A1862
Alpidem
≥98% (HPLC), powder
别名:
6-Chloro-2-(4-chlorophenyl)-N,N-dipropyl-imidazo[1,2-a]pyridine-3-acetamide, 6-Chloro-2-(p-chlorophenyl)-N,N-dipropylimidazo(1,2-a)pyridine-3-acetamide, Ananxyl, SL 80.0342-00
登录查看公司和协议定价
所有图片(1)
About This Item
经验公式（希尔记法）:
C21H23Cl2N3O
CAS号:
分子量:
404.33
MDL编号:
UNSPSC代码:
12352200
PubChem化学物质编号:
推荐产品
![（酪氨酸[SO3H]27）胆囊收缩素片段26-33酰胺 ≥97% (HPLC), powder](/deepweb/assets/sigmaaldrich/product/structures/125/021/32eb71ec-73e5-4cfc-94d0-ebcf5e784e39/640/32eb71ec-73e5-4cfc-94d0-ebcf5e784e39.png)
方案
≥98% (HPLC)
表单
powder
颜色
white to tan
溶解性
DMSO: ≥10 mg/mL
创始人
Sanofi Aventis
储存温度
2-8°C
SMILES字符串
CCCN(CCC)C(=O)Cc1c(nc2ccc(Cl)cn12)-c3ccc(Cl)cc3
InChI
1S/C21H23Cl2N3O/c1-3-11-25(12-4-2)20(27)13-18-21(15-5-7-16(22)8-6-15)24-19-10-9-17(23)14-26(18)19/h5-10,14H,3-4,11-13H2,1-2H3
InChI key
JRTIDHTUMYMPRU-UHFFFAOYSA-N
基因信息
human ... TSPO(706)
生化/生理作用
Alpidem is a potent antagonist of peripheral benzodiazepine receptor (PBR) that is located on the outer mitochondrial membrane and interacts with the mitochondrial permeability transition (MPT) pore. Alpidem is an anxiolytic drug from the imidazopyridine family. Alpidem acts selectively on the α3 receptor subtype and to a lesser extent at the α1 subtype (Kd of 0.33nM and 1.67nM respectively), of the benzodiazepine receptor.
Alpidem is a potent peripheral benzodiazepine receptor (PBR) antagonist.
特点和优势
This compound is a featured product for Neuroscience research. Click here to discover more featured Neuroscience products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
This compound is featured on the GABAA Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
This compound was developed by Sanofi Aventis. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.
历史批次信息供参考:
分析证书(COA)
Lot/Batch Number
A K Mehta et al.
Brain research, 704(2), 289-297 (1995-12-18)
The binding of [3H]Ro 15-4513, [3H]flunitrazepam and [3H]flumazenil to rat CNS membranes was studied at 2 degrees C, 22 degrees C and 37 degrees C using ligand concentrations ranging from approximately 0.06 nM to 10 microM. Analysis of the binding
Divya K Nair et al.
Organic letters, 14(17), 4580-4583 (2012-08-28)
A variety of functionalized imidazo[1,2-a]pyridines have been synthesized through a one-pot, room temperature, and reagent-free reaction between MBH acetates of nitroalkenes and 2-aminopyridines. The reaction involves a cascade inter-intramolecular double aza-Michael addition of 2-aminopyridines to MBH acetates. Our methodology is
P H Bernard et al.
Journal of submicroscopic cytology and pathology, 28(1), 5-12 (1996-01-01)
Hepatic stellate cells were studied by immuno-cytochemistry with anti smooth muscle alpha-actin antibody (an activation marker for these cells) and electron microscopy, in eleven patients transplanted for fulminant or subfulminant hepatitis. Numerous smooth muscle alpha-actin positive cells were found in
L Frattola et al.
The British journal of psychiatry : the journal of mental science, 165(1), 94-100 (1994-07-01)
We investigated whether a new non-benzodiazepine anti-anxiety drug, alpidem, produces weaker withdrawal symptoms than alprazolam. Under a double-blind procedure, 122 patients suffering from general anxiety disorders were randomly allocated to either alpidem (50 mg, three times a day) or alprazolam
P A Maguire et al.
European journal of pharmacology, 280(2), 167-173 (1995-07-04)
An alpidem-insensitive benzodiazepine binding site in the rat spinal cord has recently been identified in our laboratory. We report here the binding of 23 1,4-benzodiazepines to this site using [3H]Ro15-4513 (ethyl-8-azido-6-dihydro-5-methyl-4H-imidazo[1,2- a][1,4]benzodiazepine-3-carboxylate) in the presence of 65 microM alpidem (6-chloro-2-(4-chlorophenyl)-N,N-
商品
We offer many products related to GABAA receptors for your research needs.
DISCOVER Bioactive Small Molecules for Neuroscience
我们的科学家团队拥有各种研究领域经验，包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.
联系技术服务部门