应用
S-乙酰辅酶 A 合成酶可用于研究各种代谢途径，例如糖酵解、糖异生、丙酮酸代谢和 CO2 固定。它也可以用于基因表达研究。
来自面包酵母的 S-乙酰辅酶 A 合成酶已用于合成 5′-磷酸四磷酸腺苷和 5′-磷酸五磷酸腺苷。
生化/生理作用
乙酰辅酶 A 合成酶催化乙酰辅酶 A 的产生。它参与细胞核中的组蛋白乙酰化。它可能参与不可发酵碳源（如甘油）的生长。乙酰辅酶 A 合成酶是由乙酸盐、乙醛和乙醇诱导的。
包装
包装尺寸基于蛋白质含量。
单位定义
在 37°C，pH 7.5 下，一个单位每分钟将从乙酸盐、ATP 和辅酶 A 生成 1.0 μ 摩尔 S-乙酰辅酶 A。
外形
冻干粉末，含有稳定剂，如磷酸钾、蔗糖和还原型谷胱甘肽
警示用语：
Danger
危险声明
预防措施声明
危险分类
Resp. Sens. 1
WGK
WGK 1
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, type N95 (US)
法规信息
常规特殊物品
Heidi A Crosby et al.
The Journal of biological chemistry, 287(19), 15590-15601 (2012-03-15)
N-lysine acetylation is a posttranslational modification that has been well studied in eukaryotes and is likely widespread in prokaryotes as well. The central metabolic enzyme acetyl-CoA synthetase is regulated in both bacteria and eukaryotes by acetylation of a conserved lysine
Hua Xu et al.
Biochemistry, 50(26), 5883-5892 (2011-06-02)
Recent proteomics studies have revealed that protein acetylation is an abundant and evolutionarily conserved post-translational modification from prokaryotes to eukaryotes. Although an astonishing number of acetylated proteins have been identified in those studies, the acetyltransferases that target these proteins remain
Sandy Thao et al.
mBio, 2(5), doi:10-doi:10 (2011-10-20)
In the bacterium Salmonella enterica, the CobB sirtuin protein deacetylase and the Gcn5-related N(ε)-acetyltransferase (GNAT) Pat control carbon utilization and metabolic flux via N(ε)-lysine acetylation/deacetylation of metabolic enzymes. To date, the S. enterica Pat (SePat) acetyltransferase has not been biochemically
Saurabh Sahar et al.
The Journal of biological chemistry, 289(9), 6091-6097 (2014-01-16)
The circadian clock regulates a wide range of physiological and metabolic processes, and its disruption leads to metabolic disorders such as diabetes and obesity. Accumulating evidence reveals that the circadian clock regulates levels of metabolites that, in turn, may regulate
Sara Castaño-Cerezo et al.
Molecular microbiology, 82(5), 1110-1128 (2011-11-09)
Lysine acetylation is a well-established post-translational modification widely conserved and distributed in bacteria. Although multiple regulatory roles have been proved, little is known about its regulation. Here, we present evidence that the transcription of the Gcn5-like acetyltransferase YfiQ of Escherichia
商品
Enzyme Reagent Coenzyme A (CoA, CoASH or HSCoA) is the key cofactor in first step of the TCA cycle, responsible for transferring the acetyl group from pyruvate oxidation to oxaloacetate yielding citrate. Available through Sigma-Aldrich online.
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