一般描述
L -氮杂环丁烷-2-羧酸是一种非蛋白氨基酸和致畸剂。它是有毒的。
应用
L -氮杂环丁烷-2-羧酸已被用作液相色谱-质谱法中的标准品:
- 胶原合成抑制剂
- 蛋白折叠拮抗剂
生化/生理作用
L-氮杂环丁烷-2-羧酸是胶原合成抑制剂,具有抗血管生成作用。它是 L-脯氨酸的四元环类似物,当掺入它而不是脯氨酸时导致蛋白质错构。
在干扰新生蛋白折叠时,氮杂环丁烷-2-羧酸 (AZC) 触发蛋白聚集或上调易于聚集的突变蛋白的表达。
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, type N95 (US)
Ascorbic acid promotes the stemness of corneal epithelial stem/progenitor cells and accelerates epithelial wound healing in the cornea
Stem Cells Translational Medicine, 6(5), 1356-1365 (2017)
The anticancer drug AUY922 generates a proteomics fingerprint that is highly conserved among structurally diverse Hsp90 inhibitors
Journal of Proteome Research, 12(8), 3697-3706 (2013)
Molecular biology of the cell, 21(13), 2102-2116 (2010-05-14)
Quality control systems facilitate polypeptide folding and degradation to maintain protein homeostasis. Molecular chaperones promote folding, whereas the ubiquitin/proteasome system mediates degradation. We show here that Saccharomyces cerevisiae Ubr1 and Ubr2 ubiquitin ligases promote degradation of unfolded or misfolded cytosolic
Essential function of Mec1, the budding yeast ATM/ATR checkpoint-response kinase, in protein homeostasis
Developmental Cell, 46(4), 495-503 (2018)
Azetidine-2-carboxylic acid in garden beets (Beta vulgaris)
Phytochemistry, 67(9), 898-903 (2006)
我们的科学家团队拥有各种研究领域经验,包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.
联系技术服务部门