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Merck
CN

A0606

金硫代葡萄糖 水合物

≥96% (titration), PKCι-Par6 interaction inhibitor, powder

别名:

Solganal, Solganol, 金硫代葡萄糖

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关于此项目

经验公式(希尔记法):
C6H11AuO5S · xH2O
化学文摘社编号:
分子量:
392.18 (anhydrous basis)
UNSPSC Code:
12352200
PubChem Substance ID:
NACRES:
NA.77
EC Number:
235-365-7
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产品名称

金硫代葡萄糖 水合物, ≥96% (titration)

InChI

1S/C6H12O5S.Au.H2O/c7-1-2-3(8)4(9)5(10)6(12)11-2;;/h2-10,12H,1H2;;1H2/q;+1;/p-1/t2-,3-,4+,5-,6-;;/m1../s1

InChI key

SGVIEHTYEMEDRR-PKXGBZFFSA-M

SMILES string

O.OC[C@H]1O[C@H](S[Au])[C@H](O)[C@@H](O)[C@@H]1O

assay

≥96% (titration)

form

powder

storage condition

desiccated

color

white to beige

solubility

H2O: 5 mg/mL, clear

storage temp.

2-8°C

Quality Level

Application

硫代葡萄糖水合物已用于人细胞系中的氧化还原应激存活测定,并用于诱导小鼠肥胖表型。

Biochem/physiol Actions

强效PKCι-Par6交互效应抑制剂
最近发现,临床上用于治疗类风湿关节炎的金化合物金硫代葡萄糖是一种有效的PKCiota-Par6交互效应抑制剂,IC50约为1 μM。破坏该交互效应会破坏rac1信号通路,这是非小细胞肺癌转化生长所必需的。

Features and Benefits

该化合物是受体分类及信号转导手册上PKC页面上的特色化合物。想要浏览手册的其他页面, 请单击此处

pictograms

Health hazard

signalword

Danger

hcodes

Hazard Classifications

Resp. Sens. 1 - Skin Sens. 1

存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Faceshields, Gloves


历史批次信息供参考:

分析证书(COA)

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Kouichi Yoshinari et al.
Pharmaceutical research, 23(6), 1188-1200 (2006-05-23)
Changes in physiological, pathophysiological, and/or nutritional conditions often alter the expression of drug-metabolizing enzymes. In this study, we investigated obesity-induced changes in hepatic cytochrome P450 (P450) levels using nutritionally obese mice. To induce obesity, mice were fed a high-fat diet
Mitsunari Ogasawara et al.
Liver international : official journal of the International Association for the Study of the Liver, 31(4), 542-551 (2011-03-09)
The search for effective treatments of non-alcoholic steatohepatitis (NASH), now the most common chronic liver disease in affluent countries, is hindered by a lack of animal models having the range of anthropometric and pathophysiological features as human NASH. To examine
Eric N van Roon et al.
The Journal of rheumatology, 32(6), 1026-1030 (2005-06-09)
For reasons of insufficient quality of the raw material, aurothioglucose was withdrawn from the Dutch market at the end of 2001. Aurothiomalate became available as an alternative preparation. We followed a cohort of patients during the first year after switching
Melody Stallings-Mann et al.
Cancer research, 66(3), 1767-1774 (2006-02-03)
We recently showed that atypical protein kinase Ciota (PKCiota) is required for transformed growth of human non-small-cell lung cancer (NSCLC) cells by activating Rac1. Genetic disruption of PKCiota signaling blocks Rac1 activity and transformed growth, indicating that PKCiota is a
K D Anderson et al.
Journal of neuroendocrinology, 15(7), 649-660 (2003-06-06)
Similar to leptin, ciliary neurotrophic factor (CNTF) suppresses appetite and selectively reduces body fat in leptin-deficient ob/ob mice. To assess the relative importance of specific regions of the hypothalamus in mediating these effects, we administered a CNTF analogue (CNTFAx15) or

商品

Protein kinase C (PKC) is an AGC kinase that phosphorylates serine and threonine residues in many target proteins.

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