生物来源
human plasma
质量水平
检测方案
≥85% (SDS-PAGE)
形式
buffered aqueous solution
分子量
28.3 kDa
技术
ELISA: suitable
UniProt登记号
运输
dry ice
储存温度
−20°C
基因信息
human ... APOA1(335)
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应用
人血浆来源载脂蛋白A-1用于诱导硝基苯并恶二唑（NBD）-胆固醇负载细胞中的胆固醇外流。也用于通过酶联免疫吸附测定（ELISA）检测IgG抗apoA-1抗体。
高密度脂蛋白 (HDL) 中的主要蛋白质成分
生化/生理作用
Apo-AI 约占 HDL 蛋白部分的 70%，是由 245 个氨基酸组成的单一多肽链，其中C 端残基为谷氨酸，N 端残基为天冬氨酸。据报道，分子量为 28.3 kDa。该蛋白由 1 个主要同种型 (pI 5.6) 和 2 个次要同种型（pI 5.53 和 5.46）组成。Apo-AI 显示高含量 α -螺旋结构。α-螺旋结构中的两亲性区域似乎负责脂质结合能力。在水溶液中，Apo-AI 发生自缔合，构象变化较小。Apo-AI 可激活卵磷脂-胆固醇 (LCAT) 酰基转移酶，该酶负责血浆中的胆固醇酯化。
正常血浆 Apo-AI 水平为 90-130 mg/dL。Apo-AI 水平可能与冠状动脉疾病的风险呈负相关。
正常血浆 Apo-AI 水平为 90-130 mg/dL。Apo-AI 水平可能与冠状动脉疾病的风险呈负相关。
外形
10 mM 碳酸氢铵溶液
免责声明
仅供研究使用。在法国，在用于科研目的时（包括进口和出口活动（《公共健康法》第L 1211-1条，第2节））该产品为管制品。购买者（即最终用户）需要获得《公共健康法》法第L 1211-1条规定的法国研究部的进口授权。订购本产品即表明您确认已经获得合适的进口授权。
储存分类代码
10 - Combustible liquids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
常规特殊物品
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商品
由于胆固醇是水不溶性分子，必须包装后才能在血浆中运输。包装胆固醇、胆固醇酯和甘油三酯以便运输的颗粒称为脂蛋白。
Lipoproteins package cholesterol for transport in plasma, essential for lipid transport and cellular function in the body.
Lipoproteins package cholesterol for transport in plasma, essential for lipid transport and cellular function in the body.
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