所有图片(3)
About This Item
经验公式（希尔记法）:
C15H23N5O14P2
CAS号:
分子量:
559.32
MDL编号:
UNSPSC代码:
41106305
PubChem化学物质编号:
NACRES:
NA.51
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![1,8-二氮杂双环[5.4.0]十一碳-7-烯 98%](/deepweb/assets/sigmaaldrich/product/structures/120/564/5b373e23-1624-489c-8efb-692de0f96ffb/640/5b373e23-1624-489c-8efb-692de0f96ffb.png)
生物来源
yeast (candida utilis)
质量水平
方案
≥93%
表单
powder
储存温度
−20°C
SMILES字符串
[Na].Nc1ncnc2n(cnc12)C3OC(COP(O)(=O)OP(O)(=O)OCC(O)C(O)C(O)C=O)C(O)C3O
InChI
1S/C15H23N5O14P2.Na.H/c16-13-9-14(18-4-17-13)20(5-19-9)15-12(26)11(25)8(33-15)3-32-36(29,30)34-35(27,28)31-2-7(23)10(24)6(22)1-21;;/h1,4-8,10-12,15,22-26H,2-3H2,(H,27,28)(H,29,30)(H2,16,17,18);;
InChI key
NWPVXDZLQTURKI-UHFFFAOYSA-N
应用
使用5′-脱氧-5′-(甲硫基)腺苷：
- 给出一系列烟酰胺腺嘌呤二核苷酸(NADH)
- 氧化速率，用于呼吸链复合体(CI/CIII/CIV)
- CI/替代(AOX) 通路
- 测定聚腺苷二磷酸核糖甘油水解酶活性
- 聚腺苷二磷酸核糖(PAR)结合竞争性分析
- 氧化酶(AOX)通路
- 测定聚腺苷二磷酸核糖甘油水解酶活性
- 聚腺苷二磷酸核糖(PAR)结合竞争性分析
生化/生理作用
通过聚腺苷二磷酸核糖聚合酶(PARP)家族成员形成聚腺苷二磷酸核糖(ADP-ribose)时，腺苷5′-二磷酸核糖(ADP-Ribose)用作底物的基础嵌段。聚腺苷酸核糖的形成和降解是脱氧核糖核酸修复和凋亡信号的重要组成部分。ADP-核糖启动瞬时受体电位亚家族褪黑素 2 型 (TRPM2)，即 Na+、Ca2+和K+阳离子通道。
警示用语：
Warning
危险声明
危险分类
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
靶器官
Respiratory system
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
dust mask type N95 (US), Eyeshields, Gloves
法规信息
监管及禁止进口产品
历史批次信息供参考:
分析证书(COA)
Lot/Batch Number
Mitochondrial supercomplexes do not enhance catalysis by quinone channeling
Fedor, Justin G and Hirst, Judy
Cell Metabolism, 28(3), 525-531 (2018)
Shai White-Gilbertson et al.
Journal of lipid research, 60(7), 1225-1235 (2019-04-17)
Radiation treatment failure or relapse after initial response to chemotherapy presents significant clinical challenges in cancer patients. Escape from initial courses of treatment can involve reactivation of embryonic developmental stages, with the formation of polynuclear giant cancer cells (PGCCs). This
Marcos Roberto de Oliveira et al.
Journal of molecular neuroscience : MN, 69(1), 115-122 (2019-05-28)
Redox impairment, inflammation, and increased rates of cell death are central players during neurodegeneration. In that context, activation of the transcription factor nuclear factor erythroid 2-related factor 2 (Nrf2) has been viewed as an interesting strategy in order to reduce
Byung Kil Park et al.
International journal of radiation biology, 95(8), 1094-1102 (2019-03-05)
Purpose: The present study aimed to investigate the potential protective effects of icariin both in vivo and in vitro, an active flavonoid glucoside derived from medicinal herb Epimedium, and its possible mechanisms against radiation-induced injury. Methods: Male C57BL/6 mice were
Chun-Yu Liu et al.
Molecular oncology, 11(3), 266-279 (2017-01-14)
Recurrent triple-negative breast cancer (TNBC) needs new therapeutic targets. Src homology region 2 domain-containing phosphatase-1 (SHP-1) can act as a tumor suppressor by dephosphorylating oncogenic kinases. One major target of SHP-1 is STAT3, which is highly activated in TNBC. In
商品
LC-MS/MS method quantifies similar polar nucleotide activated sugars using Supel™ Carbon LC column for simultaneous analysis.
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