推荐产品
生物来源
goat
质量水平
重组
expressed in goat
偶联物
unconjugated
抗体形式
affinity isolated antibody
抗体产品类型
primary antibodies
克隆
polyclonal
表单
lyophilized powder
种属反应性
human
技术
ELISA: suitable
immunohistochemistry (formalin-fixed, paraffin-embedded sections): 5-15 μg/mL
neutralization: suitable
western blot: 0.1 μg/mL
1 of 4
此商品 | SRP2056 | SRP2045 | SRP2139 |
|---|---|---|---|
| biological source human | biological source human | biological source human | biological source human |
| assay ≥80% (SDS-PAGE) | assay ≥80% (SDS-PAGE) | assay ≥70% (SDS-PAGE) | assay ≥80% (SDS-PAGE) |
| recombinant expressed in E. coli | recombinant expressed in E. coli | recombinant expressed in E. coli | recombinant expressed in E. coli |
| concentration 450 μg/mL | concentration 350 μg/mL | concentration 500 μg/mL | concentration 300 μg/mL |
| form frozen liquid | form frozen liquid | form frozen liquid | form frozen liquid |
| mol wt ~57.8 kDa | mol wt ~33.6 kDa | mol wt ~60 kDa | mol wt ~58.2 kDa |
一般描述
Activin A protein belongs to the transforming growth factor-β (TGF-β) superfamily. This protein is a homodimer of two βA subunits. The INHBA gene is located on the human chromosome at 7p14.1.
免疫原
recombinant human activin A expressed in CHO cells.
应用
Anti-Activin A antibody can be used for immunohistochemistry (5-15 μg/mL), western blot (0.1 μg/mL) and neutralization assays.
Anti-Activin A antibody produced in goat has been used in immunohistochemical staining.
生化/生理作用
Activin A protein is involved in regulating developmental genes such as cell cycle regulators like p21, p15, paired box protein (Pax-6) and hormones like follicle-stimulating hormone (FSH). This protein also regulates its antagonist like follistatin and mothers against decapentaplegic homolog 7 (SMAD7). Activin A protein binds to the type 1 receptor activin receptor type 1B (ActR1B) and type 2 receptor activin receptor 2A and 2B (ActRIIA and ActRIIB). Activin A gene is highly expressed in esophageal carcinoma, lung adenocarcinoma, and malignant pleural mesothelioma (MPM). This gene expression is decreased during breast cancer, neuroblastoma, and hepatocellular carcinoma (HCC). Activins bind to the type II Activin receptor triggering phosphorylation of type I Activin receptor (ALK4) and activation of downstream pathways such as proliferation and apoptosis. Activin acts as a tumor suppressor by reducing cell proliferation in cancer cells.
外形
Lyophilized from 0.2 μm-filtered solution in phosphate buffered saline containing carbohydrates.
免责声明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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储存分类代码
11 - Combustible Solids
WGK
WGK 1
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
常规特殊物品
Nobuya Daitoku et al.
Oncology reports, 47(6) (2022-04-22)
Activin A is a member of the transforming growth factor‑β superfamily of cytokines and displays various pathophysiological activities, including regulation of muscle catabolism and atrophy. Activin A expression is upregulated in several human cancer types and in certain pathologies, its expression is
Cornelia Schuster et al.
The journal of pathology. Clinical research, 5(1), 53-62 (2018-09-19)
The incidence of malignant melanoma is rising worldwide and survival for metastatic disease is still poor. Recently, new treatment options have become available. Still, predictive biomarkers are needed to optimise treatment for this patient group. In this study, we investigated
Alexander Ries et al.
Expert opinion on therapeutic targets, 24(10), 985-996 (2020-07-24)
Activin A is involved in the regulation of a surprisingly broad number of processes that are relevant for cancer development and treatment; it is implicated in cell autonomous functions and multiple regulatory functions in the tumor microenvironment. This article summarizes
Sida Peng et al.
International journal of clinical and experimental pathology, 13(5), 854-868 (2020-06-09)
Up-regulated expression of INHBA has been reported in multiple malignant tumors. However, in nasopharyngeal carcinoma (NPC), the expression pattern and clinical significance of INHBA are still unclear. This study aimed to detect the expression of INHBA and its prognostic significance
Kun-Ming Rau et al.
Anticancer research, 31(5), 1713-1720 (2011-05-28)
Molecular mechanisms responsible for carcinogenesis in upper urinary tract urothelial carcinoma (UUTUC) are not yet clear. This study aimed to examine and correlate the subcellular localization of activin A, maspin, and the androgen receptor (AR) with demographic characteristics, pathological grade
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