product name
N-乙酰基-L-脯氨酸,
检测方案
≥98% (TLC)
质量水平
形式
powder
技术
ligand binding assay: suitable
颜色
white
储存温度
2-8°C
SMILES字符串
CC(=O)N1CCC[C@H]1C(O)=O
InChI
1S/C7H11NO3/c1-5(9)8-4-2-3-6(8)7(10)11/h6H,2-4H2,1H3,(H,10,11)/t6-/m0/s1
InChI key
GNMSLDIYJOSUSW-LURJTMIESA-N
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生化/生理作用
N-乙酰基-L-脯氨酸是血管紧张素转化酶（ACE）优选底物的一种COOH-末端二肽部分类似物。它可用于研究底物和抑制剂通过ACE的结合，并区分出各种氨基酰基酶的特异性。
N-乙酰基-L-脯氨酸，一种血管紧张素转化酶优选底物COOH-末端二肽部分的类似物，可用于探测血管紧张素转化酶的活性位点。N-乙酰基-L-脯氨酸可用于鉴定、区分和表征N-酰基-氨基酸酰胺水解酶/氨基酰化酶。N-乙酰基-L-脯氨酸可用于研究脯氨酸的理化参数。
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, type N95 (US)
J Krapcho et al.
Journal of medicinal chemistry, 31(6), 1148-1160 (1988-06-01)
Analogues of captopril, enalaprilat, and the phosphinic acid [hydroxy(4-phenylbutyl)phosphinyl]acetyl]-L-proline incorporating 4-substituted proline derivatives have been synthesized and evaluated as inhibitors of angiotensin-converting enzyme (ACE) in vitro and in vivo. The 4-substituted prolines, incorporating alkyl, aryl, alkoxy, aryloxy, alkylthio, and arylthio
Mayuko Koreishi et al.
Bioscience, biotechnology, and biochemistry, 69(10), 1914-1922 (2005-10-26)
A novel aminoacylase was purified to homogeneity from culture broth of Streptomyces mobaraensis, as evidenced by SDS-polyacrylamide gel electrophoresis (PAGE). The enzyme was a monomer with an approximate molecular mass of 100 kDa. The purified enzyme was inhibited by the
Abil E Aliev et al.
The journal of physical chemistry. B, 111(50), 14034-14042 (2007-11-22)
The results of the ring conformational analysis of L-proline, N-acetyl-L-proline, and trans-4-hydroxy-L-proline by NMR combined with calculations using density functional theory (DFT) and molecular dynamics (MD) are reported. Accurate values of 1H-1H J-couplings in water and other solvents have been
Kyung-Koo Lee et al.
The journal of physical chemistry. B, 110(38), 18834-18843 (2006-09-22)
A few experimental and theoretical studies on the molecular structure of N-acetylproline amide (AP) in D2O solution have been reported recently. However, there is no consensus of the precise structure of AP in D2O because spectroscopically determined structures and a
R A Pfuetzner et al.
The Journal of biological chemistry, 263(9), 4056-4058 (1988-03-25)
We have investigated the interaction of ligands in the active site of the angiotensin-converting enzyme from rabbit lung by monitoring the concurrent effects of two inhibitors on enzyme activity. A strong synergism is found in the binding of N-acetyl-L-proline (an
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