A0956
异佛手柑内酯
别名:
2-氧代-（2H）-呋喃并（2,3-H）-1-苯并吡喃, 2H-呋喃[2,3-H]-1-苯并吡喃-2-酮, NSC 404563, 异补骨脂素
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关于此项目
经验公式（希尔记法）:
C11H6O3
化学文摘社编号:
分子量:
186.16
UNSPSC Code:
85151701
NACRES:
NA.25
PubChem Substance ID:
MDL number:
Beilstein/REAXYS Number:
153970
Application
异补骨脂素是一种有角的呋喃香豆素，可用作可光活化的分子，与 DNA 和不饱和脂肪酸反应形成单加合物。异补骨脂素可作为潜在的光疗法进行研究，并了解其作用机制和对 RNA 和 DNA 合成的影响。
Biochem/physiol Actions
角呋喃香豆素具有多种光生物效应。在长波紫外线照射下，与双链 DNA 形成单加合物，并与不饱和脂肪酸反应。抑制 Ehrlich 腹水肿瘤细胞中的 DNA 和 RNA 合成，以及细胞复制。
signalword
Warning
hcodes
Hazard Classifications
Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
target_organs
Respiratory system
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges
Md Ataur Rahman et al.
Molecular and cellular biochemistry, 369(1-2), 95-104 (2012-07-07)
Angelicin is structurally related to psoralens, a well-known chemical class of photosensitizers used for its antiproliferative activity in treatment of different skin diseases. To verify the activity of angelicin, we employed human SH-SY5Y neuroblastoma cells to investigate its cytotoxicity, although
Yuan Gu et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 877(27), 3137-3143 (2009-08-13)
A rapid, specific and sensitive ultra-performance liquid chromatography/tandem mass spectrometry (UPLC/MS/MS) method has been established for simultaneous quantitation of psoralen and isopsoralen in rat plasma. Plasma samples were pretreated by direct protein precipitation with acetonitrile. Chromatographic separations were performed on
Liang Feng et al.
Archives of pharmacal research, 33(2), 225-230 (2010-03-03)
Coumarin components from Psoralea corylifolia L. are novel drugs in which psoralen and isopsoralen are the active components. The pharmacokinetics, tissue distribution and excretion of the two compounds were studied by liquid chromatography-tandem mass spectrometry after intravenous administration to Wistar
Paola Barraja et al.
Bioorganic & medicinal chemistry, 18(13), 4830-4843 (2010-07-16)
In the search for new photochemotherapeutic agents, a series of derivatives of the ring system pyrrolo[3,2-h]quinoline--bioisosters of the angular furocoumarin angelicin--were synthesized through a four-step synthetic approach, in reasonable overall yields. Eight of the synthesized derivatives showed a remarkable phototoxicity
Paola Barraja et al.
ChemMedChem, 6(7), 1238-1248 (2011-05-17)
Heteroanalogues of angelicin, pyrrolo[3,2-h]quinazolines, were synthesized with the aim of obtaining new potent photochemotherapeutic agents. Many derivatives caused a significant decrease in cell proliferation in several human tumor cell lines after irradiation with UVA light (GI(50) =15.2-0.2 μM). Their phototoxicity
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DNA damage and repair mechanism is vital for maintaining DNA integrity. Damage to cellular DNA is involved in mutagenesis, the development of cancer among others.
DNA损伤和修复机制对于维持DNA完整性至关重要。细胞DNA的损伤与突变、癌症发展等有关。
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