质量水平
检测方案
≥98% (HPLC)
形式
powder
储存条件
desiccated
颜色
white to off-white
溶解性
DMSO: ≥20 mg/mL
创始人
Baxter
储存温度
2-8°C
InChI
1S/C23H36N6O5S.H2O/c1-14-8-10-29(18(12-14)22(31)32)21(30)17(6-4-9-26-23(24)25)28-35(33,34)19-7-3-5-16-11-15(2)13-27-20(16)19;/h3,5,7,14-15,17-18,27-28H,4,6,8-13H2,1-2H3,(H,31,32)(H4,24,25,26);1H2/t14-,15?,17?,18-;/m1./s1
InChI key
AIEZTKLTLCMZIA-LINCPPCXSA-N
正在寻找类似产品? 访问 产品对比指南
一般描述
阿加曲班抗凝剂由L-精氨酸合成，在光照下会发生光降解。
应用
阿加曲班一水合物已被用作贫血小板血浆样品凝血酶测定中的凝血酶选择性抑制剂。它可用作标准品，用于梯度反相液相色谱-高分辨率多级质谱联用法 (LC/HR-MSn) 光产物片段化分析，另外还可用于富勒烯C60纳米颗粒（NP）的凝血酶抑制剂竞争性测定。
生化/生理作用
阿加曲班具有高亲和力，并与凝血酶活性位点中的精氨酸结合，从而导致阻碍底物结合的空间位阻。阿加曲班可有效预防血栓形成，并且比普通肝素更有利于溶栓。建议用于急性缺血性中风的治疗。
阿加曲班是一种强效、选择性、单价凝血酶直接抑制剂。与既结合活性站点又结合外部位点 1 的二价 DTI（水蛭素及其类似物）相比，它只结合凝血酶的活性点位（因此属于单价）而直接抑制凝血酶。
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
Arnat Balabiyev et al.
Biomaterials, 277, 121087-121087 (2021-09-04)
Implantation of biomaterials and medical devices in the body triggers the foreign body reaction (FBR) which is characterized by macrophage fusion at the implant surface leading to the formation of foreign body giant cells and the development of the fibrous
Solution-Mediated Phase Transformation of Argatroban: Ternary Phase Diagram, Rate-Determining Step, and Transformation Kinetics
Wang Y, et al.
Industrial & Engineering Chemistry Research, 56(15), 4539-4548 (2017)
Photodegradation of aqueous argatroban investigated by LC/MSn: Photoproducts, transformation processes and potential implications
Secretan PH, et al.
Journal of Pharmaceutical and Biomedical Analysis, 131(29387), 223-232 (2016)
Jeremy B Chang et al.
Scientific reports, 6, 29387-29387 (2016-07-22)
A central challenge in designing and administering effective anticoagulants is achieving the proper therapeutic window and dosage for each patient. The Hill coefficient, nH, which measures the steepness of a dose-response relationship, may be a useful gauge of this therapeutic
Effects of argatroban and heparin on thrombus formation and tissue plasminogen activator-induced thrombolysis in a microvascular thrombosis model
Yamada K, et al.
Thrombosis Research, 109(1), 55-64 (2003)
商品
Bioactive small molecules for immune system signaling target identification/validation and antibiotics, antivirals, and antifungals offered.
我们的科学家团队拥有各种研究领域经验，包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.
联系技术服务部门