推荐产品
质量水平
检测方案
≥98% (HPLC)
形式
powder
储存条件
desiccated
颜色
white to beige
溶解性
H2O: 10 mg/mL
λmax
258 nm
储存温度
−20°C
SMILES字符串
CCN(CC)CC.Nc1ncnc2n(cnc12)[C@@H]3O[C@@H]4COP(O)(=S)O[C@H]4[C@H]3O
InChI
1S/C10H12N5O5PS.C6H15N/c11-8-5-9(13-2-12-8)15(3-14-5)10-6(16)7-4(19-10)1-18-21(17,22)20-7;1-4-7(5-2)6-3/h2-4,6-7,10,16H,1H2,(H,17,22)(H2,11,12,13);4-6H2,1-3H3/t4-,6-,7-,10-,21?;/m1./s1
InChI key
OXIPZMKSNMRTIV-NVGWRVNNSA-N
应用
Rp-腺苷-3′，5′-环一硫代磷酸三乙酯铵盐已被用作cAMP的拮抗剂，以阻断cAMP-PKA信号通路。
生化/生理作用
Rp-腺苷-3′，5′-环一硫代磷酸三乙酯铵盐能够抑制蛋白激酶A（PKA）。
腺苷-3′，5′-环状单硫代磷酸酯 Rp-非对映异构体。cAMP（cAMP 依赖性蛋白激酶I 和 II）激活作用的特异性膜渗透性抑制剂；对环核苷酸磷酸二酯酶具有抗性；在许多系统中阻断 cAMP 介导的作用。
特点和优势
这种化合物是环核苷酸研究的特色产品。点击此处发现更多特色环核苷酸产品。在sigma.com/discover-bsm可了解更多关于生物活性小分子的其他研究领域。
注意
非常吸湿。储存于干燥处。
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, type N95 (US)
Role of PLC-PIP2 and cAMP-PKA signal pathways in radiation-induced immune-suppressing effect
Dong JC, et al.
Biomedical and Environmental Sciences : Bes, 27(1), 27-34 (2014)
Takashi Matsuura et al.
Journal of oral science, 60(4), 634-637 (2018-06-01)
Once a tooth develops deep caries and the dental pulp tissue is irreversibly infected, the infected dental pulp tissue should be removed, and filling material should be placed in the root canal. Endodontically treated teeth are prone to root fracture
Carmen Müllner et al.
The FEBS journal, 276(21), 6218-6226 (2009-09-22)
Besides being activated by G-protein beta/gamma subunits, G-protein activated potassium channels (GIRKs) are regulated by cAMP-dependent protein kinase. Back-phosphorylation experiments have revealed that the GIRK1 subunit is phosphorylated in vivo upon protein kinase A activation in Xenopus oocytes, whereas phosphorylation
Hiroyuki Koide et al.
Journal of controlled release : official journal of the Controlled Release Society, 295, 13-20 (2018-12-24)
Protein affinity reagents (PARs), frequently antibodies, are essential tools for basic research, diagnostics, separations and for clinical applications. However, there is growing concern about the reproducibility, quality and cost of recombinant and animal-derived antibodies. This has prompted the development of
J D Rothermel et al.
The Journal of biological chemistry, 259(13), 8151-8155 (1984-07-10)
The ability of the Rp diastereomer of adenosine cyclic 3',5'-phosphorothioate (Rp cAMPS) to inhibit glucagon-induced glycogenolysis was studied in hepatocytes isolated from fed rats. Preincubation of the cells for 20 min with progressively higher concentrations of Rp cAMPS followed by
商品
Cyclic nucleotides like cAMP modulate cell function via PKA activation and ion channels.
我们的科学家团队拥有各种研究领域经验，包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.
联系技术服务部门