推荐产品
生物来源
rabbit
质量水平
偶联物
unconjugated
抗体形式
IgG fraction of antiserum
抗体产品类型
primary antibodies
克隆
polyclonal
表单
PBS solution
分子量
antigen ~52 kDa
种属反应性
human
技术
western blot: 1:500-1:2,000
UniProt登记号
运输
dry ice
储存温度
−20°C
靶向翻译后修饰
unmodified
基因信息
human ... ATP6AP1(537)
一般描述
ATPase H+ transporting accessory protein 1 (ATP6AP1) is an accessory subunit of the V-ATPase. This gene is located on human chromosome Xq28. ATP6AP1 is also referred as Ac45. It is abundantly expressed a high levels in neuronal and (neuro-) endocrine cells and osteoclasts.
免疫原
synthetic peptide corresponding to amino acids 451-465 of human ATP6AP1
应用
Rabbit anti-ATP6AP1 (451-465) antibody can be used for western blot (1:500-1:2,000) assays.
Yale Center for High Throughput Cell Biology IF-tested antibodies. Each antibody is tested by immunofluorescence against HUVEC cells using the Yale HTCB IF protocol. To learn more about us and Yale Center for High Throughput Cell Biology partnership, visit sigma.com/htcb-if.
生化/生理作用
ATPase H+ transporting accessory protein 1 (ATP6AP1) is known to cause an X-linked N-glycosylation syndrome with liver disease. It is essential for endosomal acidification. It also participates in membrane trafficking and Ca2+-dependent membrane fusion.
外形
0.01M 磷酸缓冲盐溶液，pH 7.4，含 15mM 叠氮化钠。
免责声明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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储存分类代码
12 - Non Combustible Liquids
WGK
nwg
法规信息
常规特殊物品
Expanding the phenotype of metabolic cutis laxa with an additional disorder of N-linked protein glycosylation
Witters P, et al.
European Journal of Human Genetics, 26(5), 618-618 (2018)
Loss-of-function mutations in ATP6AP1 and ATP6AP2 in granular cell tumors
Pareja F, et al.
Nature Communications, 9(1), 3533-3533 (2018)
Jason J Gokey et al.
Developmental biology, 407(1), 115-130 (2015-08-09)
Asymmetric fluid flows generated by motile cilia in a transient 'organ of asymmetry' are involved in establishing the left-right (LR) body axis during embryonic development. The vacuolar-type H(+)-ATPase (V-ATPase) proton pump has been identified as an early factor in the
Fresia Pareja et al.
Nature communications, 9(1), 3533-3533 (2018-09-01)
Granular cell tumors (GCTs) are rare tumors that can arise in multiple anatomical locations, and are characterized by abundant intracytoplasmic granules. The genetic drivers of GCTs are currently unknown. Here, we apply whole-exome sequencing and targeted sequencing analysis to reveal
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