2+ 不通透的 GluR2 受体的下调并抑制钙蛋白酶,这是一种在细胞凋亡过程中被活化的 Ca2+ -激活蛋白酶。
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
dust mask type N95 (US), Eyeshields, Gloves
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