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About This Item
经验公式（希尔记法）:
C11H6O3
CAS号:
分子量:
186.16
Beilstein:
153970
MDL编号:
UNSPSC代码:
85151701
PubChem化学物质编号:
NACRES:
NA.25
形式
powder
质量水平
储存温度
2-8°C
SMILES字符串
O=C1Oc2c(C=C1)ccc3occc23
InChI
1S/C11H6O3/c12-10-4-2-7-1-3-9-8(5-6-13-9)11(7)14-10/h1-6H
InChI key
XDROKJSWHURZGO-UHFFFAOYSA-N
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应用
异补骨脂素是一种有角的呋喃香豆素，可用作可光活化的分子，与 DNA 和不饱和脂肪酸反应形成单加合物。异补骨脂素可作为潜在的光疗法进行研究，并了解其作用机制和对 RNA 和 DNA 合成的影响。
生化/生理作用
角呋喃香豆素具有多种光生物效应。在长波紫外线照射下，与双链 DNA 形成单加合物，并与不饱和脂肪酸反应。抑制 Ehrlich 腹水肿瘤细胞中的 DNA 和 RNA 合成，以及细胞复制。
警示用语：
Warning
危险分类
Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
靶器官
Respiratory system
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges
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The oxidative dearomatization of 3-(3-alkynyl-4-hydroxyphenyl)propanoic acid is combined with a cascade transition-metal catalyzed cyclization/addition/aromatization/lactamization sequence, which provides a novel approach to prepare furoquinolinone and angelicin derivatives in a convergent and efficient manner.
Li-Qun Ouyang et al.
Analytica chimica acta, 650(2), 160-166 (2009-09-02)
A method using high performance liquid chromatography with photodiode-array detection (HPLC-DAD) coupled with alternating trilinear decomposition (ATLD) algorithm was proposed for simultaneous determination of psoralen and isopsoralen in plasma and Chinese medicine "Xian Ling Gu Bao" capsule (XLGBC). In this
Giampietro Viola et al.
Annals of the New York Academy of Sciences, 1171, 334-344 (2009-09-03)
In this review we summarize the structure and biological effects of linear and angular psoralens. These compounds exhibit interesting biological effects on the cell cycle, apoptosis and differentiation. These molecules should be considered promising drugs in the therapy of several
Paola Barraja et al.
Bioorganic & medicinal chemistry, 18(13), 4830-4843 (2010-07-16)
In the search for new photochemotherapeutic agents, a series of derivatives of the ring system pyrrolo[3,2-h]quinoline--bioisosters of the angular furocoumarin angelicin--were synthesized through a four-step synthetic approach, in reasonable overall yields. Eight of the synthesized derivatives showed a remarkable phototoxicity
Liang Feng et al.
Archives of pharmacal research, 33(2), 225-230 (2010-03-03)
Coumarin components from Psoralea corylifolia L. are novel drugs in which psoralen and isopsoralen are the active components. The pharmacokinetics, tissue distribution and excretion of the two compounds were studied by liquid chromatography-tandem mass spectrometry after intravenous administration to Wistar
商品
DNA damage and repair mechanism is vital for maintaining DNA integrity. Damage to cellular DNA is involved in mutagenesis, the development of cancer among others.
DNA损伤和修复机制对于维持DNA完整性至关重要。细胞DNA的损伤与突变、癌症发展等有关。
我们的科学家团队拥有各种研究领域经验，包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.
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