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一般描述
盐酸金刚烷胺{三环-[3,3,1,1]- deean-l-胺盐酸盐是一种以盐酸金刚乙胺为类似物的药物。
应用
使用盐酸金刚烷胺：
- 测定其在缓解手术引起的认知障碍方面的有效性
- 预培养多能干细胞(MSC)并研究细胞内化途径
- 确定金刚烷减毒脓毒症是否会诱发神经炎症和学习记忆功能障碍
- 预培养原代培养大鼠牙髓干细胞(rDPSC)
- 确定内化途径
生化/生理作用
盐酸金刚烷胺在体内和体外均对流感病毒有效。它还可作为N-甲基-D-天冬氨酸(NMDA)型谷氨酸受体的拮抗剂。金刚烷胺在多巴胺的释放中起着重要的作用，用于阻止多巴胺的再摄取并阻断小胶质细胞激活和神经炎症。
多巴胺释放剂用于治疗帕金森综合征和药物引起的锥体外系反应。
特点和优势
该化合物是 ADME Tox research 的特色产品。单击此处可发现更多ADME Tox 产品。前往sigma.com/discover-bsm了解更多关于其他研究领域的生物活性小分子。
警示用语：
Warning
危险声明
预防措施声明
危险分类
Acute Tox. 4 Oral
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
dust mask type N95 (US), Eyeshields, Gloves
从最新的版本中选择一种：
分析证书(COA)
Lot/Batch Number
Effect of aminated mesoporous bioactive glass nanoparticles on the differentiation of dental pulp stem cells
Lee J H, et al.
Testing, 11(3), e0150727-e0150727 (2016)
Guvenc Dogan et al.
Turkish neurosurgery, 30(1), 60-68 (2020-02-25)
To investigate the neuroprotective effect of a N-methyl-D-aspartate (NMDA) receptor antagonist (amantadine) in an experimental spinal cord injury (SCI) model. Thirty male Spragueâ€"Dawley rats were divided into three groups: control (I), SCI (II), and SCI + amantadine (III). SCI was
Amantadine ameliorates dopamine-releasing deficits and behavioral deficits in rats after fluid percussion injury
Huang E Y K, et al.
Testing, 9(1), e86354-e86354 (2014)
John Whyte et al.
Archives of physical medicine and rehabilitation, 94(10), 1877-1883 (2013-06-06)
To assess the incidence of medical complications in patients with recent traumatic disorders of consciousness (DOCs). Data on adverse events in a placebo controlled trial of amantadine hydrochloride revealed no group difference, which allowed these events to be reanalyzed descriptively
Amantadine attenuates sepsis-induced cognitive dysfunction possibly not through inhibiting toll-like receptor 2
Xing W, et al.
Journal of Molecular Medicine, 96(5), 391-402 (2018)
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