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Merck
CN

A0606

Sigma-Aldrich

金硫代葡萄糖 水合物

≥96% (titration)

别名:

Solganal, Solganol, 金硫代葡萄糖

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About This Item

经验公式(希尔记法):
C6H11AuO5S · xH2O
CAS号:
分子量:
392.18 (anhydrous basis)
EC 号:
UNSPSC代码:
12352200
PubChem化学物质编号:
NACRES:
NA.77

质量水平

方案

≥96% (titration)

表单

powder

储存条件

desiccated

颜色

white to beige

溶解性

H2O: 5 mg/mL, clear

储存温度

2-8°C

SMILES字符串

O.OC[C@H]1O[C@H](S[Au])[C@H](O)[C@@H](O)[C@@H]1O

InChI

1S/C6H12O5S.Au.H2O/c7-1-2-3(8)4(9)5(10)6(12)11-2;;/h2-10,12H,1H2;;1H2/q;+1;/p-1/t2-,3-,4+,5-,6-;;/m1../s1

InChI key

SGVIEHTYEMEDRR-PKXGBZFFSA-M

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应用

硫代葡萄糖水合物已用于人细胞系中的氧化还原应激存活测定,并用于诱导小鼠肥胖表型。

生化/生理作用

强效PKCι-Par6交互效应抑制剂
最近发现,临床上用于治疗类风湿关节炎的金化合物金硫代葡萄糖是一种有效的PKCiota-Par6交互效应抑制剂,IC50约为1 μM。破坏该交互效应会破坏rac1信号通路,这是非小细胞肺癌转化生长所必需的。

特点和优势

该化合物是受体分类及信号转导手册上PKC页面上的特色化合物。想要浏览手册的其他页面, 请单击此处

象形图

Health hazard

警示用语:

Danger

危险声明

危险分类

Resp. Sens. 1 - Skin Sens. 1

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

dust mask type N95 (US), Eyeshields, Faceshields, Gloves


历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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Cancer research, 66(3), 1767-1774 (2006-02-03)
We recently showed that atypical protein kinase Ciota (PKCiota) is required for transformed growth of human non-small-cell lung cancer (NSCLC) cells by activating Rac1. Genetic disruption of PKCiota signaling blocks Rac1 activity and transformed growth, indicating that PKCiota is a
K D Anderson et al.
Journal of neuroendocrinology, 15(7), 649-660 (2003-06-06)
Similar to leptin, ciliary neurotrophic factor (CNTF) suppresses appetite and selectively reduces body fat in leptin-deficient ob/ob mice. To assess the relative importance of specific regions of the hypothalamus in mediating these effects, we administered a CNTF analogue (CNTFAx15) or
KH176 Safeguards Mitochondrial Diseased Cells from Redox Stress-Induced Cell Death by Interacting with the Thioredoxin System/Peroxiredoxin Enzyme Machinery.
Beyrath J, et al.
Scientific Reports, 8 (2018)
Satoru Sakuma et al.
Life sciences, 75(10), 1211-1218 (2004-06-29)
Effects of auranofin (AUR), aurothioglucose (AuTG) and aurothiomalate (AuTM) on the conversion of xanthine dehydrogenase (XD) to oxidase (XO) in the cytosolic fraction from rabbit liver were examined. AUR had no effect on the conversion of XD to XO at
M D Levin et al.
The Netherlands journal of medicine, 61(6), 223-225 (2003-09-19)
Thrombocytopenia is a well-known side effect following intramuscular gold therapy in patients with rheumatoid arthritis. Thrombocytopenia may occur at any time and it can be irreversible and sometimes fatal despite cytotoxic or immunosuppressive therapy. We describe two patients who presented

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