所有图片(1)
别名:
cis-2-[[1-(4-Chlorophenyl)-1H-tetrazol-5-yl]thio]-1-(1,2,3,4,4a,9b-hexahydro-2,8-dimethyl-5H-pyrido[4,3-b]indol-5-yl)-ethanone, cis-5-({[1-(4-chlorophenyl)-1H-tetraazol-5-yl]sulfanyl}acetyl)-2,8-dimethyl-2,3,4,4a,5,9b-hexahydro-1H-pyrido[4,3-b]indole
经验公式（希尔记法）:
C22H23ClN6OS
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质量水平
检测方案
≥98% (HPLC)
形式
powder
储存条件
desiccated
颜色
off-white to brown
溶解性
DMSO: >9 mg/mL (warmed)
储存温度
2-8°C
SMILES字符串
CN1CC[C@@H]2[C@H](C1)c3cc(C)ccc3N2C(=O)CSc4nnnn4-c5ccc(Cl)cc5
InChI
1S/C22H23ClN6OS/c1-14-3-8-19-17(11-14)18-12-27(2)10-9-20(18)28(19)21(30)13-31-22-24-25-26-29(22)16-6-4-15(23)5-7-16/h3-8,11,18,20H,9-10,12-13H2,1-2H3/t18-,20-/m1/s1
InChI key
GJNBAISSZRNGTM-UYAOXDASSA-N
应用
AG-205 has been used to investigate the neuroprotective effects of norgestrel on stressed photoreceptors. It has also been used to study the effect of blocking progesterone receptor membrane component 1 in 661W cells.
生化/生理作用
AG-205 is a Pgrmc1 (progesterone receptor membrane component 1) inhibitor. AG-205 alters the spectroscopic properties of the Pgrmc1-heme complex. AG-205 inhibits cancer cell viability and cancer cell progression. acting preferentially on Pgrmc1-expressing cells.
Pgrmc1 is a cytochrome associated protein. It is found to be upregulated in several cancer types such as breast, lung and gastric cancer. Pgrmc1 regulates the epidermal growth factor signaling.
特点和优势
This compound is featured on the Nuclear Receptors (Steroids) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
AACR 2016: Abstracts 1-2696 (2016)
Meng Guo et al.
Scientific reports, 6, 36869-36869 (2016-11-17)
Well-timed progression of primordial folliculogenesis is essential for mammalian female fertility. Progesterone (P4) inhibits primordial follicle formation under physiological conditions; however, P4 receptor that mediates this effect and its underlying mechanisms are unclear. In this study, we used an in
Progesterone receptor signalling in retinal photoreceptor neuroprotection
Wyse J, et al.
Journal of Neurochemistry, 136(1), 63-77 (2016)
Progesterone analogue protects stressed photoreceptors via bFGF-mediated calcium influx
Wyse-Jackson AC, et al.
The European Journal of Neuroscience, 44(12), 3067-3079 (2016)
Karlie A Intlekofer et al.
PloS one, 14(4), e0215389-e0215389 (2019-04-27)
Progesterone membrane receptor component 1 (Pgrmc1) is a cytochrome b5-related protein with wide-ranging functions studied most extensively in non-neural tissues. We previously demonstrated that Pgrmc1 is widely distributed in the brain with highest expression in the limbic system. To determine
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