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生物来源
rabbit
偶联物
unconjugated
抗体形式
affinity isolated antibody
抗体产品类型
primary antibodies
克隆
polyclonal
形式
PBS solution
分子量
antigen ~250 kDa
种属反应性
rat, mouse, human
浓度
~1 mg/mL
技术
immunohistochemistry (formalin-fixed, paraffin-embedded sections): 20-40 μg/mL using heat-retrieved tissue sections from human heart by biotin/ExtrAvidin-Peroxidase
indirect immunofluorescence: 20-40 μg/mL using differentiated rat L8 cells
western blot: 2.5-5 μg/mL using whole extract of differentiated mouse C2 cells
UniProt登记号
运输
dry ice
储存温度
−20°C
靶向翻译后修饰
unmodified
基因信息
human ... SVIL(6840)
mouse ... Svil(225115)
rat ... Svil(361256)
一般描述
Archvillin is a muscle-specific isoform of Supervillin. Archvillin binds F-actin and is believed to be involved in myogenesis and muscle cell migration. Archvillin binds ERK and modulates ERK signaling in smooth cells of the aortas of ferrets.
Rabbit anti-archvillin antibody binds to human, mouse, and rat archvillin.
免疫原
synthetic peptide corresponding to amino acid residues 650-666 of human archvillin. The corresponding sequence is identical in mouse.
应用
Rabbit anti-archvillin antibody can be used for immunohistochemistry at 20-40 μg/mL using heat-retrieved tissue sections from human heart by biotin/ExtrAvidin-Peroxidase. The antibody can also be used for indirect immunofluorescence at 20-40 μg/mL using differentiated rat L8 cells. Furthermore, the antibody is suitable for use in western blot (2.5-5 μg/mL using whole extract of differentiated mouse C2 cells) assays.
外形
Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide
免责声明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
WGK
nwg
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
新产品
Samudra S Gangopadhyay et al.
The Journal of biological chemistry, 284(26), 17607-17615 (2009-05-02)
ERK influences a number of pathways in all cells, but how ERK activities are segregated between different pathways has not been entirely clear. Using immunoprecipitation and pulldown experiments with domain-specific recombinant fragments, we show that smooth muscle archvillin (SmAV) binds
Zhiyou Fang et al.
The Journal of biological chemistry, 288(11), 7918-7929 (2013-02-06)
Integrin-based adhesions promote cell survival as well as cell motility and invasion. We show here that the adhesion regulatory protein supervillin increases cell survival by decreasing levels of the tumor suppressor protein p53 and downstream target genes. RNAi-mediated knockdown of
Janelle M Spinazzola et al.
Human molecular genetics, 24(9), 2470-2481 (2015-01-22)
Loss of gamma-sarcoglycan (γ-SG) induces muscle degeneration and signaling defects in response to mechanical load, and its absence is common to both Duchenne and limb girdle muscular dystrophies. Growing evidence suggests that aberrant signaling contributes to the disease pathology; however
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